Ramosetron hydrochloride

ChemicalBook > CAS DataBase List > Ramosetron hydrochloride

Ramosetron hydrochloride

Product Name: Ramosetron hydrochloride
CAS No.: 132907-72-3
Chemical Name: Ramosetron hydrochloride
Synonyms: ym060;Nasea OD;(R)-YM-060;RAMOSETRON HCL;YM-060;YM060;YM 060;(r)-monohydrochlorid;Ramosetron Hydrochlorid;Ramosetron hydrocloride;RAMOSETRON HYDROCHLORIDE;Ramosetron hydrochloride (API)
CBNumber: CB1397525
Molecular Formula: C17H18ClN3O
Formula Weight: 315.8
MOL File: 132907-72-3.mol

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Ramosetron hydrochloride Property

Melting point:: 244-246°C
alpha: D -42.9° (c 1.02 in methanol)
storage temp.: -20°C
solubility: H2O: soluble20mg/mL, clear
form: powder
color: white to beige
optical activity: [α]/D -40 to -45°, c = 1 in methanol
Stability:: Hygroscopic
InChIKey: XIXYTCLDXQRHJO-RFVHGSKJSA-N
CAS DataBase Reference: 132907-72-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
Toxicity: dog,LD,intravenous,> 30mg/kg (30mg/kg),SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE,Oyo Yakuri. Pharmacometrics. Vol. 47, Pg. 117, 1994.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0674
Product name: Ramosetron hydrochloride
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $91.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0674
Product name: Ramosetron hydrochloride
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $354
Updated: 2024/03/01

Cayman Chemical

Product number: 15548
Product name: Ramosetron (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 15548
Product name: Ramosetron (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $152
Updated: 2024/03/01

Cayman Chemical

Product number: 15548
Product name: Ramosetron (hydrochloride)
Purity: ≥98%
Packaging: 50mg
Price: $286
Updated: 2024/03/01

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Ramosetron hydrochloride Chemical Properties,Usage,Production

Description

Ramosetron Hydrochloride is the only currently available drug indicated for the treatment of male patients with IBS-D in Japan. Ramosetron Hydrochloride was approved in July 1996 under a brand name of Nasea Injection 0.3 mg and in June 1998 under a brand name of Nasea OD tablets 0.1 mg for the treatment of gastrointestinal symptoms (nausea and vomiting) associated with therapy with antineoplastic drugs (e.g., cisplatin).
Nasea was launched in Japan for chemotherapy-induced emesis. Nasea was prepared by a four step sequence via the Vilsmeier-type coupling of 1-methylindole and 5-( 1- pyrrolidoncarbonyl)-4,5,6,7-tetrahydro-Hl-benzimidazole hydrochloride. The antiemetic activity arises because it is a potent 5-HT3 receptor antagonist that is i.v. and orally active. The (R)-isomer was found to be 100 times more potent than the (S)-isomer. It was able to inhibit cisplatin-induce emesis and was 8670 times more potent than netoclopramide.

Chemical Properties

White Solid

Originator

Yamanouchi (Japan)

Uses

Ramosetron Hydrochloride is a selective serotonin 5-HT3 receptor antagonist and has structurally different from Ondansetron (O655000), Granisetron (G780000). It controls excessive bowel movement and diarrhea by inhibiting 5-HT3 receptors in the intestinal tract. Ramosetron Hydrochloride was approved as film-coated tablets in July 2008 and as orally disintegrating tablets in August 2013 for the indication of treatment of male patients with diarrhea-predominant irritable bowel syndrome.

Definition

ChEBI: Ramosetron hydrochloride is a member of indoles.

brand name

Nasea

Biochem/physiol Actions

Ramosetron is a tetra hydrobenzimidazole derivative, containing an indole ring. It inhibits colon contraction mediated by serotonin, competitively. this pharmacologic property confers the drug an application in improving diarrhea-predominant inflammatory bowel syndrome. Ramosetron hydrochloride is used for PONV prophylaxis and treatment. However, ramosetron is currently only licenced for use in Japan and selected Southeast Asian countries.

Ramosetron hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ramosetron hydrochloride manufacturers

Hebei Ganmiao New material Technology Co., LTD

Product: Ramosetron hydrochloride 132907-72-3
Price: US $10.00-8.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-06-07

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Ramosetron hydrochloride 132907-72-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20tons
Release date: 2024-04-18

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

Product: Ramosetron hydrochloride 132907-72-3
Price: US $0.00/KG
Min. Order: 100g
Purity: 98%+
Supply Ability: 100kg
Release date: 2020-12-18

132907-72-3, Ramosetron hydrochloride Related Search:

Topotecan hydrochloride RAMOSETRON Indole-3-butyric acid 1-AdaMantanethylaMine Indometacin Benzimidazole Indole-3-acetic acid 3-(1-methyl-1H-indole-3-carbonyl)hexanedioic acid (3R)-2,3-Dihydro-3-(2-propyn-1-ylaMino)-1H-inden-1-one 1-Methyl-1H-indole-3-carboxylic acid 1-Methylindole Rasagiline Impurity 5 Mesylate 5-(1-methyl-1H-indole-3-carbonyl)-1H-benzo[d]imidazol-2(3H)-one ramosetron 4,5,6,7-Tetrahydro-1H-benzoiMidazole-5-carboxylic acid hydrochloride Rasagiline Impurity 3 3a,7a-dihydroxy-5-(1-methyl-1H-indole-3-carbonyl)-hexahydro-1H-benzo[d]imidazol-2(3H)-one Ramosetron Impurity 13

Methanone,(1-Methyl-1H-indol-3-yl)[(6R)-4,5,6,7-tetrahydro-1H-benziMidazol-6-yl]-,hydrochloride (1:1)

(R)-5-[(1-Methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahydro-1H-benzimidazole hydrochloride

(1-methylindol-3-yl)-[(5r)-4,5,6,7-tetrahydro-3h-benzimidazol-5-yl]methanone hydrochloride

RAMOSETRON HCL

RAMOSETRON HYDROCHLORIDE

(1-methyl-1h-indol-3-yl)(4,5,6,7-tetrahydro-1h-benzimidazol-5-yl)-methanon

(r)-5-((1-methyl-3-indolyl)carbonyl)-4,5,6,7-tetrahydro-1h-benzimidazolehydr

(r)-monohydrochlorid

ym060

RAMOSETRON HYDROCHLORIDE 98.5% MIN

(1-methyl-3-indolyl)-(4,5,6,7-tetrahydro-3H-benzimidazol-5-yl)methanone hydrochloride

(-)-5-(R)-[(1-methylindole-3-yl)carbonyl]-4,5,6,7-tetrahydrobenzimidazole hydrochloride

Ramosetron Hydrochlorid

Methanone, (1-methyl-1H-indol-3-yl)(4,5,6,7-tetrahydro-1H-benzimidazol-5-yl)-, monohydrochloride, (R)-

Methanone, (1-methyl-1H-indol-3-yl)[(5R)-4,5,6,7-tetrahydro-1H-benzimidazol-5-yl]-, monohydrochloride (9CI)

(R)-YM-060

Nasea OD

(1-METHYL-1H-INDOL-3-YL)[(5R)-4,5,6,7-TETRAHYDRO-1H-BENZIMIDAZOL-5-YL]METHANONE

Ramosetron hydrocloride

(R)-(1-Methyl-1H-indol-3-yl)(4,5,6,7-tetrahydro-1H-benzo[d]iMidazol-6-yl)Methanone hydrochloride

(1-Methyl-1H-indol-3-yl)[(6R)-4,5,6,7-tetrahydro-1H-benziMidazol-6-yl]Methanone

YM-060;YM060;YM 060

Ramosetron HydrochlorideQ: What is Ramosetron Hydrochloride Q: What is the CAS Number of Ramosetron Hydrochloride Q: What is the storage condition of Ramosetron Hydrochloride Q: What are the applications of Ramosetron Hydrochloride

Ramosetron hydrochloride (API)

132907-72-3

C17H17N3OHCl

C17H17N3OClH

API

Antiemetic

Chiral Reagents

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

132907-72-3