ChemicalBook > CAS DataBase List > L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID

L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID

Product Name
L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID
CAS No.
42438-90-4
Chemical Name
L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID
Synonyms
TCR;TNCA;L -CarL;H-TPI-OH;H-THNH(3)-OH;Lycoperodine 1;TNCA >=98% (HPLC);RARECHEM BK PT 0088;CYCLOMETHYLTRYPTOPHAN;Tryptophan Impurity M
CBNumber
CB1395455
Molecular Formula
C12H12N2O2
Formula Weight
216.24
MOL File
42438-90-4.mol
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L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID Property

Melting point:
289 °C (dec.)(lit.)
Boiling point:
485.0±45.0 °C(Predicted)
Density 
1.377±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
soluble1.5mg/mL, clear (Solvent: 0.1N HCl:DMSO (1:1); warmed)
pka
2.28±0.20(Predicted)
form 
powder
color 
white to beige
optical activity
[α]/D -57 to -67°, c = 1 (in MeOH:1N HCl (1:1))
InChIKey
FSNCEEGOMTYXKY-JTQLQIEISA-N
CAS DataBase Reference
42438-90-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P233Keep container tightly closed.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304IF INHALED:

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P340Remove victim to fresh air and keep at rest in a position comfortable for breathing.

P362Take off contaminated clothing and wash before reuse.

P403Store in a well-ventilated place.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1711
Product name
(S)-(?)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
Purity
≥98% (HPLC)
Packaging
10mg
Price
$58.5
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1711
Product name
(S)-(?)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
Purity
≥98% (HPLC)
Packaging
50mg
Price
$240
Updated
2025/07/31
TCI Chemical
Product number
T4198
Product name
H-Tpi-OH
Packaging
200MG
Price
$83
Updated
2025/07/31
TCI Chemical
Product number
T4198
Product name
H-Tpi-OH
Packaging
1G
Price
$249
Updated
2025/07/31
TRC
Product number
T795458
Product name
L-1,2,3,4-Tetrahydronorharman-3-carboxylicAcid
Packaging
200mg
Price
$160
Updated
2021/12/16
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L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Uses

Lycoperodine-1 (Cyclomethyltryptophan) is an active product that can be isolated from tomato fruits (Lycopersicon sculentum). Lycoperodine-1 act as an agonist of Ca2+ sensing receptors (CaSR)[1].

Biochem/physiol Actions

TNCA is a tryptophan derivative that binds the parathyroid Ca2+-sensing receptor (CaSR) extracellular domain (ECD) hinge region between two globular subdomains and acts as a high-affinity CaSR ligand (CaSRL) with co-agonist activity. TNCA is shown to potentiate both Mg++- and Ca++-evoked cellular calcium response (0.1-0.5 mM), as well as Mg++-evoked cellular ERK1/2 phosphorylation in CaSR-expressing HEK293 cells (0.5 mM). AC-265347 (Cat. No. SML0129), on the other hand, is a calcimimetic that functions as a CaSR agonist.

References

[1] Shoji Yahara, et al. Steroidal Alkaloid Glycosides from Tomato (Lycopersicon esculentum). J Nat Prod. 2004 Mar;67(3):500-2. DOI:10.1021/np030382x

L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID Suppliers

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42438-90-4, L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACIDRelated Search:

BOC-D-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID FMOC-D-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID 1,2,3,4-TETRAHYDRO-9H-PYRIDO[3,4-B]INDOLE (S)-1,2,3,4-Tetrahydronorharman-3-carboxylic acid, N2-FMOC protected,FMOC-L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID BOC-L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID (1S,3S)-2,3,4,9-TETRAHYDRO-1-METHYL-1H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID (1S,3S)-1-ETHYL-2,3,4,9-TETRAHYDRO-1H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID BOC-TPI(FOR)-OH L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID FMOC-DL-6-METHOXY-1,2,3,4-TETRAHYDRONORHARMAN-1-CARBOXYLIC ACID BOC-DL-6-METHOXY-1,2,3,4-TETRAHYDRONORHARMAN-1-CARBOXYLIC ACID D-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID CIS-1-(1,3-BENZODIOXOL-5-YL)-2-(CHLOROACETYL)-2,3,4,9-TETRAHYDRO-, 1H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID METHYL ESTER 9-FORMYL-1,2,3,4-TETRAHYDRONORHARMAN-L-3-CARBOXYLIC ACID HYDROCHLORIDE 1,3,4,9-TETRAHYDRO-B-CARBOLINE-2-CARBOXYLIC ACID METHYL ESTER HCL L-1,2,3,4-TETRAHYDRONORHARMANE-3-CARBOXYLIC ACID ETHYL ESTER HYDROCHLORIDE N-ALPHA-CARBOBENZOXY-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID H-TPI-OME

  • L-TRYPTOLINE-3-CARBOXYLIC ACID
  • H-TPI-OH
  • H-THNH(3)-OH
  • L-2,3,4-TETRAHYDRO-BETA-CARBOLINE-3-CARBOXYLIC ACID
  • L-1,2,3,4-TETRAHYDRO-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID
  • L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID
  • 1,2,3,4-TETRAHYDRONORHARMAN-L-3-CARBOXYLIC ACID
  • RARECHEM BK PT 0088
  • (S)-2,3,4,9-TETRAHYDRO-1H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID
  • L-1,2,3,4-tetrahydronorharmane-3-carboxylic acid
  • L-1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole-3-carb
  • 2,3,4,9-Tetrahydro-1H-β-carboline-3-carboxylic acid
  • (3S)-1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid
  • (3S)-1,2,3,4-Tetrahydro-β-carboline-3α-carboxylic acid
  • (3S)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3α-carboxylic acid
  • (S)-1,2,3,4-Tetrahydro-β-carboline-3-carboxylic acid
  • (3S)-1H,2H,3H,4H,9H-pyrido[3,4-b]indole-3-carboxylic acid
  • TNCA
  • 4-b]indole-3-carboxylic acid
  • 4-Tetrahydro-9H-pyrido[3
  • 4-Tetrahydro-b-carboline-3-carboxylic acid
  • 9-Tetrahydro-1H-beta-carboline-3-carboxylic acid
  • L -CarL
  • Lycoperodine 1
  • (3S)-2,3,4,9-Tetrahydro-1H-beta-carboline-3-carboxylic acid
  • L-1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid, L-Tryptoline-3-carboxylic acid, H-Tpi-OH, L-1,2,3,4-Tetrahydro-b-carboline-3-carboxylic acid
  • (3S)-1,3,4,9-tetrahydro-$b-carbolin-2-ium-3-carboxylate
  • (3S)-1,3,4,9-tetrahydropyrido[5,4-b]indol-2-ium-3-carboxylate
  • (3S)-2,3,4,9-tetrahydro-1H-$b-carboline-3-carboxylic acid
  • (3S)-2,3,4,9-tetrahydro-1H-pyrido[5,4-b]indole-3-carboxylic acid
  • CYCLOMETHYLTRYPTOPHAN
  • TCR
  • (S)-1,2,3,4-Tetrahydronorharmane-3-carboxylic acid
  • 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2,3,4,9-tetrahydro-, (3S)-
  • L-1,2,3,4-Tetrahydro-β-carbolin-3-carboxylic acid
  • TNCA >=98% (HPLC)
  • Tryptophan Impurity M
  • (S)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid - [T91715]
  • (3S)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
  • 42438-90-4
  • 2438-90-4
  • C12H12NO2
  • Phenylalanine analogs and other aromatic alpha amino acids
  • 1