(S)-(-)-1-(2-Naphthyl)ethylamine
- Product Name
- (S)-(-)-1-(2-Naphthyl)ethylamine
- CAS No.
- 3082-62-0
- Chemical Name
- (S)-(-)-1-(2-Naphthyl)ethylamine
- Synonyms
- (S)-1-(naphthalen-2-yl)ethan-1-amine;A4900;Evocalcet Impurity 19;Cinacalcet Impurity 100;(S)-1-(2-NAPHTHYL)ETHYLAMINE;(S)-2-(1-Aminoethyl)naphthalene;(S)-1-(2-Naphthyl)ethylamine>(S)-(-)-1-(2-NAPHTHYL)ETHYLAMINE;(S)-(-)-A-(2-NAPHTHYL)ETHYLAMINE;(1S)-1-naphthalen-2-ylethanamine
- CBNumber
- CB1390324
- Molecular Formula
- C12H13N
- Formula Weight
- 171.24
- MOL File
- 3082-62-0.mol
(S)-(-)-1-(2-Naphthyl)ethylamine Property
- Melting point:
- 47-50 °C
- Boiling point:
- 90°C 0,15mm
- alpha
- -21 º (C=1%, IN MEOH)
- Density
- 1.064±0.06 g/cm3(Predicted)
- refractive index
- -20 ° (C=1, MeOH)
- Flash point:
- 90°C/0.15mm
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- powder to crystal
- pka
- 9.36±0.40(Predicted)
- color
- White to Light yellow
- optical activity
- [α]20/D 21±1°, c = 1% in methanol
- Water Solubility
- Insoluble in water.
- Sensitive
- Air Sensitive
- BRN
- 3195949
- InChIKey
- KHSYYLCXQKCYQX-VIFPVBQESA-N
- CAS DataBase Reference
- 3082-62-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,N
- Risk Statements
- 36/37/38-51/53
- Safety Statements
- 26-36-61
- RIDADR
- 2923
- WGK Germany
- 3
- F
- 10-34
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 2921490090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 70942
- Product name
- (S)-(?)-1-(2-Naphthyl)ethylamine
- Purity
- ≥99.0% (sum of enantiomers, GC)
- Packaging
- 1g
- Price
- $153
- Updated
- 2025/07/31
- Product number
- N0726
- Product name
- (S)-1-(2-Naphthyl)ethylamine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $69
- Updated
- 2025/07/31
- Product number
- N0726
- Product name
- (S)-1-(2-Naphthyl)ethylamine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $208
- Updated
- 2025/07/31
- Product number
- N325068
- Product name
- (S)-(-)-1-(2-Naphthyl)ethylamine
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 37505
- Product name
- (S)-1-(2-Naphthyl)ethylamine,98%(GC)(T)
- Purity
- 98%(GC)(T)
- Packaging
- 5G
- Price
- $148.96
- Updated
- 2021/12/16
(S)-(-)-1-(2-Naphthyl)ethylamine Chemical Properties,Usage,Production
Uses
(S)-(-)-1-(2-Naphthyl)ethylamine is used in asymmetric synthesis. It is also used in the preparation of thiourea compounds using chiral amine, which is used as a bifunctional catalyst for the Strecker and nitro-Michael reactions. Further, it acts as a chiral building block and chiral resolution reagent.
Synthesis
1201-74-7
98-88-4
114459-78-8
3976-23-6
3082-62-0
1201-74-7
GENERAL METHODS: N-acylation reactions were carried out in cyclohexane in the presence or absence of TIPS-β-CD with racemic 1-(naphthalen-2-yl)ethylamine (1), (S)-(-)-1-(2-naphthalenyl)ethylamine (2), and 1-(naphthalen-2-yl)ethylamine (3) as the substrates, benzoyl chloride (4a-j) as the acylation reagent, and triethylamine as the base. First, racemic 1, 2, and 3 (6.0 × 10^-4 mmol) were mixed with 6-O-methylsilylated β-CD in cyclohexane (600 μL) and stirred for 1 h to reach complexation equilibrium. Subsequently, 6-O-methylsilylated β-CD, triethylamine (6.0 x 10^-4 mmol) and chloroyl chloride 4a-j were added at 10 °C. The reaction mixture was continued to be stirred for 6 h at 10 °C. Upon completion of the reaction, the product was analyzed by high performance liquid chromatography (HPLC) using a Diacel Chiralcel OD-H chiral column (250 mm × 4.6 mm I.D.) with hexane/2-propanol (80:20 or 95:5) as eluent at a flow rate of 0.5 or 1.5 mL/min and a UV detector (254 nm). The HPLC profiles of the N-acylation reaction products of 1, 2, and 3 with chloroyl chloride 4a-j (3.3 × 10^-4 mmol) in cyclohexane (600 μL), including triethylamine (6.0 × 10^-4 mmol), in the absence and presence of TIPS-β-CD (3.0 × 10^-3 mmol) are shown in Figures 1 and 2, and S18-26, respectively in.
References
[1] Tetrahedron, 2014, vol. 70, # 2, p. 197 - 203
(S)-(-)-1-(2-Naphthyl)ethylamine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (S)-(-)-1-(2-Naphthyl)ethylamine manufacturers
- Product
- (S)-(-)-1-(2-Naphthyl)ethylamine 3082-62-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-17
- Product
- (S)-(-)-1-(2-Naphthyl)ethylamine 3082-62-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-08-04
- Product
- (S)-(-)-1-(2-Naphthyl)ethylamine 3082-62-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11