L-2-Chlorophenylglycine

Product Name: L-2-Chlorophenylglycine
CAS No.: 141315-50-6
Chemical Name: L-2-Chlorophenylglycine
Synonyms: (R)-2-AMINO-2-(2-CHLOROPHENYL)ACETIC ACID;NSC63256;ST5452327;-(+)-2-(2-ChL;Clopidogrel-10;NCIOpen2_000290;Clopidogrel Impurity 66;Clopidogrel Impurities3;(S)-2-Chorophenylglycine;L-(2-CHLOROPHENYL)GLYCINE
CBNumber: CB1422058
Molecular Formula: C8H8ClNO2
Formula Weight: 185.61
MOL File: 141315-50-6.mol

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L-2-Chlorophenylglycine Property

Melting point:: 182-187 °C(lit.)
Boiling point:: 318.8±32.0 °C(Predicted)
Density: 1.392±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: Solid
pka: 1.69±0.10(Predicted)
color: White to off-white
optical activity: [α]/D 79.0 to 90.0°, c =1 in methanol
[α]20/D +79°, c =1% in chloroform
CAS DataBase Reference: 141315-50-6(CAS DataBase Reference)

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Safety

WGK Germany: 3
HS Code: 2922498590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 638943
Product name: L-(+)-2-Chlorophenylglycine
Purity: 95%
Packaging: 5G
Price: $156
Updated: 2023/06/20

TCI Chemical

Product number: C2431
Product name: L-(+)-2-(2-Chlorophenyl)glycine
Purity: >98.0%(HPLC)
Packaging: 1g
Price: $44
Updated: 2021/12/16

TCI Chemical

Product number: C2431
Product name: L-(+)-2-(2-Chlorophenyl)glycine
Purity: >98.0%(HPLC)
Packaging: 5g
Price: $132
Updated: 2021/12/16

TRC

Product number: C350555
Product name: L-2-Chlorophenylglycine
Packaging: 25g
Price: $65
Updated: 2021/12/16

Usbiological

Product number: 453125
Product name: L-2-Chlorophenylglycine
Packaging: 100mg
Price: $305
Updated: 2021/12/16

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L-2-Chlorophenylglycine Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

L-2-Chlorophenylglycine

Synthesis

143-33-9

89-98-5

86169-24-6

The general procedure for the synthesis of (R)-2-amino-2-(2-chlorophenyl)acetic acid from sodium cyanide and o-chlorobenzaldehyde is as follows: 2-chlorophenylglycine was prepared according to the synthetic method described in Scheme 1. This was done as follows: 2-chlorobenzaldehyde, ammonium bicarbonate (NH4HCO3; 23.7 g) and sodium cyanide (NaCN; 14.7 g) were dissolved in a mixed solution of 500 ml of methanol and 500 ml of water, and the reaction was stirred for 5 hours at 65-70 °C. Upon completion of the reaction, the solution was concentrated and transferred to an autoclave, where 45% sodium hydroxide (NaOH) solution was added and refluxed at 120°C for 4 hours. After the reaction mixture was cooled, 2 g of activated carbon was added and stirred for 10 minutes for decolorization. The activated carbon was removed by filtration and the pH of the filtrate was adjusted to 7-8 with 50% sulfuric acid (H2SO4).Subsequently, the precipitate was collected by filtration and washed with distilled water to give a final product of 27 g (58% yield) of 2-chlorophenylglycine. The compound had a specific optical rotation of +0.16 (C=1, 1N HCl) and a melting point of 185.4-186.8 °C.

References

[1] Patent: US2004/176637, 2004, A1. Location in patent: Page 3

L-2-Chlorophenylglycine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from L-2-Chlorophenylglycine manufacturers

Career Henan Chemical Co

Product: L-2-Chlorophenylglycine 141315-50-6
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-21

141315-50-6, L-2-ChlorophenylglycineRelated Search:

2-Chlorobenzoyl chloride 2-(2-Chlorophenyl)acetonitrile 2-Chlorophenol Glycine 2'-Chloroacetophenone Sodium glycinate ALTRENOGEST 2-Chlorobenzonitrile 2-Chlorobenzaldehyde L-Phenylglycine 4-Hydroxy-D-(-)-2-phenylglycine 2-Chlorobenzoic acid Ethyl 2-(Chlorosulfonyl)acetate 6-Aminocaproic acid 4-Aminophenylacetic acid α-Lipoic Acid D-2-Phenylglycine Sodium hydroxymethylglycinate

(S)-AMINO-(2-CHLORO-PHENYL)-ACETIC ACID

(S)-(+)-ALPHA-AMINO-(2-CHLOROPHENYL)ACETIC ACID

(S)-(+)-A-AMINO-(2-CHLOROPHENYL)ACETIC ACID

(S)-(+)-2-CHLOROPHENYLGLYCINE

S-(+)-2-(2-CHLORO PHENYL)GLYCINE

L-(+)-2-CHLOROPHENYLGLYCINE

L-(2-CHLOROPHENYL)GLYCINE

(L)-(-)-ALPHA-AMINO-(2-CHLOROPHENYL)ACETIC ACID

(S)-(+)-(o-Chlorophenyl)glycine

1-(+)-2-chlorophenylglycine

(2S)-amino(2-chlorophenyl)ethanoic acid

L(+)-O-CHLOROPHENYLGLYCINE

Amino chlorophenyl acetic acid

(S)-2-Chorophenylglycine

(S)-2-Chlorophenylglycinol

L-(+)-2-Chlorophenylglycine,(S)-αAmino-(2-chlorophenyl)acetic acid, L-2-Chlorophenylglycine

L-(+)-chlorophenyl glycine

L-(+)-2-(2-Chlorophenyl)glycine

(R)-2-AMINO-2-(2-CHLOROPHENYL)ACETIC ACID

(S)-α-Amino-(2-chlorophenyl)acetic acid, L-2-Chlorophenylglycine

Clopidogrel-10

(+)-2-Chloro-L-phenylglycine, 95%

L-2-Chlorophenylglycine (S)-alpha-Amino-(2-chlorophenyl)acetic acid

Benzeneacetic acid, .alpha.-amino-2-chloro-, (.alpha.S)-

Benzeneacetic acid, a-amino-2-chloro-, (aS)-

L-(+)-2-Chlorophenylglycine 95%

2-[(2-chlorophenyl)amino]ethanoic acid

N-(2-chlorophenyl)glycine

NCIOpen2_000290

NSC63256

ST5452327

<small>L</small>-(+)-2-(2-Chlorophenyl)glycine

Benzeneacetic acid, α-amino-2-chloro-, (αS)-

(2S)-2-azaniumyl-2-(2-chlorophenyl)acetate

Clopidogrel Impurity 66

L-(+)-2-(2-Chlorophenyl)glycine &gt

(+)-2-Chloro-L-phenylglycine

-(+)-2-(2-ChL

(S)-2-Amino-2-(2-chlorophenyl)aceticaci

2-Chloro-L-(+)-2-phenylglycine

L-2-Chlorophenylglycine USP/EP/BP

(S)-2-Amino-2-(2-chlorophenyl)acetic acid (Clopidogrel Impurity)

Clopidogrel Impurities192

Clopidogrel Impurities3

Clopidogrel EP Impurity 26

<sc>L</sc>-(+)-2-Chlorophenylglycine

141315-50-6

ClC6H4CHNH2CO2H

C8ClH8NO2

C9H8INO2

Carboxylic acid

Peptide Synthesis

Phenylglycine Derivatives

Specialty Synthesis

Unnatural Amino Acid Derivatives

Amino ACIDS SERIES

pharmacetical

chiral