2,6-DIBROMOANISOLE
- Product Name
- 2,6-DIBROMOANISOLE
- CAS No.
- 38603-09-7
- Chemical Name
- 2,6-DIBROMOANISOLE
- Synonyms
- 2,6-DIBROMOANISOLE;2,6-Dibromoanisole,>97%;2,6-Dibromo-1-methoxybenzene;1,3-Dibromo-2-methoxybenzene;Benzene,1,3-dibroMo-2-Methoxy-
- CBNumber
- CB1397570
- Molecular Formula
- C7H6Br2O
- Formula Weight
- 265.93
- MOL File
- 38603-09-7.mol
2,6-DIBROMOANISOLE Property
- Melting point:
- 13°C
- Boiling point:
- 254℃
- Density
- 1.823
- refractive index
- 1.5920 to 1.5960
- Flash point:
- 100℃
- storage temp.
- Sealed in dry,Room Temperature
- form
- clear liquid
- color
- Colorless to Light yellow
- InChI
- InChI=1S/C7H6Br2O/c1-10-7-5(8)3-2-4-6(7)9/h2-4H,1H3
- InChIKey
- BMZVDHQOAJUZJL-UHFFFAOYSA-N
- SMILES
- C1(Br)=CC=CC(Br)=C1OC
- CAS DataBase Reference
- 38603-09-7
Safety
- HS Code
- 2909303840
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D5279
- Product name
- 2,6-Dibromoanisole
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $76
- Updated
- 2025/07/31
- Product number
- D5279
- Product name
- 2,6-Dibromoanisole
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $227
- Updated
- 2025/07/31
- Product number
- D422975
- Product name
- 2,6-Dibromoanisole
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- D422975
- Product name
- 2,6-Dibromoanisole
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FD142831
- Product name
- 1,3-Dibromo-2-methoxybenzene
- Packaging
- 250mg
- Price
- $62.5
- Updated
- 2021/12/16
2,6-DIBROMOANISOLE Chemical Properties,Usage,Production
Uses
2,6-Dibromoanisole is an anisole compound containing a substituent bromine atom that can be used in bromine substitution reactions to prepare other organic ether derivatives. It is also a Lusutrombopag intermediate, which is used to treat thrombocytopenia (low platelets in the blood) in adult patients with chronic liver disease who are scheduled to undergo medical or dental procedures.
Synthesis
608-33-3
74-88-4
38603-09-7
Example 1 Preparation of 2,6-dibromo-4-(6-(3-bromobenzyloxy)pyridazin-3-yl)phenol (Compound 91): to a stirred solution of 2,6-dibromophenol (5.26 g, 20.9 mmol) in acetone (170 mL) was added anhydrous potassium carbonate (4.33 g, 31.3 mmol) and the mixture was stirred at room temperature for 30 minutes. Iodomethane (1.97 mL, 31.4 mmol) was then added and the reaction mixture was heated to reflux at 60 °C for 3 hours. After completion of the reaction, the mixture was filtered and the filtrate was concentrated by rotary evaporation. The residue was extracted by partitioning between petroleum ether (40-60 °C, 100 mL) and water (100 mL). The aqueous layer was extracted once more with petroleum ether (40-60 °C, 100 mL), and the organic phases were combined, washed with brine (50 mL), dried over anhydrous magnesium sulfate, filtered, and concentrated to afford 5.43 g (98% yield) of the target compound, 1 ,3-dibromo-2-methoxybenzene, as a colorless oil.1H NMR (CDCl3, δ ppm): 3.89 (3H, s), 6.86 (1H, t, J = 8.02 Hz), 7.50 (2H, d, J = 8.01 Hz).
References
[1] Tetrahedron Letters, 2008, vol. 49, # 33, p. 4912 - 4914
[2] Patent: US2009/270398, 2009, A1. Location in patent: Page/Page column 35
[3] Journal of the American Chemical Society, 2009, vol. 131, # 47, p. 17371 - 17375
[4] Journal of the American Chemical Society, 2016, vol. 138, # 31, p. 9779 - 9782
[5] Patent: WO2009/103440, 2009, A1. Location in patent: Page/Page column 75
2,6-DIBROMOANISOLE Preparation Products And Raw materials
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View Lastest Price from 2,6-DIBROMOANISOLE manufacturers
- Product
- 2,6-DIBROMOANISOLE 38603-09-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-24