1-(2-Chloroethyl)piperidine hydrochloride
- Product Name
- 1-(2-Chloroethyl)piperidine hydrochloride
- CAS No.
- 2008-75-5
- Chemical Name
- 1-(2-Chloroethyl)piperidine hydrochloride
- Synonyms
- N-(2-CHLOROETHYL)PIPERIDINE HYDROCHLORIDE;PIPEC;1-(2-Chloroethyl)pip;Pramoxine Impurity 12;2-Piperidinoethyl chiloride;2-CHLOROETHYLPIPERIDINE HCL;PIPERIDINO ETHYL CHLORIDE HCL;2-ChloroethylpiperidineHcl98%;Levocloperastine CEP Impurity;N-(2-CHLOROETHYL)PIPERIDINE HCL
- CBNumber
- CB1412444
- Molecular Formula
- C7H15Cl2N
- Formula Weight
- 184.11
- MOL File
- 2008-75-5.mol
1-(2-Chloroethyl)piperidine hydrochloride Property
- Melting point:
- 230-232 °C(lit.)
- Boiling point:
- 196 °C
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- Powder or Crystals
- color
- White to pale yellow to beige
- Water Solubility
- soluble
- Sensitive
- Hygroscopic
- BRN
- 3910268
- InChI
- InChI=1S/C7H14ClN.ClH/c8-4-7-9-5-2-1-3-6-9;/h1-7H2;1H
- InChIKey
- VFLQQZCRHPIGJU-UHFFFAOYSA-N
- SMILES
- N1(CCCl)CCCCC1.Cl
- CAS DataBase Reference
- 2008-75-5(CAS DataBase Reference)
Safety
- Hazard Codes
- T+,Xi
- Risk Statements
- 28-34-36/37/38
- Safety Statements
- 26-28-36/37/39-45-24/25
- RIDADR
- UN 2928 6.1/PG 2
- WGK Germany
- 2
- RTECS
- TM6482500
- HazardClass
- 6.1
- PackingGroup
- II
- HS Code
- 29333999
- Toxicity
- mouse,LD50,intraperitoneal,93mg/kg (93mg/kg),BEHAVIORAL: ATAXIA,Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 249, 1948.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C42602
- Product name
- 1-(2-Chloroethyl)piperidine hydrochloride
- Purity
- 98%
- Packaging
- 100g
- Price
- $72.2
- Updated
- 2025/07/31
- Product number
- C42602
- Product name
- 1-(2-Chloroethyl)piperidine hydrochloride
- Purity
- 98%
- Packaging
- 500g
- Price
- $203
- Updated
- 2022/05/15
- Product number
- C1073
- Product name
- 1-(2-Chloroethyl)piperidine Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $65
- Updated
- 2025/07/31
- Product number
- C1073
- Product name
- 1-(2-Chloroethyl)piperidine Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 500g
- Price
- $457
- Updated
- 2025/07/31
- Product number
- C366745
- Product name
- N-(β-Chloroethyl)piperidineHydrochloride
- Packaging
- 100g
- Price
- $165
- Updated
- 2021/12/16
1-(2-Chloroethyl)piperidine hydrochloride Chemical Properties,Usage,Production
Chemical Properties
Colorless to beige crystals
Uses
Hydrochloride salt of N-(β-Chloroethyl)piperidine is used in the inhibition of sickle-cell hemoglobin.
Uses
1-(2-Chloroethyl)piperidine hydrochloride is used as intermediate for the syntheses of pharmaceuticals (e.g. fenpiverinium bromide, cloperastine and pitofenone).
Synthesis
3040-44-6
2008-75-5
The general procedure for the synthesis of 1-(2-chloroethyl)piperidine hydrochloride using N-hydroxyethylpiperidine as starting material was as follows: N-hydroxyethylpiperidine (5 mL) was dissolved in chloroform (12.5 mL). Thionyl chloride (3.4 mL) was added slowly and dropwise under ice bath cooling conditions. The reaction mixture was slowly heated to reflux and the reflux reaction was maintained for 3 hours. Upon completion of the reaction, it was cooled to room temperature and the solvent was removed by distillation under reduced pressure to give a large crystalline precipitate. Finally, the product was purified by ethanol recrystallization to give 5.88 g of 1-(2-chloroethyl)piperidine hydrochloride in 85% yield.
References
[1] Patent: CN105884699, 2016, A. Location in patent: Paragraph 0048; 0049
[2] Patent: US2006/223855, 2006, A1. Location in patent: Page/Page column 160-161
[3] Journal of Polymer Science, Part A: Polymer Chemistry, 2014, vol. 52, # 5, p. 671 - 679
1-(2-Chloroethyl)piperidine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
1-(2-Chloroethyl)piperidine hydrochloride Suppliers
- Tel
- 13708085536 13708085536
- Fax
- QQ : 121102042
- hanovichem@163.com
- Country
- China
- ProdList
- 3282
- Advantage
- 56
- Tel
- 0574-87365517 18074210286
- Fax
- 87367735
- sales@taikangchem.com
- Country
- China
- ProdList
- 294
- Advantage
- 58
- Tel
- 0838-5675166 15883665058
- Fax
- 0838-5675535
- nbcxkj@126.com
- Country
- China
- ProdList
- 918
- Advantage
- 55
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 400-0066400 13621662912
- Fax
- 021-55660885
- sales@jonln.com
- Country
- China
- ProdList
- 1995
- Advantage
- 65
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 0311-89250318 031166536426
- Fax
- 4000311741
- master@sjzsdyn.com
- Country
- China
- ProdList
- 2807
- Advantage
- 65
View Lastest Price from 1-(2-Chloroethyl)piperidine hydrochloride manufacturers
- Product
- 2-Piperidinoethylchloride hydrochloride 2008-75-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2018-08-21