6-Fluoroquinaldine
- Product Name
- 6-Fluoroquinaldine
- CAS No.
- 1128-61-6
- Chemical Name
- 6-Fluoroquinaldine
- Synonyms
- AKOS 1002;6-FLUOROQUINALDINE;6-Fluoroquildine, 98%;6-FLUORO-2-METHYLQUINOLINE;2-METHYL-6-FLUOROQUINOLINE;6-flouro-2-methyl quinoline;Quinoline, 6-fluoro-2-methyl-;6-Fluoro-2-methylquinoline>6-Fluoro-2-methylquinoline97%;6-Fluoro-2-methylquinoline 97%
- CBNumber
- CB1440762
- Molecular Formula
- C10H8FN
- Formula Weight
- 161.18
- MOL File
- 1128-61-6.mol
6-Fluoroquinaldine Property
- Melting point:
- 49-53 °C (lit.)
- Boiling point:
- 99 °C / 3mmHg
- Density
- 1.1465 (estimate)
- Flash point:
- >230 °F
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Soluble in Chloroform.
- pka
- 5.16±0.43(Predicted)
- form
- powder to crystal
- color
- White to Almost white
- BRN
- 1281677
- CAS DataBase Reference
- 1128-61-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 38-41-36/37/38
- Safety Statements
- 26-37/39-36
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29334990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 640484
- Product name
- 6-Fluoro-2-methylquinoline
- Purity
- 97%
- Packaging
- 5g
- Price
- $40.2
- Updated
- 2025/07/31
- Product number
- 640484
- Product name
- 6-Fluoro-2-methylquinoline
- Purity
- 97%
- Packaging
- 1g
- Price
- $35
- Updated
- 2023/06/20
- Product number
- F0300
- Product name
- 6-Fluoro-2-methylquinoline
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $98
- Updated
- 2025/07/31
- Product number
- F595900
- Product name
- 6-Fluoro-2-methylquinoline
- Packaging
- 1g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- F595900
- Product name
- 6-Fluoro-2-methylquinoline
- Packaging
- 10g
- Price
- $1100
- Updated
- 2021/12/16
6-Fluoroquinaldine Chemical Properties,Usage,Production
Chemical Properties
brown powder or granules
Uses
Metal-free transfer hydrogenation of 6-fluoro-2-methylquinoline by employing several chiral Br?nsted acid catalysts was carried out in combination with dihydropyridines as the hydride source in asymmetric metal-free synthesis of fluoroquinolones by organocatalytic hydrogenation. Hydrogenation product of 6-fluoro-2-methylquinoline is the key intermediate of the antibacterial agent.
Uses
Quinoline derivative as a highly potent thrombin receptor antagonist
Synthesis
42835-89-2
1128-61-6
General procedure for the synthesis of 6-fluoro-1,2,3,4-tetrahydro-2-methylquinoline from 6-fluoro-1,2,3,4-tetrahydro-2-methylquinoline: 6-fluoro-1,2,3,4-tetrahydro-2-methylquinoline (0.50 mmol), FeCl2 (1.9 mg, 1.5 × 10-2 mmol), DMSO (31.2 mg, 0.4 mmol) and p-xylene (1 mL). The reaction mixture was stirred using a balloon at 110 °C and oxygen atmosphere and the progress of the reaction was monitored by TLC. Upon completion of the reaction, the mixture was cooled to room temperature and purified by fast chromatography (eluent: hexane-ethyl acetate, 10:1) to afford the target product 6-fluoro-2-methylquinoline in 70% yield. 6-fluoro-2-methylquinoline was a colorless oil.1H NMR (400 MHz, CDCl3): δ = 8.93 (m, 1H), 8.10 (m, 1H) , 7.64 (d, J=4.0 Hz, 1H), 7.54 (m, 1H), 7.43-7.35 (m, 2H), 2.82 (s, 3H).13C NMR (100 MHz, CDCl3): δ=149.2, 147.3, 137.1, 136.3, 129.6, 128.3, 126.3, 125.9. 120.8, 18.2. HRMS: m/z calculated value of [C10H9FN+H]+: 144.0813; measured value: 144.0813.
References
[1] Angewandte Chemie - International Edition, 2016, vol. 55, # 40, p. 12224 - 12227
[2] Angew. Chem., 2016, vol. 128, # 40, p. 12412 - 12415,4
[3] Angewandte Chemie - International Edition, 2013, vol. 52, # 27, p. 6983 - 6987
[4] Ross. Khim. Zh., 2013, vol. 125, # 27, p. 7121 - 7125,5
[5] Journal of the American Chemical Society, 2015, vol. 137, # 33, p. 10652 - 10658
6-Fluoroquinaldine Preparation Products And Raw materials
Raw materials
Preparation Products
6-Fluoroquinaldine Suppliers
- Tel
- --
- Fax
- --
- sales@loba.co.at
- Country
- Austria
- ProdList
- 900
- Advantage
- 61
View Lastest Price from 6-Fluoroquinaldine manufacturers
- Product
- 6-Fluoro-2-methylquinoline 1128-61-6
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-24
- Product
- 6-Fluoro-2-methylquinoline 1128-61-6
- Price
- US $1786.00/Kg
- Min. Order
- 1Kg
- Purity
- 98
- Supply Ability
- 500 Kg
- Release date
- 2024-09-06
- Product
- 6-Fluoroquinaldine 1128-61-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000MT
- Release date
- 2024-07-17