Cefuroxime sodium
Description References- Product Name
- Cefuroxime sodium
- CAS No.
- 56238-63-2
- Chemical Name
- Cefuroxime sodium
- Synonyms
- zinacef;Cefuroxime sodium CRS;Zinace;Ipacef;Kesint;Duxima;Bioxima;640/359;Cefamar;Cefumax
- CBNumber
- CB1367915
- Molecular Formula
- C16H15N4O8S.Na
- Formula Weight
- 446.37
- MOL File
- 56238-63-2.mol
Cefuroxime sodium Property
- Melting point:
- 240-245°C(dec)
- alpha
- D20 +60° (c = 0.91 in water)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Freely soluble in water, very slightly soluble in ethanol (96 per cent).
- pka
- pKa (water): 2.5; (DMF): 5.1(at 25℃)
- form
- Solid
- color
- White to Pale Beige
- Water Solubility
- Freely soluble in water
- InChIKey
- URDOHUPGIOGTKV-JTBFTWTJSA-M
- CAS DataBase Reference
- 56238-63-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 42/43-36/37/38-20/21/22
- Safety Statements
- 22-36/37-45-36-26
- WGK Germany
- 2
- RTECS
- XI0330000
- HS Code
- 29419000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- C4417
- Product name
- Cefuroxime sodium salt
- Packaging
- 1g
- Price
- $160
- Updated
- 2024/03/01
- Product number
- PHR2683
- Product name
- Cefuroxime Sodium
- Purity
- certified reference material, pharmaceutical secondary standard
- Packaging
- 300MG
- Price
- $173
- Updated
- 2024/03/01
- Product number
- BP925
- Product name
- Cefuroxime sodium
- Purity
- British Pharmacopoeia (BP) Reference Standard
- Packaging
- 150MG
- Price
- $257
- Updated
- 2024/03/01
- Product number
- 1098209
- Product name
- Cefuroxime sodium
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- J66999
- Product name
- Cefuroxime sodium salt, 95%
- Packaging
- 1g
- Price
- $120
- Updated
- 2024/03/01
Cefuroxime sodium Chemical Properties,Usage,Production
Description
Cefuroxime sodium is marketed by Eli Lilly and Company under the trade name of Kefurox® and by Glaxo Limited under the trade name of Zinacef®. Cefuroxime sodium is an off-white to white amorphous powder. Cefuroxime sodium is an injectable second generation, semisynthetic, broad spectrum cephalosporin antibiotic with excellent activity in vitro, enhanced stability to many enterobacterial β-lactamases and favorable pharmacokinetic properties.
It is used to treat a wide variety of bacterial infections. It is effective for treating meningitis, lower respiratory tract infections, urinary tract infections, gonorrhea, septicemia, skin and skin infections, bone and joint infections, and is approved for surgical prophylaxis.
References
[1] Timothy J. Woznaik and John R. Hicks, Analytical Profile of Cefuroxime Sodium, Analytical Profiles of Drug Substances, 1991, vol. 20, 209-236
[2] https://dailymed.nlm.nih.gov
[3] L. M. Galanti, J. D. Hecq, D. Vanbeckbergen and J. Jamart, Long-term stability of cefuroxime and cefazolin sodium in intravenous infusions, Journal of Clinical Pharmacy and Therapeutics, 1996, vol. 21, 185-189
Chemical Properties
White Crystalline Solid
Originator
Ultroxim,Duncan,Italy,1978
Uses
Cephalosporin antibacterial.
Uses
Cefuroxime Sodium Salt is an antibacterial.
Definition
ChEBI: Cefuroxime sodium is an organic molecular entity.
Manufacturing Process
A stirred mixture of N,N-dimethylacetamide (75 ml), acetonitrile (75 ml),
triethylamine (42 ml, 0.3 mol) and (6R,7R)-7-amino-3-carbamoyloxy-methylceph-3-em-4-carboxylic acid was immersed in an ice-bath and water
(10 ml) was added. The mixture was stirred at 0°C to 2°C for 45 minutes, the
solid slowly dissolving to give a yellow solution.
Meanwhile a stirred suspension of phosphorus pentachloride (14.99 g, 0.072
mol) in dry dichloromethane (150 ml) was cooled to 0°C, and N,N-dimethylacetamide (27.5 ml) was added. The resulting solution was recooled
to -10°C and 2-(fur-2-yl)-2-methoxyiminoacetic acid (synisomer) (12.17 g,
0.072 mol) was added. The mixture was stirred at -10°C for 15 minutes and
crushed ice (35 g) was added. The mixture was stirred at 0°C for 10minutes,
where after the lower dichloromethane phase was added over 10 minutes to
the cephalosporin solution prepared above, cooled to -10°C so that the
reaction temperature rose steadily to 0°C. The mixture was stirred at 0°C to
2°C for 1 hour, where after the cooling bath was removed and the reaction
temperature allowed to rise to 20°C over 1 hour. The reaction mixture was
then added slowly to 2 N hydrochloric acid (100 ml) diluted with cold water
(1.15 l) at 5°C. The pH of the two phase mixture was adjusted to below 2
with 2 N hydrochloric acid (10 ml), and the mixture was stirred and recooled
to 5°C. The solid which precipitated was filtered, washed with
dichloromethane (100 ml) and water (250 ml), and dried in vacuo at 40°C
overnight to give the title compound (22.04 g, 86.6%).
brand name
Kefurox (Lilly); Zinacef (GlaxoSmithKline).
Therapeutic Function
Antibiotic
Clinical Use
Cefuroxime (Zinacef) is the first of a series of α-methoximinoacyl–substituted cephalosporins that constitute most of thethird-generation agents available for clinical use. A syn alkoximinosubstituent is associated with β-lactamase stability in these cephalosporins.78 Cefuroxime is classified as a secondgenerationcephalosporin because its spectrum of antibacterialactivity more closely resembles that of cefamandole. It is,however, active against β-lactamase–producing strains thatare resistant to cefamandole, such as E. coli, K. pneumoniae,N. gonorrhoeae, and H. influenzae. Other important Gramnegativepathogens, such as Serratia, indole-positive Proteusspp., P. aeruginosa, and B. fragilis, are resistant.Cefuroxime is distributed throughout the body. It penetratesinflamed meninges in high enough concentrations tobe effective in meningitis caused by susceptible organisms.Three-times-daily dosing is required to maintain effectiveplasma levels for most sensitive organisms, such asNeisseria meningitidis, Streptococcus pneumoniae, and H.influenzae. It has a plasma half-life of 1.4 hours.
Cefuroxime sodium Preparation Products And Raw materials
Raw materials
Preparation Products
Cefuroxime sodium Suppliers
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View Lastest Price from Cefuroxime sodium manufacturers
- Product
- Cefuroxime sodium 56238-63-2
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 500kg
- Release date
- 2021-09-17
- Product
- Cefuroxime sodium 56238-63-2
- Price
- US $10.00/PCS
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2021-03-11
- Product
- Cefuroxime Sodium 56238-63-2
- Price
- US $0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2024-04-09