ChemicalBook > CAS DataBase List > L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID

L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID

Product Name
L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID
CAS No.
42438-90-4
Chemical Name
L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID
Synonyms
TCR;TNCA;L -CarL;H-TPI-OH;H-THNH(3)-OH;Lycoperodine 1;TNCA >=98% (HPLC);RARECHEM BK PT 0088;CYCLOMETHYLTRYPTOPHAN;Tryptophan Impurity M
CBNumber
CB1395455
Molecular Formula
C12H12N2O2
Formula Weight
216.24
MOL File
42438-90-4.mol
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L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID Property

Melting point:
289 °C (dec.)(lit.)
Boiling point:
485.0±45.0 °C(Predicted)
Density 
1.377±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
soluble1.5mg/mL, clear (Solvent: 0.1N HCl:DMSO (1:1); warmed)
pka
2.28±0.20(Predicted)
form 
powder
color 
white to beige
optical activity
[α]/D -57 to -67°, c = 1 (in MeOH:1N HCl (1:1))
InChIKey
FSNCEEGOMTYXKY-JTQLQIEISA-N
CAS DataBase Reference
42438-90-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P233Keep container tightly closed.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304IF INHALED:

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P340Remove victim to fresh air and keep at rest in a position comfortable for breathing.

P362Take off contaminated clothing and wash before reuse.

P403Store in a well-ventilated place.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1711
Product name
(S)-(?)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
Purity
≥98% (HPLC)
Packaging
10mg
Price
$56.9
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1711
Product name
(S)-(?)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
Purity
≥98% (HPLC)
Packaging
50mg
Price
$233
Updated
2024/03/01
TRC
Product number
T795458
Product name
L-1,2,3,4-Tetrahydronorharman-3-carboxylicAcid
Packaging
200mg
Price
$160
Updated
2021/12/16
AK Scientific
Product number
Z5873
Product name
(S)-(?)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
Packaging
1g
Price
$77
Updated
2021/12/16
Chem-Impex
Product number
06279
Product name
L-1,2,3,4-Tetrahydronorharman-3-carboxylicacid,98%
Purity
98%
Packaging
5G
Price
$78.4
Updated
2021/12/16
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L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Biochem/physiol Actions

TNCA is a tryptophan derivative that binds the parathyroid Ca2+-sensing receptor (CaSR) extracellular domain (ECD) hinge region between two globular subdomains and acts as a high-affinity CaSR ligand (CaSRL) with co-agonist activity. TNCA is shown to potentiate both Mg++- and Ca++-evoked cellular calcium response (0.1-0.5 mM), as well as Mg++-evoked cellular ERK1/2 phosphorylation in CaSR-expressing HEK293 cells (0.5 mM). AC-265347 (Cat. No. SML0129), on the other hand, is a calcimimetic that functions as a CaSR agonist.

L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID Suppliers

China 76 Germany 5 India 2 Japan 3 Switzerland 1 United Kingdom 1 United States 19 Global 107
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
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China
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40228
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Shanghai HC Biotech Co., Ltd
Tel
021-20227858
Fax
+86-21-20227857
Email
sale@hcbiotech.com.cn
Country
China
ProdList
1095
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Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
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Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
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60
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
021-51613915-820 13611835272
Fax
021 51613951
Email
mmwang@sunwaypharm.cn
Country
China
ProdList
9734
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Shenzhen Sungening Bio-Tech Co., Ltd
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+86-0755-89668383
Fax
+86-0755-89594066/4038
Email
sales@sungening.com
Country
China
ProdList
1319
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Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
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China
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12335
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9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
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56
Amatek Scientific Co. Ltd.
Tel
0512-56316828 4008675858
Fax
+86-512-56316826
Email
sales@amateksci.com
Country
China
ProdList
9894
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55
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
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60

42438-90-4, L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACIDRelated Search:

BOC-D-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID FMOC-D-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID 1,2,3,4-TETRAHYDRO-9H-PYRIDO[3,4-B]INDOLE (S)-1,2,3,4-Tetrahydronorharman-3-carboxylic acid, N2-FMOC protected,FMOC-L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID BOC-L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID (1S,3S)-2,3,4,9-TETRAHYDRO-1-METHYL-1H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID (1S,3S)-1-ETHYL-2,3,4,9-TETRAHYDRO-1H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID BOC-TPI(FOR)-OH L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID FMOC-DL-6-METHOXY-1,2,3,4-TETRAHYDRONORHARMAN-1-CARBOXYLIC ACID BOC-DL-6-METHOXY-1,2,3,4-TETRAHYDRONORHARMAN-1-CARBOXYLIC ACID D-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID CIS-1-(1,3-BENZODIOXOL-5-YL)-2-(CHLOROACETYL)-2,3,4,9-TETRAHYDRO-, 1H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID METHYL ESTER 9-FORMYL-1,2,3,4-TETRAHYDRONORHARMAN-L-3-CARBOXYLIC ACID HYDROCHLORIDE 1,3,4,9-TETRAHYDRO-B-CARBOLINE-2-CARBOXYLIC ACID METHYL ESTER HCL L-1,2,3,4-TETRAHYDRONORHARMANE-3-CARBOXYLIC ACID ETHYL ESTER HYDROCHLORIDE N-ALPHA-CARBOBENZOXY-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID H-TPI-OME

  • L-TRYPTOLINE-3-CARBOXYLIC ACID
  • H-TPI-OH
  • H-THNH(3)-OH
  • L-2,3,4-TETRAHYDRO-BETA-CARBOLINE-3-CARBOXYLIC ACID
  • L-1,2,3,4-TETRAHYDRO-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID
  • L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID
  • 1,2,3,4-TETRAHYDRONORHARMAN-L-3-CARBOXYLIC ACID
  • RARECHEM BK PT 0088
  • (S)-2,3,4,9-TETRAHYDRO-1H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID
  • L-1,2,3,4-tetrahydronorharmane-3-carboxylic acid
  • L-1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole-3-carb
  • 2,3,4,9-Tetrahydro-1H-β-carboline-3-carboxylic acid
  • (3S)-1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid
  • (3S)-1,2,3,4-Tetrahydro-β-carboline-3α-carboxylic acid
  • (3S)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3α-carboxylic acid
  • (S)-1,2,3,4-Tetrahydro-β-carboline-3-carboxylic acid
  • (3S)-1H,2H,3H,4H,9H-pyrido[3,4-b]indole-3-carboxylic acid
  • TNCA
  • 4-b]indole-3-carboxylic acid
  • 4-Tetrahydro-9H-pyrido[3
  • 4-Tetrahydro-b-carboline-3-carboxylic acid
  • 9-Tetrahydro-1H-beta-carboline-3-carboxylic acid
  • L -CarL
  • Lycoperodine 1
  • (3S)-2,3,4,9-Tetrahydro-1H-beta-carboline-3-carboxylic acid
  • L-1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid, L-Tryptoline-3-carboxylic acid, H-Tpi-OH, L-1,2,3,4-Tetrahydro-b-carboline-3-carboxylic acid
  • (3S)-1,3,4,9-tetrahydro-$b-carbolin-2-ium-3-carboxylate
  • (3S)-1,3,4,9-tetrahydropyrido[5,4-b]indol-2-ium-3-carboxylate
  • (3S)-2,3,4,9-tetrahydro-1H-$b-carboline-3-carboxylic acid
  • (3S)-2,3,4,9-tetrahydro-1H-pyrido[5,4-b]indole-3-carboxylic acid
  • CYCLOMETHYLTRYPTOPHAN
  • TCR
  • (S)-1,2,3,4-Tetrahydronorharmane-3-carboxylic acid
  • 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2,3,4,9-tetrahydro-, (3S)-
  • L-1,2,3,4-Tetrahydro-β-carbolin-3-carboxylic acid
  • TNCA >=98% (HPLC)
  • Tryptophan Impurity M
  • 42438-90-4
  • 2438-90-4
  • C12H12NO2
  • Phenylalanine analogs and other aromatic alpha amino acids