ChemicalBook > CAS DataBase List > 1-(2-Chloroethyl)piperidine hydrochloride

1-(2-Chloroethyl)piperidine hydrochloride

Product Name
1-(2-Chloroethyl)piperidine hydrochloride
CAS No.
2008-75-5
Chemical Name
1-(2-Chloroethyl)piperidine hydrochloride
Synonyms
N-(2-CHLOROETHYL)PIPERIDINE HYDROCHLORIDE;PIPEC;1-(2-Chloroethyl)pip;Pramoxine Impurity 12;2-Piperidinoethyl chiloride;2-CHLOROETHYLPIPERIDINE HCL;PIPERIDINO ETHYL CHLORIDE HCL;2-ChloroethylpiperidineHcl98%;Levocloperastine CEP Impurity;N-(2-CHLOROETHYL)PIPERIDINE HCL
CBNumber
CB1412444
Molecular Formula
C7H15Cl2N
Formula Weight
184.11
MOL File
2008-75-5.mol
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1-(2-Chloroethyl)piperidine hydrochloride Property

Melting point:
230-232 °C(lit.)
Boiling point:
196 °C
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
Powder or Crystals
color 
White to pale yellow to beige
Water Solubility 
soluble
Sensitive 
Hygroscopic
BRN 
3910268
InChI
InChI=1S/C7H14ClN.ClH/c8-4-7-9-5-2-1-3-6-9;/h1-7H2;1H
InChIKey
VFLQQZCRHPIGJU-UHFFFAOYSA-N
SMILES
N1(CCCl)CCCCC1.Cl
CAS DataBase Reference
2008-75-5(CAS DataBase Reference)
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Safety

Hazard Codes 
T+,Xi
Risk Statements 
28-34-36/37/38
Safety Statements 
26-28-36/37/39-45-24/25
RIDADR 
UN 2928 6.1/PG 2
WGK Germany 
2
RTECS 
TM6482500
HazardClass 
6.1
PackingGroup 
II
HS Code 
29333999
Toxicity
mouse,LD50,intraperitoneal,93mg/kg (93mg/kg),BEHAVIORAL: ATAXIA,Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 249, 1948.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C42602
Product name
1-(2-Chloroethyl)piperidine hydrochloride
Purity
98%
Packaging
100g
Price
$72.2
Updated
2025/07/31
Sigma-Aldrich
Product number
C42602
Product name
1-(2-Chloroethyl)piperidine hydrochloride
Purity
98%
Packaging
500g
Price
$203
Updated
2022/05/15
TCI Chemical
Product number
C1073
Product name
1-(2-Chloroethyl)piperidine Hydrochloride
Purity
>98.0%(T)
Packaging
25g
Price
$65
Updated
2025/07/31
TCI Chemical
Product number
C1073
Product name
1-(2-Chloroethyl)piperidine Hydrochloride
Purity
>98.0%(T)
Packaging
500g
Price
$457
Updated
2025/07/31
TRC
Product number
C366745
Product name
N-(β-Chloroethyl)piperidineHydrochloride
Packaging
100g
Price
$165
Updated
2021/12/16
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1-(2-Chloroethyl)piperidine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Colorless to beige crystals

Uses

Hydrochloride salt of N-(β-Chloroethyl)piperidine is used in the inhibition of sickle-cell hemoglobin.

Uses

1-(2-Chloroethyl)piperidine hydrochloride is used as intermediate for the syntheses of pharmaceuticals (e.g. fenpiverinium bromide, cloperastine and pitofenone).

Synthesis

3040-44-6

2008-75-5

The general procedure for the synthesis of 1-(2-chloroethyl)piperidine hydrochloride using N-hydroxyethylpiperidine as starting material was as follows: N-hydroxyethylpiperidine (5 mL) was dissolved in chloroform (12.5 mL). Thionyl chloride (3.4 mL) was added slowly and dropwise under ice bath cooling conditions. The reaction mixture was slowly heated to reflux and the reflux reaction was maintained for 3 hours. Upon completion of the reaction, it was cooled to room temperature and the solvent was removed by distillation under reduced pressure to give a large crystalline precipitate. Finally, the product was purified by ethanol recrystallization to give 5.88 g of 1-(2-chloroethyl)piperidine hydrochloride in 85% yield.

References

[1] Patent: CN105884699, 2016, A. Location in patent: Paragraph 0048; 0049
[2] Patent: US2006/223855, 2006, A1. Location in patent: Page/Page column 160-161
[3] Journal of Polymer Science, Part A: Polymer Chemistry, 2014, vol. 52, # 5, p. 671 - 679

1-(2-Chloroethyl)piperidine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(2-Chloroethyl)piperidine hydrochloride Suppliers

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View Lastest Price from 1-(2-Chloroethyl)piperidine hydrochloride manufacturers

Career Henan Chemical Co
Product
2-Piperidinoethylchloride hydrochloride 2008-75-5
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2018-08-21

2008-75-5, 1-(2-Chloroethyl)piperidine hydrochlorideRelated Search:

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