GSK 2239633A

Product Name: GSK 2239633A
CAS No.: 1240516-71-5
Chemical Name: GSK 2239633A
Synonyms: GSK 2239633A;GSK2239633A, 10 mM in DMSO;GSK-2239633A,inhibit,Inhibitor,CC chemokine receptor,CCR,GSK2239633A;Propanamide, N-[[3-[[3-[[(5-chloro-2-thienyl)sulfonyl]amino]-4-methoxy-1H-indazol-1-yl]methyl]phenyl]methyl]-2-hydroxy-2-methyl-;N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide
CBNumber: CB14189083
Molecular Formula: C24H25ClN4O5S2
Formula Weight: 549.06
MOL File: 1240516-71-5.mol

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GSK 2239633A Property

Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:152.46(Max Conc. mg/mL);277.67(Max Conc. mM)
form: Solid
pka: 7.03±0.30(Predicted)
color: White to off-white
InChIKey: YTEVTHHGQMUPHC-UHFFFAOYSA-N
SMILES: C(NCC1=CC=CC(CN2C3=C(C(OC)=CC=C3)C(NS(C3SC(Cl)=CC=3)(=O)=O)=N2)=C1)(=O)C(O)(C)C

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 7071
Product name: GSK2239633A
Purity: ≥98%(HPLC)
Packaging: 50
Price: $965
Updated: 2021/12/16

TRC

Product number: G797595
Product name: GSK2239633A
Packaging: 10mg
Price: $2310
Updated: 2021/12/16

TRC

Product number: G797595
Product name: GSK2239633A
Packaging: 1mg
Price: $290
Updated: 2021/12/16

ChemScene

Product number: CS-0018178
Product name: GSK2239633A
Purity: 99.77%
Packaging: 5mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0018178
Product name: GSK2239633A
Purity: 99.77%
Packaging: 10mg
Price: $850
Updated: 2021/12/16

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GSK 2239633A Chemical Properties,Usage,Production

Uses

GSK 2239633A, is an allosteric antagonist of human CCR4.

in vivo

Following intravenous dosing, plasma GSK2239633A displays rapid, bi-phasic distribution and slow terminal elimination (t_1/2: 13.5 hours), suggesting that GSK2239633A is a low to moderate clearance drug. Following oral dosing, blood levels of GSK2239633A reach C_max rapidly (median t_max: 1.0-1.5 hours). Estimated GSK2239633A bioavailability is low with a maximum value determined of only 16%^[1]. GSK2239633A (Compound 9) demonstrates good pharmacokinetic data in preclinical animal studies (bioavailability in rats and beagle dogs 85% and 97% respectively)^[3].

IC 50

[¹²⁵I]-TARC-CCR4: 7.96 (pIC₅₀)

storage

Store at -20°C

GSK 2239633A Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK 2239633A Suppliers

China 29 United States 4 Global 33

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
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InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354;
Email: support@targetmol.com
Country: United States
ProdList: 39035
Advantage: 58

Aladdin Scientific

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Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

1240516-71-5, GSK 2239633ARelated Search:

GSK2126458 1-[(3,4-dichlorophenyl)methyl]-N-[4-(hydroxymethyl)phenyl]-5-methyl-1H-1,2,3-triazole-4-carboxamide GSK-2256098 GSK369796 GSK2982772 MethanesulfonaMide, N-[5-[4-[5-[[(2R,6S)-2,6-diMethyl-4-Morpholinyl]Methyl]-2-oxazolyl]-1H-indazol-6-yl]-2-Methoxy-3-pyridinyl]-, rel- GSK2636771 GSK-2881078 gsk2200150a GSK-2018682 Lp-PLA2 -IN-1 GSK-3326595

GSK 2239633A

Propanamide, N-[[3-[[3-[[(5-chloro-2-thienyl)sulfonyl]amino]-4-methoxy-1H-indazol-1-yl]methyl]phenyl]methyl]-2-hydroxy-2-methyl-

GSK-2239633A,inhibit,Inhibitor,CC chemokine receptor,CCR,GSK2239633A

N-[(3-{[3-{[(5-Chloro-2-thienyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

GSK2239633A, 10 mM in DMSO

1240516-71-5

C24H25ClN4O5S2