ChemicalBook > CAS DataBase List > Cinobufotalin

Cinobufotalin

Product Name: Cinobufotalin
CAS No.: 1108-68-5
Chemical Name: Cinobufotalin
Synonyms: Nsc90326;Cinobufotlin;CINOBUFOTALIN;Chinbufotalin;CINOBUFOTALIN(RG);Cinobufotalin std.;Cinobufotalin Standard;Cinobufotalin USP/EP/BP;cinobufotalin venom toad;5beta-Hydroxycinobufagin
CBNumber: CB1410581
Molecular Formula: C26H34O7
Formula Weight: 458.54
MOL File: 1108-68-5.mol

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Cinobufotalin Property

Melting point:: 259-262°
alpha: D20 +11°
Boiling point:: 627.3±55.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 5 mg/ml; Ethanol: 5 mg/ml
pka: 14.67±0.70(Predicted)
form: White to off-white solid.
color: White to off-white
InChIKey: KBKUJJFDSHBPPA-XYCOMLSLNA-N
SMILES: [C@]123O[C@@H]1[C@@H]([C@H](C1=COC(=O)C=C1)[C@@]2(C)CC[C@]1([H])[C@@]2(C)CC[C@H](O)C[C@@]2(O)CC[C@@]31[H])OC(=O)C |&1:0,2,3,4,12,16,18,22,25,29,r|
CAS DataBase Reference: 1108-68-5

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Safety

Hazard Codes: T+
Risk Statements: 26/27/28
Safety Statements: 22-36/37/39-45
RIDADR: UN 2811 6.1/PG 1
WGK Germany: 3
RTECS: EI2991000
HazardClass: 6.1(a)
PackingGroup: II
Toxicity: cat,LD50,intravenous,200ug/kg (0.2mg/kg),"Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963Vol. -, Pg. 189, 1963.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C1147
Product name: Cinobufotalin
Packaging: 10mg
Price: $416
Updated: 2024/03/01

Cayman Chemical

Product number: 19845
Product name: Cinobufotalin
Packaging: 5mg
Price: $112
Updated: 2024/03/01

Cayman Chemical

Product number: 19845
Product name: Cinobufotalin
Packaging: 25mg
Price: $341
Updated: 2024/03/01

Cayman Chemical

Product number: 19845
Product name: Cinobufotalin
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 19845
Product name: Cinobufotalin
Packaging: 10mg
Price: $172
Updated: 2024/03/01

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Cinobufotalin Chemical Properties,Usage,Production

Description

Cinobufacin is an indole-type total alkaloid extracted from the dried toad skin of Chinese toad, which has the functions of clearing away heat and detoxifying, reducing swelling and pain, promoting blood circulation and removing blood stasis, softening and dispelling knots.

Uses

Cinobufotalin is a cardiotonic steroids or bufadienolides, is extracted from the skin secretions of the giant toads. Cinobufotalin has been used as a cardiotonic, diuretic and a hemostatic agent, Cinobufotalin is also a potential anti-lung cancer agent[1].

Application

Cinobufacin can be used for a variety of middle and advanced tumors (lung cancer, breast cancer, cervical cancer, digestive system tumors such as primary liver cancer, gastric cancer, colon cancer, etc.), chronic hepatitis B, especially for chronic hepatitis B virus carriers. Especially prominent.

Side effects

For individual patients, if the dosage is too large or the interval between two administrations is less than 6 to 8 hours, chills and fever may occur about 30 minutes after administration; a small number of patients have local irritation or phlebitis after long-term intravenous infusion, which will slow down the infusion rate. Very few patients may also appear urticaria, dermatitis and so on.

in vivo

Cinobufotalin (1-5 mg/kg; intraperitoneal injection; twice daily; for 1 weeks; male nude mice) treatment inhibits A549 lung cancer cell growth in vivo^[1].

Animal Model:	Male nude mice (4-6 weeks old, BALB/c) with A549 cells^[1]
Dosage:	1 mg/kg or 5 mg/kg
Administration:	Intraperitoneal injection; twice daily; for 1 weeks
Result:	Inhibited A549 lung cancer cell growth in vivo.

References

[1] Kai S, et al. Pre-clinical evaluation of cinobufotalin as a potential anti-lung cancer agent. Biochem Biophys Res Commun. 2014 Sep 26;452(3):768-74. DOI:10.1016/j.bbrc.2014.08.147
[2] Li C, Guo H, Wang C, et al. Network pharmacological mechanism of Cinobufotalin against glioma. Prog Brain Res. 2021;265:119-137. DOI:10.1016/bs.pbr.2021.06.001

Cinobufotalin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Cinobufotalin manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Cinobufotalin 1108-68-5
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-03-20

Dideu Industries Group Limited

Product: Cinobufotalin 1108-68-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-02

Shaanxi Dideu Medichem Co. Ltd

Product: Cinobufotalin 1108-68-5
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 800 ton
Release date: 2020-04-30

1108-68-5, CinobufotalinRelated Search:

Ethyl acetate Sodium acetate Vinyl acetate Methyl acetate Glatiramer acetate Butyl acetate Potassium Acetate Tocopheryl acetate ACETATE bufoin injection ALPHA-PYRONE 1,2-EPOXYTETRADECANE (R)-(+)-1,2-Epoxybutane 1,2-Epoxydodecane TERPIN MONOHYDRATE 2,3-EPOXY-2-METHYLBUTANE CIS-1,2-CYCLOPENTANEDIOL (R)-(+)-Glycidol

cinobufotalin venom toad

Cinobufotalin std.

5BETA,20[22]-BUFADIENOLIDE-14,15BETA-EPOXY-3BETA,5ALPHA,16BETA-TRIOL 16-ACETATE

14,15-beta-epoxy-3-beta,5,16-beta-trihydroxy-22-dienolid16-5-beta-bufa-2

CINOBUFOTALIN(RG)

14,15b-Epoxy-3b,5a,16b-trihydroxy-5b,20(22)-bufadienolide 16-acetate

5β,20(22)-Bufadienolide-14,15β-epoxy-3β,5α,16β-triol 16-acetate, 14,15β-Epoxy-3β,5α,16β-trihydroxy-5β,20(22)-bufadienolide 16-acetate

14,15-Epoxy-14H-cyclopenta[a]phenanthrene, bufa-20,22-dienolide deriv.

5-b-Bufa-20,22-dienolide, 14,15-b-epoxy-3-b,5,16-b-trihydroxy, 16-acetate

Bufa-20,22-dienolide, 16- (acetyloxy)-14,15-epoxy-3,5-dihydroxy-, (3.beta.,5.beta.,15.beta.,16.beta.)-

16β-(Acetyloxy)-14,15β-epoxy-3β,5-dihydroxy-5β,14β-bufa-20,22-dienolide

16β-Acetoxy-14,15β-epoxy-3β,5-dihydroxy-5β-bufa-20,22-dienolide

3β,5β-Dihydroxy-16β-acetoxy-14,15β-epoxy-5β-bufa-20,22-dienolide

5.beta.-Bufa-20,22-dienolide, 14,15.beta.-epoxy-3.beta.,5,16.beta.-trihydroxy-, 16-acetate

Cinobufotlin

Nsc90326

14,15β-Epoxy-3β,5α,16β-trihydroxy-5β,20(22)-bufadienolide 16-acetate

5β,20(22)-Bufadienolide-14,15β-epoxy-3β,5α,16β-triol 16-acetate

CINOBUFOTALIN

20,22,5BETA-BUFADIENOLID-14BETA,15BETA-EPOXY-3BETA, 5BETA, 6BETA-TRIOL-16-ACETATE

Cinobufotalin, 98%, from animal extracts

14,15BETA-EPOXY-3BETA,5ALPHA,16BETA-TRIHYDROXY-5BETA,20[22]-BUFADIENOLIDE 16-ACETATE

5beta-Hydroxycinobufagin, HPLC≥98%

Cinobufotalin Standard

Bufa-20,22-dienolide, 16-(acetyloxy)-14,15-epoxy-3,5-dihydroxy-, (3β,5β,15β,16β)-

Cinobufotalin USP/EP/BP

5beta-Hydroxycinobufagin

Chinbufotalin

(1R,2R,2aR,3aS,3bR,5aS,7S,9aR,9bS,11aR)-5a,7-Dihydroxy-9a,11a-dimethyl-1-(2-oxo-2H-pyran-5-yl)hexadecahydronaphtho[1',2':6,7]indeno[1,7a-b]oxiren-2-yl acetate

Cinobufotalin, 10 mM in DMSO

(1R,2R,2aR,3aS,3bR,5aS,7S,9aR,9bS,11aR)-5a,7-Dihydroxy-9a,11a-dimethyl-1-(2-oxo-2H-pyran-5-yl)hexadecahydronaphtho[1',2':6,7]indeno[1,7a-b]oxiren-2-yl acetate

1108-68-5

C26H34O7