ChemicalBook > CAS DataBase List > 7-(TRIFLUOROMETHYL)-4-QUINOLINOL

7-(TRIFLUOROMETHYL)-4-QUINOLINOL

Product Name
7-(TRIFLUOROMETHYL)-4-QUINOLINOL
CAS No.
322-97-4
Chemical Name
7-(TRIFLUOROMETHYL)-4-QUINOLINOL
Synonyms
BUTTPARK 21\09-46;7-(trifluorophenyl)quinolin-4-ol;7-(TRIFLUOROMETHYL)-4-QUINOLINOL;4-Quinolinol, 7-(trifluoromethyl)-;7-TRIFLUOROMETHYL-4(1H)-QUINOLINONE;7-(Trifluoromethyl)-4-quinolinol,97%;7-(TRIFLUOROMETHYL)-4-QUINOLINOL 97%;7-(trifluoromethyl)-1H-quinolin-4-one;4-HYDROXY-7-(TRIFLUOROMETHYL)QUINOLINE;7-(TrifluoroMethyl)-4-hydroxy quinoline
CBNumber
CB1380866
Molecular Formula
C10H6F3NO
Formula Weight
213.16
MOL File
322-97-4.mol
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7-(TRIFLUOROMETHYL)-4-QUINOLINOL Property

Melting point:
266-269 °C(lit.)
Boiling point:
311.9±37.0 °C(Predicted)
Density 
1.3581 (estimate)
storage temp. 
2-8°C
pka
3.79±0.40(Predicted)
form 
Powder
color 
Light grayish to beige
InChIKey
OWPLFJSQLPTCHS-UHFFFAOYSA-N
CAS DataBase Reference
322-97-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29334990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
184217
Product name
4-Hydroxy-7-(trifluoromethyl)quinoline
Purity
96%
Packaging
10g
Price
$153
Updated
2023/06/20
TRC
Product number
T797070
Product name
7-(Trifluoromethyl)-4-quinolinol
Packaging
100mg
Price
$75
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-3-74
Product name
4-Hydroxy-7-(trifluoromethyl)quinoline
Purity
98%
Packaging
1g
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
005411
Product name
7-(Trifluoromethyl)-4-quinolinol
Purity
98%
Packaging
5g
Price
$94
Updated
2021/12/16
Matrix Scientific
Product number
005411
Product name
7-(Trifluoromethyl)-4-quinolinol
Purity
98%
Packaging
1g
Price
$29
Updated
2021/12/16
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7-(TRIFLUOROMETHYL)-4-QUINOLINOL Chemical Properties,Usage,Production

Chemical Properties

Light greyish-beige powder

Uses

4-Hydroxy-7-(trifluoromethyl)quinoline was used in the synthesis of 4[[7-(trifluoromethyl)quinolin-4-yl]oxy]pthalonitrile.

Definition

ChEBI: 7-(trifluoromethyl)-1H-quinolin-4-one is a member of quinolines.

Synthesis

391-02-6

322-97-4

General procedure for the synthesis of 4-hydroxy-7-(trifluoromethyl)quinoline-3-carboxylic acid from ethyl 4-hydroxy-7-(trifluoromethyl)quinoline-3-carboxylate: Compound I-D (5 g) and potassium hydroxide (3 equiv.) were dissolved in 60 ml of a solvent mixture of water and ethylene glycol (1:1) in a sealed XP-500 Plus container. The reaction was microwave heated at 200°C and 220-240 psi pressure for 30 minutes using a MARS 5 microwave system. After completion of the reaction, the mixture was cooled to room temperature and poured into 100 ml of water. The solution was acidified to pH ≈ 6 with 2N hydrochloric acid, subsequently saturated with sodium chloride and extracted with tetrahydrofuran (3 x 200 ml). The organic layers were combined, washed with brine and concentrated to give compounds I-E in over 80% yield.

References

[1] Patent: WO2005/63739, 2005, A1. Location in patent: Page/Page column 45-46
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 25, p. 4918 - 4926
[3] Journal of the American Chemical Society, 1947, vol. 69, p. 371,373

7-(TRIFLUOROMETHYL)-4-QUINOLINOL Preparation Products And Raw materials

Raw materials

Hexane Nitrogen Diethyl ethoxymethylenemalonate Diphenyl ether Hydrochloric acid Methanol Sodium hydroxide 3-Aminobenzotrifluoride

Preparation Products

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View Lastest Price from 7-(TRIFLUOROMETHYL)-4-QUINOLINOL manufacturers

Career Henan Chemical Co
Product
7-(TRIFLUOROMETHYL)-4-QUINOLINOL 322-97-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-24

322-97-4, 7-(TRIFLUOROMETHYL)-4-QUINOLINOLRelated Search:

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  • 7-TRIFLUOROMETHYL-4(1H)-QUINOLINONE
  • 7-(TRIFLUOROMETHYL)-4-QUINOLINOL
  • 4-HYDROXY-7-(TRIFLUOROMETHYL)QUINOLINE
  • BUTTPARK 21\09-46
  • 7-(2,3,4-trifluorophenyl)-1H-quinolin-4-one
  • 7-(trifluorophenyl)quinolin-4-ol
  • 4-Hydroxy-7-(trifluoromethyl)quinoline 98%
  • 4-Hydroxy-7-(trifluoromethyl)quinoline98%
  • 7-(TRIFLUOROMETHYL)-4-QUINOLINOL 97%
  • 7-(Trifluoromethyl)-4-quinolinol,97%
  • 7-(TrifluoroMethyl)-4-hydroxy quinoline
  • 4-Quinolinol, 7-(trifluoromethyl)-
  • 7-(trifluoromethyl)-1H-quinolin-4-one
  • 7-(TRIFLUOROMETHYL)-4-QUINOLINOL ISO 9001：2015 REACH
  • 322-97-4
  • ALCOHOL
  • Building Blocks
  • Heterocyclic Building Blocks
  • Quinolines
  • Building Blocks
  • C8 to C10
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • Quinolines
  • API intermediates
  • quinoline