ChemicalBook > CAS DataBase List > Hexetidine

Hexetidine

Product Name
Hexetidine
CAS No.
141-94-6
Chemical Name
Hexetidine
Synonyms
Hexoral;Hextril;Triocil;Glypesin;Oraldene;Sterisil;NSC 17764;HEXETIDINE;Hexetidine CRS;RARECHEM AB PP 1426
CBNumber
CB1442069
Molecular Formula
C21H45N3
Formula Weight
339.6
MOL File
141-94-6.mol
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Hexetidine Property

Melting point:
25°C
Boiling point:
160 °C/0.4 mmHg (lit.)
Density 
0.889 g/mL at 25 °C (lit.)
refractive index 
1.4649
Flash point:
70°C
storage temp. 
2-8°C
solubility 
acetone: soluble(lit.)
pka
8.3(at 25℃)
color 
Clear Colourless
Water Solubility 
Not miscible or difficult to mix in water.
Merck 
14,4703
BRN 
161071
InChIKey
DTOUUUZOYKYHEP-UHFFFAOYSA-N
LogP
7.150 (est)
CAS DataBase Reference
141-94-6(CAS DataBase Reference)
EPA Substance Registry System
5-Pyrimidinamine, 1,3-bis(2-ethylhexyl)hexahydro-5-methyl- (141-94-6)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/38-36/37/38
Safety Statements 
26-36
WGK Germany 
3
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
2933599590
Hazardous Substances Data
141-94-6(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H0325000
Product name
Hexetidine
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
h0325000
Price
$153
Updated
2024/03/01
Alfa Aesar
Product number
L18699
Product name
Hexetidine, mixture of stereoisomers, 97%
Packaging
5g
Price
$65.8
Updated
2021/12/16
Alfa Aesar
Product number
L18699
Product name
Hexetidine, mixture of stereoisomers, 97%
Packaging
25g
Price
$221
Updated
2021/12/16
TRC
Product number
H925013
Product name
Hexetidine, mixture of stereoisomers
Packaging
1g
Price
$65
Updated
2021/12/16
Usbiological
Product number
451901
Product name
Hexetidine, Mixture of Stereoisomers
Packaging
500mg
Price
$305
Updated
2021/12/16
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Hexetidine Chemical Properties,Usage,Production

Chemical Properties

Liquid.Soluble in methanol, benzene, and petroleum ether; insoluble in water.

Chemical Properties

Hexetidine is a colorless or faint yellow-colored oily liquid with a characteristic amine odor.

Originator

Sterisil,Warner Lambert,US,1956

Uses

Hexetidine, mixture of stereoisomers is an antibacterial and antifungal agent. Used in plant-derived composite antimicrobial agent and application thereof in cosmetic.

Uses

Involved in studies:

  • To identify pure liquid salt forms of aspirin
  • Of alkyl based selective displacers for protein purification via ion exchange chromatography
  • Of the in vivo application of models for testing drugs against nonreplicating Mycobacterium tuberculosis
  • Nutrient-sensitized screening for drugs that shift the energy metabolism from mitochondrial respiration to glycolysis
  • Inhibition of angiogensis
  • Screening antimalarial drugs

Uses

Fungicide, bactericide, algicide, antistatic agent for synthetics, insect repellent, medicine (antifungal agent).

Production Methods

Hexetidine is prepared by hydrogenation under pressure of 1,3- bis(2-ethylhexyl)-5-methyl-4-nitrohexahydropyriminine at 100°C using Raney nickel as a catalyst.

Definition

ChEBI: 1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine is an organonitrogen heterocyclic compound and an organic heteromonocyclic compound.

Manufacturing Process

Nitroethane and formaldehyde are first reacted to give 2-methyl-2-nitro-1,3- propanediol. This is reacted with 2-ethylhexylamine and formaldehyde to give 5-nitro-1,3-bis(2-ethylhexyl)-5-methyl-hexahydropyrimidine.
To a hydrogenation apparatus containing 500 ml of methanol and 10 g of Raney nickel catalyst were continuously added over a period of one hour, 240 g of 5-nitro-1,3-bis(2-ethylhexyl)-5-methylhexahydropyrimidine. During the one-hour period, the resulting mixture was hydrogenated at approximately 1,000 pounds per square inch utilizing room temperature as the initial temperature and gradually increasing the temperature to about 70°C. At the end of the one-hour period, hydrogenation was stopped. The reaction mixture was first filtered to remove the catalyst and was then distilled at atmospheric pressure at a temperature of 70°C to remove methanol. 197.5 g of 5-amino- 1,3-bis(2-ethylhexyl)-5-methylhexahydropyrimidine were collected.

Therapeutic Function

Antifungal

General Description

The effectiveness of a hexetidine mouthwash in reducing supragingival plaque and gingival inflammation has been examined.

Hazard

Combustible.

Pharmaceutical Applications

Hexetidine is used as an antimicrobial preservative in cosmetics and nonparenteral pharmaceutical formulations. Therapeutically, hexetidine is mainly used as a 0.1% w/v solution in mouthwash formulations for the prevention and treatment of minor local infections, gingivitis, and mouth ulcers.

Safety

Hexetidine is mainly used in mouthwashes as a bactericidal and fungicidal antiseptic. It is also used as an antimicrobial preservative and is generally regarded as a relatively nontoxic and nonirritant material at concentrations up to 0.1% w/v. Allergic contact dermatitis and altered olfactory and taste perception have occasionally been reported. Hexetidine is toxic when administered intravenously.
Solutions of hexetidine in oil at concentrations of 5–10% w/v cause strong primary irritations without sensitization in humans. Long-term toxicological studies of up to 0.1% w/w of hexetidine in food for 1 year do not show any toxic effect. Fetotoxicity, embryotoxicity, and teratogenicity studies in rats of doses up to 50 mg/kg/day exhibit no sign of toxicity.
LD100 (cat, IV): 5–20 mg/kg
LD50 (dog, oral): 1.60 g/kg
LD50 (mouse, IP): 0.142 g/kg
LD50 (mouse, oral): 1.52 g/kg
LD50 (rat, oral): 0.61–1.43 g/kg

storage

Hexetidine is stable and should be stored in a well-closed container in a cool, dry place. Brass and copper equipment should not be used for the handling or storage of hexetidine.

Incompatibilities

Hexetidine is incompatible with strong oxidizing agents. Salts are formed with mineral and organic acids; strong acids cause opening of the hexahydropyrimidine ring, releasing formaldehyde.

Regulatory Status

Included in nonparenteral formulations licensed in Europe.

Hexetidine Preparation Products And Raw materials

Raw materials

Preparation Products

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Hexetidine Suppliers

Chongqing Xinboyao Biological Technology Co., LTD
Tel
19122915778
Email
1549869036@qq.com
Country
China
ProdList
286
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2127
Advantage
70
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070 13913916777;
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
17840
Advantage
64
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12338
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
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View Lastest Price from Hexetidine manufacturers

Dideu Industries Group Limited
Product
Hexetidine 141-94-6
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-19
Zhuozhou Wenxi import and Export Co., Ltd
Product
Hexetidine 141-94-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Hexetidine 141-94-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

141-94-6, HexetidineRelated Search:


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