ChemicalBook > CAS DataBase List > (S)-(-)-1-(2-Naphthyl)ethylamine

(S)-(-)-1-(2-Naphthyl)ethylamine

Product Name
(S)-(-)-1-(2-Naphthyl)ethylamine
CAS No.
3082-62-0
Chemical Name
(S)-(-)-1-(2-Naphthyl)ethylamine
Synonyms
(S)-1-(naphthalen-2-yl)ethan-1-amine;A4900;Evocalcet Impurity 19;Cinacalcet Impurity 100;(S)-1-(2-NAPHTHYL)ETHYLAMINE;(S)-2-(1-Aminoethyl)naphthalene;(S)-1-(2-Naphthyl)ethylamine>(S)-(-)-1-(2-NAPHTHYL)ETHYLAMINE;(S)-(-)-A-(2-NAPHTHYL)ETHYLAMINE;(1S)-1-naphthalen-2-ylethanamine
CBNumber
CB1390324
Molecular Formula
C12H13N
Formula Weight
171.24
MOL File
3082-62-0.mol
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(S)-(-)-1-(2-Naphthyl)ethylamine Property

Melting point:
47-50 °C
Boiling point:
90°C 0,15mm
alpha 
-21 º (C=1%, IN MEOH)
Density 
1.064±0.06 g/cm3(Predicted)
refractive index 
-20 ° (C=1, MeOH)
Flash point:
90°C/0.15mm
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
powder to crystal
pka
9.36±0.40(Predicted)
color 
White to Light yellow
optical activity
[α]20/D 21±1°, c = 1% in methanol
Water Solubility 
Insoluble in water.
Sensitive 
Air Sensitive
BRN 
3195949
InChIKey
KHSYYLCXQKCYQX-VIFPVBQESA-N
CAS DataBase Reference
3082-62-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,N
Risk Statements 
36/37/38-51/53
Safety Statements 
26-36-61
RIDADR 
2923
WGK Germany 
3
F 
10-34
HazardClass 
8
PackingGroup 
III
HS Code 
2921490090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
70942
Product name
(S)-(?)-1-(2-Naphthyl)ethylamine
Purity
≥99.0% (sum of enantiomers, GC)
Packaging
1g
Price
$153
Updated
2025/07/31
TCI Chemical
Product number
N0726
Product name
(S)-1-(2-Naphthyl)ethylamine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$69
Updated
2025/07/31
TCI Chemical
Product number
N0726
Product name
(S)-1-(2-Naphthyl)ethylamine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$208
Updated
2025/07/31
TRC
Product number
N325068
Product name
(S)-(-)-1-(2-Naphthyl)ethylamine
Packaging
50mg
Price
$60
Updated
2021/12/16
Chem-Impex
Product number
37505
Product name
(S)-1-(2-Naphthyl)ethylamine,98%(GC)(T)
Purity
98%(GC)(T)
Packaging
5G
Price
$148.96
Updated
2021/12/16
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(S)-(-)-1-(2-Naphthyl)ethylamine Chemical Properties,Usage,Production

Uses

(S)-(-)-1-(2-Naphthyl)ethylamine is used in asymmetric synthesis. It is also used in the preparation of thiourea compounds using chiral amine, which is used as a bifunctional catalyst for the Strecker and nitro-Michael reactions. Further, it acts as a chiral building block and chiral resolution reagent.

Synthesis

1201-74-7

98-88-4

114459-78-8

3976-23-6

3082-62-0

1201-74-7

GENERAL METHODS: N-acylation reactions were carried out in cyclohexane in the presence or absence of TIPS-β-CD with racemic 1-(naphthalen-2-yl)ethylamine (1), (S)-(-)-1-(2-naphthalenyl)ethylamine (2), and 1-(naphthalen-2-yl)ethylamine (3) as the substrates, benzoyl chloride (4a-j) as the acylation reagent, and triethylamine as the base. First, racemic 1, 2, and 3 (6.0 × 10^-4 mmol) were mixed with 6-O-methylsilylated β-CD in cyclohexane (600 μL) and stirred for 1 h to reach complexation equilibrium. Subsequently, 6-O-methylsilylated β-CD, triethylamine (6.0 x 10^-4 mmol) and chloroyl chloride 4a-j were added at 10 °C. The reaction mixture was continued to be stirred for 6 h at 10 °C. Upon completion of the reaction, the product was analyzed by high performance liquid chromatography (HPLC) using a Diacel Chiralcel OD-H chiral column (250 mm × 4.6 mm I.D.) with hexane/2-propanol (80:20 or 95:5) as eluent at a flow rate of 0.5 or 1.5 mL/min and a UV detector (254 nm). The HPLC profiles of the N-acylation reaction products of 1, 2, and 3 with chloroyl chloride 4a-j (3.3 × 10^-4 mmol) in cyclohexane (600 μL), including triethylamine (6.0 × 10^-4 mmol), in the absence and presence of TIPS-β-CD (3.0 × 10^-3 mmol) are shown in Figures 1 and 2, and S18-26, respectively in.

References

[1] Tetrahedron, 2014, vol. 70, # 2, p. 197 - 203

(S)-(-)-1-(2-Naphthyl)ethylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (S)-(-)-1-(2-Naphthyl)ethylamine manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
(S)-(-)-1-(2-Naphthyl)ethylamine 3082-62-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-17
Shaanxi Dideu Medichem Co. Ltd
Product
(S)-(-)-1-(2-Naphthyl)ethylamine 3082-62-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2024-08-04
Zhuozhou Wenxi import and Export Co., Ltd
Product
(S)-(-)-1-(2-Naphthyl)ethylamine 3082-62-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11

3082-62-0, (S)-(-)-1-(2-Naphthyl)ethylamineRelated Search:

Etamsylate Triethylamine Ethambutol Ethylamine Triethylamine hydrochloride L-1-Phenylethylamine Diethylamine 1-(1-NAPHTHYL)-2-THIOUREA 3-(3-Trifluoromethyl-phenyl)-prop-2-en-1-ol 4-NITROPHENYL PHENYL SULFIDE Ethanone, 1-(1-naphthalenyl)-, oxiMe Benzenemethanol, 3-(trifluoromethyl)-, 1-(4-methylbenzenesulfonate) SEVZPXQQXHZTBG-JKSUJKDBSA-N Benzenepropanol, 3-methyl-, 1-(4-methylbenzenesulfonate) 3-(4-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL 1-(NAPHTHALEN-1-YL)ETHANONE OXIME 3-Phenylpropionic acid methyl ester 3-(3-Trifluoromethylphenyl)propionic acid

  • (S)-(-)-1-(2-NAPHTHYL)ETHYLAMINE
  • (S)-1-(2-NAPHTHYL)ETHYLAMINE
  • (S)-1-(NAPHTHALEN-2-YL)ETHANAMINE
  • (S)-(-)-A-(2-NAPHTHYL)ETHYLAMINE
  • (s)-(-)-α-methyl-2-naphthalenemethylamine
  • (S)-(-)-1-(2-NAPHTHYL)ETHYLAMINE: CHIPROS 99%, EE 99%
  • (S)-(-)-1-(2-NAPHTHYL)ETHYLAMINE, CHIPROS 99+%, EE 99+%
  • (S)-2-(1-Aminoethyl)naphthalene
  • (S)-(-)-1-(2-Naphthyl)ethylamine,ChiPros
  • (1S)-1-(naphthalen-2-yl)ethan-1-amine
  • (S)-(-)-1-(2-NAPHTHYL)ETHYLAMINE-HCL
  • (S)-(-)-1-(2-Naphthyl)ethylamine ChiPros(R), produced by BASF, >=98.5%
  • (S)-(-)-1-(2-Naphthyl)ethylamine, 99%, ee 99%
  • (<i>S</i>)-1-(2-Naphthyl)ethylamine
  • (1S)-1-naphthalen-2-ylethanamine
  • (S)-1-(naphthalen-2-yl)ethan-1-amine
  • A4900
  • (S)-1-(2-Naphthyl)ethylamine&gt
  • 2-Naphthalenemethanamine, α-methyl-, (αS)-
  • (S)-(-)-1-(2-Naphthyl)ethylamine ISO 9001：2015 REACH
  • Cinacalcet Impurity 100
  • (S)-(-)-1-(Naphthalen-2-yl)ethylamine
  • Evocalcet Impurity 19
  • 1-(4-ethoxy-2-methylphenyl)ethan-1-amine hydrochloride
  • 3082-62-0
  • Chiral Resolution Reagents
  • Asymmetric Synthesis
  • Chiral Resolving Reagents
  • Amines (Chiral)
  • Chiral Building Blocks
  • Synthetic Organic Chemistry