ChemicalBook > CAS DataBase List > 3,4-Dichloro-1,2,5-thiadiazole

3,4-Dichloro-1,2,5-thiadiazole

Product Name: 3,4-Dichloro-1,2,5-thiadiazole
CAS No.: 5728-20-1
Chemical Name: 3,4-Dichloro-1,2,5-thiadiazole
Synonyms: DCTD;AI3-61900;BB_SC-3458;ZINC04529131;258903_ALDRICH;EINECS 227-232-7;4ETHYL4AMINOBIPHENYL;4'-Ethyl-4-biphenylamine;3,4-Dichlor-1,2,5-thiadiazol;,4-Dichloro-1,2,5-thiadiazole
CBNumber: CB1390399
Molecular Formula: C2Cl2N2S
Formula Weight: 155.01
MOL File: 5728-20-1.mol

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3,4-Dichloro-1,2,5-thiadiazole Property

Melting point:: 82-83 °C
Boiling point:: 158 °C (lit.)
Density: 1.648 g/mL at 25 °C (lit.)
refractive index: 1.561
Flash point:: >100°C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Soluble in chloroform and methanol.
pka: -3.82±0.10(Predicted)
form: Oil
color: Colorless
Sensitive: Hygroscopic
BRN: 606585
InChI: InChI=1S/C2Cl2N2S/c3-1-2(4)6-7-5-1
InChIKey: YNZQOVYRCBAMEU-UHFFFAOYSA-N
SMILES: S1N=C(Cl)C(Cl)=N1
CAS DataBase Reference: 5728-20-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
RIDADR: UN2810
WGK Germany: 2
HazardClass: 6.1
PackingGroup: III
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 258903
Product name: 3,4-Dichloro-1,2,5-thiadiazole
Purity: 97%
Packaging: 10g
Price: $62
Updated: 2025/07/31

Sigma-Aldrich

Product number: 258903
Product name: 3,4-Dichloro-1,2,5-thiadiazole
Purity: 97%
Packaging: 50g
Price: $206
Updated: 2025/07/31

TCI Chemical

Product number: D3547
Product name: 3,4-Dichloro-1,2,5-thiadiazole
Purity: >98.0%(GC)
Packaging: 25g
Price: $58
Updated: 2025/07/31

TRC

Product number: D435985
Product name: 3,4-Dichloro-1,2,5-thiadiazole
Packaging: 50g
Price: $80
Updated: 2021/12/16

TRC

Product number: D435985
Product name: 3,4-Dichloro-1,2,5-thiadiazole
Packaging: 100g
Price: $140
Updated: 2021/12/16

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3,4-Dichloro-1,2,5-thiadiazole Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid

Uses

3,4-Dichloro-1,2,5-thiadiazole is a chlorinated thiadiazole that is a potent inhibitors of nitrification in soil. 3,4-Dichloro-1,2,5-thiadiazole is used as a building block in the preparaton of the β-adrenergic blocking agent, Timolol.

Uses

3,4-Dichloro-1,2,5-thiadiazole has been employed:

as guest molecule to investigate solid-state 13C NMR spectra of inclusion compounds of 2,6-dimethyl-bicyclo[3.3.1]nonane-exo-2-exo-6-diol with small organic molecules
in preparation of [1,2,5]thiadiazol-3-yl-piperazine compounds

Synthesis Reference(s)

Tetrahedron Letters, 15, p. 1687, 1974 DOI: 10.1016/S0040-4039(01)82554-5

Synthesis

2038-44-0

5728-20-1

GENERAL PROCEDURE: The reaction system was cooled to -25°C under argon protection, followed by the slow dropwise addition of disulfur dichloride (S2Cl2, 0.64 mL, 8.00 mmol) to a solution of anhydrous acetonitrile (10 mL) containing o-dichloroacetaldioxime (2.0 mmol) and pyridine (0.80 mL, 10.0 mmol) while stirring was maintained. After dropwise addition, the reaction mixture was gradually warmed to room temperature and continued stirring for 1 hour, followed by heating to reflux state for 4 hours. Upon completion of the reaction, the mixture was filtered to remove insoluble material and the filtrate was concentrated under reduced pressure to remove solvent. The resulting crude product was purified by column chromatography (silica gel Merck 60, eluent was a solvent mixture of hexane/dichloromethane) to afford the target product 3,4-dichloro-1,2,5-thiadiazole.

References

[1] Tetrahedron, 2014, vol. 70, # 35, p. 5558 - 5568
[2] Journal of Organic Chemistry, 1970, vol. 35, p. 1165 - 1169

3,4-Dichloro-1,2,5-thiadiazole Preparation Products And Raw materials

Raw materials

Ammonium chloride

Preparation Products

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View Lastest Price from 3,4-Dichloro-1,2,5-thiadiazole manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 3,4-Dichloro-1,2,5-thiadiazole 5728-20-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-05-26

Career Henan Chemical Co

Product: 3,4-Dichloro-1,2,5-thiadiazole 5728-20-1
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: as request
Release date: 2018-12-24

5728-20-1, 3,4-Dichloro-1,2,5-thiadiazoleRelated Search:

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258903_ALDRICH

AI3-61900

BB_SC-3458

EINECS 227-232-7

ZINC04529131

3,4-Dichloro-1,2,5-thiadiazole&gt

4'-Ethyl-4-biphenylamine

5728-20-1

C2Cl2N2S

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