11-KETO-BETA-BOSWELLIC ACID

ChemicalBook > CAS DataBase List > 11-KETO-BETA-BOSWELLIC ACID

11-KETO-BETA-BOSWELLIC ACID

Product Name: 11-KETO-BETA-BOSWELLIC ACID
CAS No.: 17019-92-0
Chemical Name: 11-KETO-BETA-BOSWELLIC ACID
Synonyms: Pharoxifene;Raloxifenum;11-Oxo-β-boswellic Acid;11-Oxo-β-boswellic acid;β-Boswellic acid,11-keto;11-keto-β-Boswellic Acid;β-Boswellic acid,11-keto;Boswellic Acid Impurity 2;11-KETO-BETA-BOSWELLIC ACID;Beta-boswellic acid,11-keto
CBNumber: CB1415526
Molecular Formula: C30H46O4
Formula Weight: 470.68
MOL File: 17019-92-0.mol

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11-KETO-BETA-BOSWELLIC ACID Property

Melting point:: 190～192℃
Boiling point:: 591.8±50.0 °C(Predicted)
Density: 1.14±0.1 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: ≤5mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide
pka: 4.46±0.70(Predicted)
form: Solid
color: White
Water Solubility: insoluble in water
InChIKey: YIMHGPSYDOGBPI-IQQSWPBXSA-N
LogP: 7.100 (est)

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Safety

WGK Germany: 3
HS Code: 29189900

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL89169
Product name: 11-Keto-β-boswellic acid
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $584
Updated: 2024/03/01

Sigma-Aldrich

Product number: 78535
Product name: 11-Keto-β-boswellic acid
Purity: analytical standard
Packaging: 5mg
Price: $561
Updated: 2024/03/01

Cayman Chemical

Product number: 11668
Product name: 11-keto-β-Boswellic Acid
Purity: ≥95%
Packaging: 1mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 11668
Product name: 11-keto-β-Boswellic Acid
Purity: ≥95%
Packaging: 5mg
Price: $412
Updated: 2024/03/01

Cayman Chemical

Product number: 11668
Product name: 11-keto-β-Boswellic Acid
Purity: ≥95%
Packaging: 10mg
Price: $684
Updated: 2024/03/01

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11-KETO-BETA-BOSWELLIC ACID Chemical Properties,Usage,Production

Uses

A constitutent of frankincense (olibanum) with anti-inflammatory properties. It has been shown to trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells.

Biological Activity

37.9 μm: blocks a2780 (cis-platin resistant ovarian cancer cells) [1].11-keto-β-boswellic acid, known as kba, is a naturally occurring pentacyclic triterpene isolated from the gum resin of the tree boswellia serrata. kba is non-redox, specific leukotriene synthesis inhibitors through the inhibition of 5-lipoxygenase (5-lox) which has anti-arthritic and anti-inflammatory activities. 5-lox catalyzes essential fatty acids substrates into leukotrienes and a variety of other biologically active products. kba is a novel activator of nuclear factor erythroid-2-related factor 2 (nrf2), which protects against cerebral ischemic injury.

in vitro

kba, concentration dependently, decreased the formation of leukotriene b4 and the synthesis of all 5-lox products from endogenous arachidonic acid in rat peritoneal neutrophils. in contrast, kba exerted no remarkable effects on the 12-lipoxygenase and cyclooxygenase activities. [2].

in vivo

adult male sprague–dawley rats were injected kab intraperitoneally at a dose of 25 mg/kg for 48 hours. kab remarkably decreased infarct volumes as well as apoptotic cells at 1 h, and then increased neurologic scores when applied 48 h. moreover, posttreatment with kba induced the decrease of malondialdehyde levels and the increase of protein nrf2 and heme oxygenase-1 expression in brain tissues, indicating that the nrf2/ho-1 pathway was involved in the neuroprotection of kba against oxidative stress-induced ischemic injury [3].

IC 50

35.8 μm: inhibits mcf-7 (human breast adenocarcinoma) [1].

References

[1]. csuk, r., barthel-niesen, a., barthel, a., schffer, r., & al-harrasi, a. 11-keto-boswellic acid derived amides and monodesmosidic saponins induce apoptosis in breast and cervical cancers cells. european journal of medicinal chemistry. 2015; 100: 98-105.
[2]. safayhi, h., mack, t. h. o. m. a. s., sabieraj, j. o. a. c. h. i. m., anazodo, m. i., subramanian, l. r., & ammon, h. p. boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase. journal of pharmacology and experimental therapeutics. 1992; 261(3):1143-1146.
[3]. ding, y., chen, m., wang, m., li, y., & wen, a. posttreatment with 11-keto-β-boswellic acid ameliorates cerebral ischemia–reperfusion injury: nrf2/ho-1 pathway as a potential mechanism. molecular neurobiology. 2014; 52(3): 1430-1439.

11-KETO-BETA-BOSWELLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 11-KETO-BETA-BOSWELLIC ACID manufacturers

R&D Scientific Inc.

Product: 11-Keto-beta-boswellic acid 17019-92-0
Price: US $1400.00/mg
Min. Order: 1mg
Purity: 98
Supply Ability: 500 Kg
Release date: 2024-03-31

Career Henan Chemical Co

Product: 11-KETO-BETA-BOSWELLIC ACID 17019-92-0
Price: US $1.00/kg
Min. Order: 1g
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-24

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11-Oxo-β-boswellic acid

Pharoxifene

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17019-92-0

Apoptosis

Heterocycles

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