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Ramosetron hydrochloride

Product Name
Ramosetron hydrochloride
CAS No.
132907-72-3
Chemical Name
Ramosetron hydrochloride
Synonyms
ym060;Nasea OD;(R)-YM-060;RAMOSETRON HCL;YM-060;YM060;YM 060;(r)-monohydrochlorid;Ramosetron Hydrochlorid;Ramosetron hydrocloride;RAMOSETRON HYDROCHLORIDE;Ramosetron hydrochloride (API)
CBNumber
CB1397525
Molecular Formula
C17H18ClN3O
Formula Weight
315.8
MOL File
132907-72-3.mol
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Ramosetron hydrochloride Property

Melting point:
244-246°C
alpha 
D -42.9° (c 1.02 in methanol)
storage temp. 
-20°C
solubility 
H2O: soluble20mg/mL, clear
form 
powder
color 
white to beige
optical activity
[α]/D -40 to -45°, c = 1 in methanol
Stability:
Hygroscopic
InChIKey
XIXYTCLDXQRHJO-RFVHGSKJSA-N
CAS DataBase Reference
132907-72-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
Toxicity
dog,LD,intravenous,> 30mg/kg (30mg/kg),SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE,Oyo Yakuri. Pharmacometrics. Vol. 47, Pg. 117, 1994.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0674
Product name
Ramosetron hydrochloride
Purity
≥98% (HPLC)
Packaging
10mg
Price
$91.6
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0674
Product name
Ramosetron hydrochloride
Purity
≥98% (HPLC)
Packaging
50mg
Price
$354
Updated
2024/03/01
Cayman Chemical
Product number
15548
Product name
Ramosetron (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
15548
Product name
Ramosetron (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$152
Updated
2024/03/01
Cayman Chemical
Product number
15548
Product name
Ramosetron (hydrochloride)
Purity
≥98%
Packaging
50mg
Price
$286
Updated
2024/03/01
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Ramosetron hydrochloride Chemical Properties,Usage,Production

Description

Ramosetron Hydrochloride is the only currently available drug indicated for the treatment of male patients with IBS-D in Japan. Ramosetron Hydrochloride was approved in July 1996 under a brand name of Nasea Injection 0.3 mg and in June 1998 under a brand name of Nasea OD tablets 0.1 mg for the treatment of gastrointestinal symptoms (nausea and vomiting) associated with therapy with antineoplastic drugs (e.g., cisplatin).
Nasea was launched in Japan for chemotherapy-induced emesis. Nasea was prepared by a four step sequence via the Vilsmeier-type coupling of 1-methylindole and 5-( 1- pyrrolidoncarbonyl)-4,5,6,7-tetrahydro-Hl-benzimidazole hydrochloride. The antiemetic activity arises because it is a potent 5-HT3 receptor antagonist that is i.v. and orally active. The (R)-isomer was found to be 100 times more potent than the (S)-isomer. It was able to inhibit cisplatin-induce emesis and was 8670 times more potent than netoclopramide.

Chemical Properties

White Solid

Originator

Yamanouchi (Japan)

Uses

Ramosetron Hydrochloride is a selective serotonin 5-HT3 receptor antagonist and has structurally different from Ondansetron (O655000), Granisetron (G780000). It controls excessive bowel movement and diarrhea by inhibiting 5-HT3 receptors in the intestinal tract. Ramosetron Hydrochloride was approved as film-coated tablets in July 2008 and as orally disintegrating tablets in August 2013 for the indication of treatment of male patients with diarrhea-predominant irritable bowel syndrome.

Definition

ChEBI: Ramosetron hydrochloride is a member of indoles.

brand name

Nasea

Biochem/physiol Actions

Ramosetron is a tetra hydrobenzimidazole derivative, containing an indole ring. It inhibits colon contraction mediated by serotonin, competitively. this pharmacologic property confers the drug an application in improving diarrhea-predominant inflammatory bowel syndrome. Ramosetron hydrochloride is used for PONV prophylaxis and treatment. However, ramosetron is currently only licenced for use in Japan and selected Southeast Asian countries.

Ramosetron hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Ramosetron hydrochloride Suppliers

Canada 1 China 213 Europe 2 Germany 1 India 5 South Korea 1 United Kingdom 9 United States 26 Global 258
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View Lastest Price from Ramosetron hydrochloride manufacturers

Hebei Ganmiao New material Technology Co., LTD
Product
Ramosetron hydrochloride 132907-72-3
Price
US $10.00-8.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-06-07
Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
Ramosetron hydrochloride 132907-72-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2024-04-18
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Ramosetron hydrochloride 132907-72-3
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-12-18

132907-72-3, Ramosetron hydrochloride Related Search:

Topotecan hydrochloride RAMOSETRON Indole-3-butyric acid 1-AdaMantanethylaMine Indometacin Benzimidazole Indole-3-acetic acid 3-(1-methyl-1H-indole-3-carbonyl)hexanedioic acid (3R)-2,3-Dihydro-3-(2-propyn-1-ylaMino)-1H-inden-1-one 1-Methyl-1H-indole-3-carboxylic acid 1-Methylindole Rasagiline Impurity 5 Mesylate 5-(1-methyl-1H-indole-3-carbonyl)-1H-benzo[d]imidazol-2(3H)-one ramosetron 4,5,6,7-Tetrahydro-1H-benzoiMidazole-5-carboxylic acid hydrochloride Rasagiline Impurity 3 3a,7a-dihydroxy-5-(1-methyl-1H-indole-3-carbonyl)-hexahydro-1H-benzo[d]imidazol-2(3H)-one Ramosetron Impurity 13

  • Methanone,(1-Methyl-1H-indol-3-yl)[(6R)-4,5,6,7-tetrahydro-1H-benziMidazol-6-yl]-,hydrochloride (1:1)
  • (R)-5-[(1-Methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahydro-1H-benzimidazole hydrochloride
  • (1-methylindol-3-yl)-[(5r)-4,5,6,7-tetrahydro-3h-benzimidazol-5-yl]methanone hydrochloride
  • RAMOSETRON HCL
  • RAMOSETRON HYDROCHLORIDE
  • (1-methyl-1h-indol-3-yl)(4,5,6,7-tetrahydro-1h-benzimidazol-5-yl)-methanon
  • (r)-5-((1-methyl-3-indolyl)carbonyl)-4,5,6,7-tetrahydro-1h-benzimidazolehydr
  • (r)-monohydrochlorid
  • ym060
  • RAMOSETRON HYDROCHLORIDE 98.5% MIN
  • (1-methyl-3-indolyl)-(4,5,6,7-tetrahydro-3H-benzimidazol-5-yl)methanone hydrochloride
  • (-)-5-(R)-[(1-methylindole-3-yl)carbonyl]-4,5,6,7-tetrahydrobenzimidazole hydrochloride
  • Ramosetron Hydrochlorid
  • Methanone, (1-methyl-1H-indol-3-yl)(4,5,6,7-tetrahydro-1H-benzimidazol-5-yl)-, monohydrochloride, (R)-
  • Methanone, (1-methyl-1H-indol-3-yl)[(5R)-4,5,6,7-tetrahydro-1H-benzimidazol-5-yl]-, monohydrochloride (9CI)
  • (R)-YM-060
  • Nasea OD
  • (1-METHYL-1H-INDOL-3-YL)[(5R)-4,5,6,7-TETRAHYDRO-1H-BENZIMIDAZOL-5-YL]METHANONE
  • Ramosetron hydrocloride
  • (R)-(1-Methyl-1H-indol-3-yl)(4,5,6,7-tetrahydro-1H-benzo[d]iMidazol-6-yl)Methanone hydrochloride
  • (1-Methyl-1H-indol-3-yl)[(6R)-4,5,6,7-tetrahydro-1H-benziMidazol-6-yl]Methanone
  • YM-060;YM060;YM 060
  • Ramosetron HydrochlorideQ: What is Ramosetron Hydrochloride Q: What is the CAS Number of Ramosetron Hydrochloride Q: What is the storage condition of Ramosetron Hydrochloride Q: What are the applications of Ramosetron Hydrochloride
  • Ramosetron hydrochloride (API)
  • 132907-72-3
  • C17H17N3OHCl
  • C17H17N3OClH
  • API
  • Antiemetic
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • 132907-72-3