ChemicalBook > CAS DataBase List > 6-Fluoroquinaldine

6-Fluoroquinaldine

Product Name: 6-Fluoroquinaldine
CAS No.: 1128-61-6
Chemical Name: 6-Fluoroquinaldine
Synonyms: AKOS 1002;6-FLUOROQUINALDINE;6-Fluoroquildine, 98%;6-FLUORO-2-METHYLQUINOLINE;2-METHYL-6-FLUOROQUINOLINE;6-flouro-2-methyl quinoline;Quinoline, 6-fluoro-2-methyl-;6-Fluoro-2-methylquinoline>6-Fluoro-2-methylquinoline97%;6-Fluoro-2-methylquinoline 97%
CBNumber: CB1440762
Molecular Formula: C10H8FN
Formula Weight: 161.18
MOL File: 1128-61-6.mol

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6-Fluoroquinaldine Property

Melting point:: 49-53 °C (lit.)
Boiling point:: 99 °C / 3mmHg
Density: 1.1465 (estimate)
Flash point:: >230 °F
storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in Chloroform.
pka: 5.16±0.43(Predicted)
form: powder to crystal
color: White to Almost white
BRN: 1281677
CAS DataBase Reference: 1128-61-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 38-41-36/37/38
Safety Statements: 26-37/39-36
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29334990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 640484
Product name: 6-Fluoro-2-methylquinoline
Purity: 97%
Packaging: 5g
Price: $40.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: 640484
Product name: 6-Fluoro-2-methylquinoline
Purity: 97%
Packaging: 1g
Price: $35
Updated: 2023/06/20

TCI Chemical

Product number: F0300
Product name: 6-Fluoro-2-methylquinoline
Purity: >98.0%(GC)
Packaging: 5g
Price: $98
Updated: 2025/07/31

TRC

Product number: F595900
Product name: 6-Fluoro-2-methylquinoline
Packaging: 1g
Price: $140
Updated: 2021/12/16

TRC

Product number: F595900
Product name: 6-Fluoro-2-methylquinoline
Packaging: 10g
Price: $1100
Updated: 2021/12/16

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6-Fluoroquinaldine Chemical Properties,Usage,Production

Chemical Properties

brown powder or granules

Uses

Metal-free transfer hydrogenation of 6-fluoro-2-methylquinoline by employing several chiral Br?nsted acid catalysts was carried out in combination with dihydropyridines as the hydride source in asymmetric metal-free synthesis of fluoroquinolones by organocatalytic hydrogenation. Hydrogenation product of 6-fluoro-2-methylquinoline is the key intermediate of the antibacterial agent.

Uses

Quinoline derivative as a highly potent thrombin receptor antagonist

Synthesis

42835-89-2

1128-61-6

General procedure for the synthesis of 6-fluoro-1,2,3,4-tetrahydro-2-methylquinoline from 6-fluoro-1,2,3,4-tetrahydro-2-methylquinoline: 6-fluoro-1,2,3,4-tetrahydro-2-methylquinoline (0.50 mmol), FeCl2 (1.9 mg, 1.5 × 10-2 mmol), DMSO (31.2 mg, 0.4 mmol) and p-xylene (1 mL). The reaction mixture was stirred using a balloon at 110 °C and oxygen atmosphere and the progress of the reaction was monitored by TLC. Upon completion of the reaction, the mixture was cooled to room temperature and purified by fast chromatography (eluent: hexane-ethyl acetate, 10:1) to afford the target product 6-fluoro-2-methylquinoline in 70% yield. 6-fluoro-2-methylquinoline was a colorless oil.1H NMR (400 MHz, CDCl3): δ = 8.93 (m, 1H), 8.10 (m, 1H) , 7.64 (d, J=4.0 Hz, 1H), 7.54 (m, 1H), 7.43-7.35 (m, 2H), 2.82 (s, 3H).13C NMR (100 MHz, CDCl3): δ=149.2, 147.3, 137.1, 136.3, 129.6, 128.3, 126.3, 125.9. 120.8, 18.2. HRMS: m/z calculated value of [C10H9FN+H]+: 144.0813; measured value: 144.0813.

References

[1] Angewandte Chemie - International Edition, 2016, vol. 55, # 40, p. 12224 - 12227
[2] Angew. Chem., 2016, vol. 128, # 40, p. 12412 - 12415,4
[3] Angewandte Chemie - International Edition, 2013, vol. 52, # 27, p. 6983 - 6987
[4] Ross. Khim. Zh., 2013, vol. 125, # 27, p. 7121 - 7125,5
[5] Journal of the American Chemical Society, 2015, vol. 137, # 33, p. 10652 - 10658

6-Fluoroquinaldine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 6-Fluoroquinaldine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 6-Fluoro-2-methylquinoline 1128-61-6
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-24

R&D Scientific Inc.

Product: 6-Fluoro-2-methylquinoline 1128-61-6
Price: US $1786.00/Kg
Min. Order: 1Kg
Purity: 98
Supply Ability: 500 Kg
Release date: 2024-09-06

Shaanxi Dideu Medichem Co. Ltd

Product: 6-Fluoroquinaldine 1128-61-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000MT
Release date: 2024-07-17

1128-61-6, 6-FluoroquinaldineRelated Search:

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