ChemicalBook > CAS DataBase List > Ethyl (3-chlorobenzoyl)acetate

Ethyl (3-chlorobenzoyl)acetate

Product Name
Ethyl (3-chlorobenzoyl)acetate
CAS No.
33167-21-4
Chemical Name
Ethyl (3-chlorobenzoyl)acetate
Synonyms
ETHYL (3-CHLOROBENZOYL)ACETATE;Ethyl 2-(3-chlorobenzoyl)acetate;Ethyl (3-chlorobenzoyl)acetate >=97%;Ethyl 3-chloro-β-oxobenzenepropanoate;2-[(3-chlorophenyl)-oxomethyl]butanoate;Ethyl (3-chlorobenzoyl)acetate;ETHYL 3-(3-CHLOROPHENYL)-3-OXOPROPANOATE;3-Chloro--oxobenzenepropanoic acid ethyl ester;3-(3-chlorophenyl)-3-oxopropanoic acid ethyl ester;Benzenepropanoic acid, 3-chloro-β-oxo-, ethyl ester
CBNumber
CB1359370
Molecular Formula
C11H11ClO3
Formula Weight
226.66
MOL File
33167-21-4.mol
More
Less

Ethyl (3-chlorobenzoyl)acetate Property

Boiling point:
257-258 °C (lit.)
Density 
1.213 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.5460(lit.)
Flash point:
>230 °F
storage temp. 
Sealed in dry,Room Temperature
pka
9.91±0.46(Predicted)
CAS DataBase Reference
33167-21-4(CAS DataBase Reference)
More
Less

Safety

WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
559288
Product name
Ethyl (3-chlorobenzoyl)acetate
Purity
≥97%
Packaging
1g
Price
$140
Updated
2023/06/20
Sigma-Aldrich
Product number
559288
Product name
Ethyl (3-chlorobenzoyl)acetate
Purity
≥97%
Packaging
5g
Price
$513
Updated
2023/06/20
TRC
Product number
E678620
Product name
Ethyl (3-chlorobenzoyl)acetate
Packaging
1g
Price
$100
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0011839
Product name
3-(3-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
Purity
95.00%
Packaging
1G
Price
$239.4
Updated
2021/12/16
AK Scientific
Product number
3801AB
Product name
Ethyl (3-chlorobenzoyl)acetate
Packaging
5g
Price
$195
Updated
2021/12/16
More
Less

Ethyl (3-chlorobenzoyl)acetate Chemical Properties,Usage,Production

Uses

Reagent / reactant involved in:• ;Oxidative cross-coupling via dioxygen activation with indoles1• ;Chlorination and hydrosilylation for synthesis of α-hydroxy β-amino acid derivatives2• ;Precursor for substrates for chiral Lewis base-catalyzed stereoselective reduction with trichlorosilane and water3• ;Intramolecular cyclization for synthesis of dihydrofurans4• ;Rate acceleration of Michael reactions5• ;Cerium ammonium nitrate-mediated oxidative coupling6

Uses

Reagent / reactant involved in:

  • Oxidative cross-coupling via dioxygen activation with indoles
  • Chlorination and hydrosilylation for synthesis of α-hydroxy β-amino acid derivatives
  • Precursor for substrates for chiral Lewis base-catalyzed stereoselective reduction with trichlorosilane and water
  • Intramolecular cyclization for synthesis of dihydrofurans
  • Rate acceleration of Michael reactions
  • Cerium ammonium nitrate-mediated oxidative coupling

Synthesis

141.6 g of diethyl carbonate was dissolved in 1000 mL of a 1:1 ethanol-tetrahydrofuran (THF) solution, and 12.4 g of catalyst 1 Amberlite IRA-400 was added while stirring. The mixture was then heated up to 45 °C. In a separate container, 154.5 g of m-chloroacetophenone was dissolved in 1000 mL of the above-mentioned ethanol-THF mixed solvent. The addition of m-chloroacetophenone was completed within 1 hour, and stirring was continued for 6 hours. The mixture was then filtered. The filtrate was combined and the majority of the solvent was evaporated. 1500 mL of water was added to the remaining solution while stirring. The solution was then subjected to CH2Cl2 extraction, followed by washing with saturated saline until the solution reached a neutral pH. The resulting solution was dried with anhydrous MgSO4, filtered, and the solvent was evaporated. Finally, the resulting residue was distilled under reduced pressure to obtain a colorless oily liquid known as Ethyl (3-chlorobenzoyl)acetate.

Ethyl (3-chlorobenzoyl)acetate Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Ethyl (3-chlorobenzoyl)acetate Suppliers

Canada 1 China 68 Germany 2 India 2 Switzerland 1 Ukraine 1 United Kingdom 3 United States 13 Global 91
ZhengZhou Edward Biology Co.,Ltd
Tel
13298105281 13298105281
Email
1522334715@qq.com
Country
China
ProdList
7507
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
18017383231 18017383231
Fax
qq：2817624287
Email
lyh_antaeus@163.com
Country
China
ProdList
9347
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828 4008675858
Fax
+86-512-56316826
Email
sales@amateksci.com
Country
China
ProdList
9894
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 18112977050
Email
cb6@aikonchem.com
Country
China
ProdList
16684
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Shanghai Synchem Pharma Co., ltd
Tel
21-619849051-1 18521059765
Email
synchempharma@aliyun.com
Country
China
ProdList
6463
Advantage
55
TaiChem Taizhou Limited
Tel
052386810091
Email
zcwy9518@yeah.net
Country
China
ProdList
3899
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27313
Advantage
60
Shanghai SuperLan Chemcial Technique Centre
Tel
021-2022843681 15618226720
Fax
+86-21-51601218
Email
lucy@atkchemical.com
Country
China
ProdList
9952
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Nanjing KaiMubo Pharmaceutical Co., Ltd.
Tel
025-66162170
Fax
025-66162170
Country
China
ProdList
7181
Advantage
55
Yantai ShengKailun Chemical Technology Co., Ltd.
Tel
13356901049
Fax
QQ：1025383091
Email
3119594100@qq.com
Country
China
ProdList
7964
Advantage
55
Biokitchen
Tel
021-021-021-31663258 13795219287
Fax
021-31663258
Email
donghuanwen@126.com
Country
China
ProdList
1928
Advantage
58
Rhawn Reagent
Tel
400-400-1332688 18019345275
Fax
400-133-2688
Email
amy@rhawn.cn
Country
China
ProdList
15497
Advantage
58
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400-6387771-6037 18920794737
Email
sales@heowns.com
Country
China
ProdList
22961
Advantage
60
Cool Pharm, Ltd
Tel
18019463053
Fax
021-50966098
Email
sales@coolpharm.com
Country
China
ProdList
13010
Advantage
58
Nanjing Asfam Pharmaceutical Technology Co., Ltd.
Tel
025-58867862 18751812725
Fax
02558867862
Email
sales@ace-pharm.com
Country
China
ProdList
2000
Advantage
58
Shanghai Gugang New Materials Technology Co. Ltd.
Tel
021-51317962
Fax
021-51317962
Email
296935822@qq.com
Country
China
ProdList
978
Advantage
58
Suzhou Rovathin Foreign Trade Co.,Ltd
Tel
0512-65816829 18662214788
Fax
0512-65816829
Email
info@rovathin.com.cn
Country
China
ProdList
9655
Advantage
58
Anhui Yongsheng Pharmaceutical Technology Co., Ltd.
Tel
021-50430803 18016036736
Fax
qq：1278656443
Email
lyh_antaeus@163.com
Country
China
ProdList
760
Advantage
58
ANHUI WITOP BIOTECH CO., LTD
Tel
+8615255079626
Email
eric@witopchemical.com
Country
China
ProdList
23541
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418671 +8618949823763
Fax
0551-65418697
Email
sales@tnjchem.com
Country
China
ProdList
34563
Advantage
58
Shanghai Minhan Pharmaceutical Technology Co., Ltd.
Tel
176121882
Fax
QQ 2816925681
Email
2816925681@qq.com
Country
China
ProdList
2721
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49374
Advantage
58
Shanghai Kaiwei Chemical Technology Co., Ltd.
Tel
021-58461859 15821823057
Email
service@aiviche.com
Country
China
ProdList
49312
Advantage
58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
Tel
+8613580539051
Email
joe@yuhengpharm.com
Country
CHINA
ProdList
21142
Advantage
58
Zhengzhou Convergence Chemical Co. LTD
Tel
0371-53736046 13393710386
Fax
QQ:2853979814
Email
2853979814@qq.com
Country
China
ProdList
9996
Advantage
58
Lingyuan Bebiansen Biological Technology Co., Ltd
Tel
18642120371
Email
2837458851@qq.com
Country
China
ProdList
7995
Advantage
58
Nanjing Puxin Pharmaceutical Technology Co., Ltd
Tel
17366295326
Fax
QQ360829978
Email
puxinpharma_2017@126.com
Country
China
ProdList
2444
Advantage
58
Yantai Boyun Biological Technology Co. Ltd
Tel
13793517650; 13793517650
Email
2767277144@qq.com
Country
China
ProdList
2888
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
39995
Advantage
58
Hefei Mokai Pharmaceutical Technology Co., Ltd
Tel
18130062233
Email
3362556465@qq.com
Country
China
ProdList
8000
Advantage
58
Bide Pharmatech Ltd.
Tel
400-6005915
Email
sales@picasso-e.com
Country
China
ProdList
39665
Advantage
58
Changzhou Bojia Biomedical Technology Co., Ltd.
Tel
2122619822
Email
czbjpharma@126.com
Country
China
ProdList
18478
Advantage
58
Yantai Zhengxin New Material Technology Co. LTD
Tel
15065715832; 13854547682
Email
542660804@qq.com
Country
China
ProdList
3724
Advantage
58
Aikon International Limited
Tel
18626450290
Email
yftan@aikonchem.com
Country
China
ProdList
10715
Advantage
58
Shanghai klamar Reagent Co., LTD
Tel
4001650900 13817534909
Email
3003940895@qq.com
Country
China
ProdList
10717
Advantage
58
Zhengzhou Hong Sheng Pharmaceutical Technology Co. Ltd.
Tel
0371-55695890 15637198702
Email
1677336983@qq.com
Country
China
ProdList
13191
Advantage
58
Yantai Sheng Kai Lun Biological Products Co. , Ltd.
Tel
13356901049
Email
mark@sklnchem.cn
Country
China
ProdList
14384
Advantage
58
Envchem Bioscience (Shanghai) Co., Ltd.
Tel
13012862996
Email
xuzhao0905@163.com
Country
China
ProdList
280
Advantage
58
Anhui Yongsheng Pharmaceutical Technology Co., Ltd
Tel
18017383231
Email
1849315414@qq.com
Country
China
ProdList
833
Advantage
58
Shanghai Jianchao Biotechnology Co., LTD
Tel
13621743886 13621743886
Email
3366408901@qq.com
Country
China
ProdList
4563
Advantage
58
Shandong Jiuyue Biological Technology Co. LT
Tel
18853316981 18853316981
Email
1214127295@qq.com
Country
China
ProdList
2769
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 17801761073
Email
Gsiyu@solarbio.com
Country
China
ProdList
50464
Advantage
58
Zhuhai Aobokai Biomedical Technology Co., Ltd.
Tel
400-0628126 15697565236;
Email
sales-team@aobchem.com.cn
Country
China
ProdList
50192
Advantage
58

33167-21-4, Ethyl (3-chlorobenzoyl)acetateRelated Search:

Ethyl (3-chlorobenzoyl)acetate 3-(4-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER,ETHYL 3-(4-CHLOROPHENYL)-3-OXOPROPANOATE ethyl 3-(2,5-dichlorophenyl)-3-oxopropanoate 2,4,5-TRICHLORO-BETA-OXO-BENZENEPROPANOIC ACID ETHYL ESTER 7,8-DICHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 3-(3,4-DICHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Ethyl 3-(3,5-dichlorophenyl)-3-oxopropanoate ETHYL 3-OXO-3-(2,3,4-TRICHLOROPHENYL)PROPANOATE ETHYL (3-CHLORO-5-FLUOROBENZOYL)ACETATE 3-(2-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER AKOS MSC-0295 AKOS 90068 RARECHEM AL BI 0740 SALOR-INT L136042-1EA RARECHEM AL BI 0440 RARECHEM AL BI 0586 RARECHEM AL BI 0716 3-(3-CHLORO-PHENYL)-2-CYANO-3-OXO-PROPIONIC ACID ETHYL ESTER

  • ETHYL 3-(3-CHLOROPHENYL)-3-OXOPROPANOATE
  • ETHYL (3-CHLOROBENZOYL)ACETATE
  • 3-(3-CHLORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
  • Ethyl 2-(3-chlorobenzoyl)acetate
  • 2-[(3-chlorophenyl)-oxomethyl]butanoate
  • 3-Chloro--oxobenzenepropanoic acid ethyl ester
  • Ethyl (3-chlorobenzoyl)acetate >=97%
  • 3-(3-chlorophenyl)-3-keto-propionic acid ethyl ester
  • 3-(3-chlorophenyl)-3-oxopropanoic acid ethyl ester
  • Benzenepropanoic acid, 3-chloro-β-oxo-, ethyl ester
  • Ethyl (3-<WBR>chlorobenzoyl)<WBR>acetate
  • BENZENEPROPANOIC ACID, 3-CHLORO-Β-OXO-, ETHYL ESTER
  • Ethyl 3-chloro-β-oxobenzenepropanoate
  • 33167-21-4
  • Esters
  • Organic Building Blocks
  • Building Blocks
  • C10 to C11
  • Carbonyl Compounds
  • C10 to C11
  • Carbonyl Compounds
  • Esters
  • Building Blocks
  • C10 to C11
  • Carbonyl Compounds
  • Chemical Synthesis
  • Organic Building Blocks