ChemicalBook > CAS DataBase List > D-Ribose

D-Ribose

Product Name
D-Ribose
CAS No.
50-69-1
Chemical Name
D-Ribose
Synonyms
D-(-)-RIBOSE;(2R,3R,4R)-2,3,4,5-Tetrahydroxypentanal;D-Ribose/D(-)-Ribose;d-ribos;R-RIBOSE;FEMA 3793;RIBOSE, D-(-)-;D-RIB;D-RIBOSE;d-riboRIBOS
CBNumber
CB1418895
Molecular Formula
C5H10O5
Formula Weight
150.13
MOL File
50-69-1.mol
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D-Ribose Property

Melting point:
88-92 °C(lit.)
alpha 
-20.8 º (c=4, H2O)
Boiling point:
191.65°C (rough estimate)
Density 
1.1897 (rough estimate)
refractive index 
-21 ° (C=1, H2O)
FEMA 
3793 | D-RIBOSE
storage temp. 
2-8°C
solubility 
H2O: 0.1 g/mL, clear, colorless to light yellow
pka
12.46±0.20(Predicted)
form 
Crystalline Powder
color 
White to light beige or slightly yellow
PH Range
7
optical activity
[α]21/D 19.7°, c = 4 in H2O
Water Solubility 
Soluble in water. Insoluble in ether.
Sensitive 
Hygroscopic
Merck 
14,8204
BRN 
1723081
InChIKey
HMFHBZSHGGEWLO-SOOFDHNKSA-N
LogP
-1.47
CAS DataBase Reference
50-69-1(CAS DataBase Reference)
NIST Chemistry Reference
D-Ribose(50-69-1)
EPA Substance Registry System
D-Ribose (50-69-1)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/38
Safety Statements 
24/25-37/39-26
WGK Germany 
3
RTECS 
VJ2275000
F 
3-10
TSCA 
Yes
HS Code 
29400090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
W379312
Product name
D-Ribose
Purity
natural sourced
Packaging
100g
Price
$124
Updated
2024/03/01
Sigma-Aldrich
Product number
W379312
Product name
D-Ribose
Purity
natural sourced
Packaging
5kg
Price
$648
Updated
2024/03/01
Sigma-Aldrich
Product number
W379312
Product name
D-Ribose
Purity
natural sourced
Packaging
1kg
Price
$746
Updated
2024/03/01
Sigma-Aldrich
Product number
R1757
Product name
D-(−)-Ribose
Purity
98%
Packaging
10g
Price
$50.4
Updated
2024/03/01
Sigma-Aldrich
Product number
R1757
Product name
D-(−)-Ribose
Purity
98%
Packaging
25g
Price
$65
Updated
2024/03/01
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D-Ribose Chemical Properties,Usage,Production

Description

D-ribose is an important five-carbon monosaccharide with the chemical formula C5H10O5. It is an important constituent of ribonucleic acid (RNA) and ATP, and plays an important role in the formation of life. It is also an important pharmaceutical intermediate for the production of various nucleic acid drugs.

Chemical Properties

D-Ribose is a five-carbon sugar with strong water solubility and sweet taste, also known as D-ribofuranose. It is used by all living cells and is an essential component in living organisms for energy production. It is widely present in the furan form.

Occurrence

Reported found in boiled crab, hen egg, catfish, whitefish, haddock, stored beef, stored veal, milk, applesauce, potato, rapeseed, roasted coffee, fresh coffee and shrimp.

Uses

D-Ribose is produced by microorganism fermentation of glucose in a fermentation culture medium without adding calcium carbonate.

Preparation

D-Ribose is obtained by using D-glucose as a raw material, inserting bacteria or Bacillus subtilis for fermentation, and separating and refining the fermentation product.(By fermentation technology)

Definition

ChEBI: D-ribose is a ribofuranose having D-configuration. It is a naturally occurring monosaccharide found in the cells and particularly in the mitochondria is essential in energy production.

Biological Functions

D-ribose is a penta-sugar precursor of some amino acids like glutamate, histidine, proline, and arginine. This substance is transformed into piruvate, enters Krebs's cycle, and has a crucial role in energetic metabolism; it is also involved in glycogen synthesis. The non-oxidative transketolase PPP reaction can be directly synthesized by transferring a keto group to glyceraldehyde 3-phoshate from fructose 6-phosphate. Both these substrates are intermediate products of glycolysis[1].

Biological Activity

D-ribose is a natural sugar that our bodies produce for a variety of purposes most notably encrgy in the form of ATP(adenosine triphosphate), which powers every cell in our body. Ribose is crucial for the synthesis of energy (ATP) and without it, your cells run out of energy and the health of the cell is compromised. Supplementing with ribose improves cell function by restoring energy.
One of the most vital organs to suffer energy depletion is the heart. That is why so much of the research on D-ribose has focused on the impact of supplement ribose in heart disease. Although ribose is classified as a sugar, when taken orally, it does not have any impact on blood sugar like glucose. Instead, it is used for energy production and energy recovery. Every cell in the body has the capacity to make ribose. But more ribose may be needed than the cell can produce when cells are metabolically stressed, such as with strenuous exercise or disease. When the cells are metabolically stressed they tend to consume more glucose rather than producing more ribose. This can dramatically affect recovery.

Biochem/physiol Actions

Ribose is an aldopentose monosaccharide that is phosphorylated into D-ribose 5-phosphate by ribokinase.

Side effects

D-ribose is a dietary supplement approved by the US FDA. It is generally considered safe for dosage of ribose is less than 15g/d. However, possible side effects include diarrhea, stomach discomfort, nausea, headache, and low blood sugar.

Purification Methods

Crystallise -D(-)-ribose from aqueous 80% EtOH, dry it under vacuum at 60o over P2O5 and store it in a vacuum desiccator. It exhibits a complex mutarotation with : [] D 10 -23.1o (1.5minutes), -21.3o (5minutes), -19.5o (10minutes), -19.1o (30minutes), -21.2o (60minutes), -23.1o (120minutes), -23.7o (300minutes), (c 4.5, H2O) [Phelps et al. J Am Chem Soc 56 748 1934]. 1H NMR in D2O at 44o shows 17% -pyranose, 59% -pyranose, 9% -furanose and 15% -furanose forms with furanose -H at 5.34ppm (J 3.0Hz) and -H at 5.31 (J 1.7Hz) [Angyal Adv Carbohydr Chem 42 15 1984, Angyal & Pickles Aust J Chem 25 1711 1972]. The phenylhydrazone crystallises from aqueous pyridine in yellow needles, m 163-164o, and the benzylphenylhydrazone has m 127-128o [Snowden J Am Chem Soc 72 808 1950.] [Beilstein 1 IV 4211.]

References

[1] Simonetta Croci. “Potassium bicarbonate and D-ribose effects on A72 canine and HTB-126 human cancer cell line proliferation in vitro.” Cancer Cell International 11 (2011): 30.

D-Ribose Preparation Products And Raw materials

Raw materials

D(+)-Glucose

Preparation Products

Ribavirin SPINOSAD Spinosad D Coenzyme A
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View Lastest Price from D-Ribose manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
D-Ribose 50-69-1
Price
US $999.00-800.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-21
Jinan Finer Chemical Co., Ltd
Product
D-Ribose 50-69-1
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
200mt
Release date
2022-02-16
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
D-Ribose 50-69-1
Price
US $180.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-04-23

50-69-1, D-RiboseRelated Search:

Ribostamycin sulfate Ribonucleic acid D(-)-Arginine D-(+)-ALLOSE L-(-)-TALOSE DNA, SINGLE STRANDED, IMM. ON CELLULOSE, FROM CALF THYMUS* Ribose,L-(+)-RIBOSE,L-RIBOSE RIBOSE-5-PHOSPHATE SODIUM SALT,D-RIBOSE-5-PHOSPHORIC ACID SODIUM SALT 2,3-O-Isopropylidene-D-ribonic gamma-lactone DNA，plasmid pSP64 .alpha.-Deoxy-D-ribos 1,2,3-Triacetyl-5-deoxy-D-ribose RIBOSE-5-PHOSPHATE BARIUM SALT Riboflavin METHYL 2-DEOXY-D-RIBOSE DNA polymeraseⅠfrom E.coli 1,2,3,5-Tetraacetyl-beta-D-ribos Deoxycytidine triphosphate trisodium salt

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