Ibrutinib Impurity 9

Product Name: Ibrutinib Impurity 9
CAS No.: 2068022-09-1
Chemical Name: Ibrutinib Impurity 9
Synonyms: Ibrutinib Impurity 3-d5;N-(1-((S)-1-acryloylpiperidin-3-yl)-;Ibrutinib Impurity 3-d5 (PCI-45227-d5);Ibrutinib Impurity 3-d5 (PCI-45227-d5)(Mixture of Diastereomers);1-((R)-3-(4-Amino-3-(4-(phenoxy-d5)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2,3-dihydroxypropan-1-one;1-[(3R)-3-[4-amino-3-[4-(2,3,4,5,6-pentadeuteriophenoxy)phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-2,3-dihydroxypropan-1-one
CBNumber: CB13879189
Molecular Formula: C25H21D5N6O4
Formula Weight: 479.54254889
MOL File: 2068022-09-1.mol

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Hazard and Precautionary Statements (GHS)

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Ibrutinib Impurity 9 Chemical Properties,Usage,Production

Uses

Dihydrodiol-Ibrutinib-d5 is the deuterium labeled Dihydrodiol-Ibrutinib (HY-100659). Dihydrodiol-Ibrutinib is a dihydrodiol active metabolite of Ibrutinib (HY-10997), has inhibitory activity towards BTK approximately 15 times lower than that of ibrutinib[1].

References

[1] Sridhar Veeraraghavan,et al. Simultaneous quantification of lenalidomide, ibrutinib and its active metabolite PCI-45227 in rat plasma by LC-MS/MS: application to a pharmacokinetic study. J Pharm Biomed Anal DOI:10.1016/j.jpba.2014.11.041

Ibrutinib Impurity 9 Preparation Products And Raw materials

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Ibrutinib Impurity 9 Suppliers

China 3 India 1 Global 4

Daicel Chiral Technologies (China)CO.,LTD

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Hubei Moco Chemical Co., Ltd.

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2068022-09-1, Ibrutinib Impurity 9Related Search:

Ceritinib (LDK378) Cabozantinib LOXO-101 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine (S)-Ibrutinib Dihydrodiol Ibrutinib Ibrutinib D5 5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMine 1,3-bis((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-piperidin-1-yl)propan-1-one (S)-1-Boc-3-hydroxypiperidine (R)-1-[3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-3-chloropropan-1-one Ibrutinib

1-[(3R)-3-[4-amino-3-[4-(2,3,4,5,6-pentadeuteriophenoxy)phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-2,3-dihydroxypropan-1-one

Ibrutinib Impurity 3-d5

N-(1-((S)-1-acryloylpiperidin-3-yl)-

Ibrutinib Impurity 3-d5 (PCI-45227-d5)(Mixture of Diastereomers)

1-((R)-3-(4-Amino-3-(4-(phenoxy-d5)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2,3-dihydroxypropan-1-one

Ibrutinib Impurity 3-d5 (PCI-45227-d5)

2068022-09-1