5-Fluoro-2-nitrotoluene
- Product Name
- 5-Fluoro-2-nitrotoluene
- CAS No.
- 446-33-3
- Chemical Name
- 5-Fluoro-2-nitrotoluene
- Synonyms
- 4-FLUORO-2-METHYL-1-NITROBENZENE;3-FLUORO-6-NITROTOLUENE;uoro-2-nitrotoL;Fluoro-2-nitrotolu;Fluoronitrotoluene5;5-Fluoro-2-nitrotolu;5-FLUORO-2-NITROTOLUENE;5-Fluoro-2-nitrotoulene;2-NITRO-5-FLUORO TOLUENE;5-fluoro-2-nitrotoluenen
- CBNumber
- CB1429466
- Molecular Formula
- C7H6FNO2
- Formula Weight
- 155.13
- MOL File
- 446-33-3.mol
5-Fluoro-2-nitrotoluene Property
- Melting point:
- 28°C
- Boiling point:
- 97-98 °C/10 mmHg (lit.)
- Density
- 1.272 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.527(lit.)
- Flash point:
- 190 °F
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to lump to clear liquid
- color
- White or Colorless to Yellow
- Specific Gravity
- 1.272
- BRN
- 2046652
- InChI
- InChI=1S/C7H6FNO2/c1-5-4-6(8)2-3-7(5)9(10)11/h2-4H,1H3
- InChIKey
- JHFOWEGCZWLHNW-UHFFFAOYSA-N
- SMILES
- C1([N+]([O-])=O)=CC=C(F)C=C1C
- CAS DataBase Reference
- 446-33-3(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzene, 4-fluoro-2-methyl-1-nitro-(446-33-3)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36-45-37-28A
- RIDADR
- UN 2811
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29049085
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- F12405
- Product name
- 5-Fluoro-2-nitrotoluene
- Purity
- 97%
- Packaging
- 50g
- Price
- $264
- Updated
- 2023/01/07
- Product number
- F0301
- Product name
- 5-Fluoro-2-nitrotoluene
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $27
- Updated
- 2025/07/31
- Product number
- F0301
- Product name
- 5-Fluoro-2-nitrotoluene
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $105
- Updated
- 2025/07/31
- Product number
- F597103
- Product name
- 4-Fluoro-2-methyl-1-nitrobenzene
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- F597103
- Product name
- 4-Fluoro-2-methyl-1-nitrobenzene
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
5-Fluoro-2-nitrotoluene Chemical Properties,Usage,Production
Chemical Properties
colorless to light yellow liquid
Industrial uses
5-Fluoro-2-nitrotoluene can be used to synthesize 5-fluoro-2-nitrobenzaldehyde, and the resulting substance can be used as an intermediate in pharmaceutical chemistry and organic synthesis, and can be used to prepare herbicides, plant growth regulators, etc.
Synthesis
352-70-5
446-33-3
The general procedure for the synthesis of 5-fluoro-2-nitrotoluene from 3-fluorotoluene is as follows: 1-fluoro-3-methylbenzene (9) (30 g, 273 mmol) was added slowly and dropwise to a stirred 90% aqueous nitric acid solution (100 mL) at 0-5 °C. The reaction mixture was stirred for 0.5 min and poured into ice water. The aqueous phase was extracted with dichloromethane (3 x 50 mL), the organic phases were combined and washed with saturated aqueous sodium bicarbonate (100 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (elution gradient: 0.5% to 3.3% ethyl acetate in petroleum ether) to afford the target product 5-fluoro-2-nitrotoluene as a yellow oil (16 g, 38% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 2.64 (s, 3H), 7.01-7.06 (m, 2H), 8.07 (m, 1H).
References
[1] Patent: US2010/324043, 2010, A1. Location in patent: Page/Page column 26-27
[2] Chemische Berichte, 1929, vol. 62, p. 1804
[3] Journal of the American Chemical Society, 1959, vol. 81, p. 94,95, 97
[4] Journal of Organic Chemistry, 1961, vol. 26, p. 3351 - 3356
[5] Patent: US6020379, 2000, A
5-Fluoro-2-nitrotoluene Preparation Products And Raw materials
Raw materials
Preparation Products
5-Fluoro-2-nitrotoluene Suppliers
- Tel
- --
- Fax
- --
- chemcontrol@nextra.sk
- Country
- Slovakia
- ProdList
- 6700
- Advantage
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View Lastest Price from 5-Fluoro-2-nitrotoluene manufacturers
- Product
- 5-Fluoro-2-nitrotoluene 446-33-3
- Price
- US $1.00-28.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20000KG
- Release date
- 2024-07-29
- Product
- 5-Fluoro-2-nitrotoluene 446-33-3
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30
- Product
- 5-Fluoro-2-nitrotoluene 446-33-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.6%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18