EMRK2, HUMAN
Description Source Background- Product Name
- EMRK2, HUMAN
- Chemical Name
- EMRK2, HUMAN
- Synonyms
- EMRK2;FLT-1;VGFR1;VEGF-R1;EMRK2, HUMAN;FLT-1, HUMAN;Flt1 active human;VEGF RECEPTOR-1, HUMAN;FLT-1, HUMAN, 17AA NEAR CT;Human FLT1 Protein, Fc Tag
- CBNumber
- CB1447105
- Formula Weight
- 0
- MOL File
- Mol file
EMRK2, HUMAN Property
- storage temp.
- -70°C
- form
- buffered aqueous glycerol solution
- biological source
- human
- Specific Activity
- 30-40nmol/min·mg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SRP0348
- Product name
- Flt1 active human
- Purity
- recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE)
- Packaging
- 10μg
- Price
- $603
- Updated
- 2025/07/31
- Product number
- F6307
- Product name
- FLT1 (784-end), active, GST tagged human
- Purity
- PRECISIO? Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
- Packaging
- 10μg
- Price
- $479
- Updated
- 2025/07/31
- Product number
- 135239
- Product name
- VEGFR-1
- Packaging
- 50ug
- Price
- $539
- Updated
- 2021/12/16
- Product number
- 135240
- Product name
- VEGFR-1
- Packaging
- 100ug
- Price
- $576
- Updated
- 2021/12/16
- Product number
- BITP1425
- Product name
- Recombinant Human Vascular Endothelial Growth Factor receptor-1
- Packaging
- 2μg
- Price
- $75
- Updated
- 2021/12/16
EMRK2, HUMAN Chemical Properties,Usage,Production
Uses
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Biological Activity
FLT1 (fms-related tyrosine kinase 1) or VEGFR (vascular endothelial growth factor receptor) is implicated in angiogenesis in tumors, which plays a key role in tumorigenesis, invasion and metastasis of tumors, especially the malignant ones. In human circulation, angiogenesis is balanced by soluble FLT1 (sFLT1) and VEGF. An imbalance leads to multiple conditions such as pre-eclampsia. sFLT1 plays an essential role in the angiogenesis of placenta. An overexpression of this protein in placenta is associated with prenatal arsenic exposure and thus, reduced birth weight.
Description
Soluble FLT1 Human Recombinant produced in baculovirus is monomeric, glycosylated, polypeptide containing 687 amino acids and having a molecular mass of 96 kDa. The soluble receptor protein contains only the first 6 extracellular domains, which contain all the information necessary for binding of VEGF.
The FLT1 is purified by proprietary chromatographic techniques.
Source
Insect Cells
Background
Endothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1), VEGFR-3 (Flt-4). Their expression is almost exclusively restricted to endothelial cells, but VEGFR-1 can also be found on monocytes, dendritic cells and on trophoblast cells. The flt-1 gene was first described in 1990. The receptor contains seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular splited tyrosine kinase domain. Compared to VEGFR-2 the Flt-1 receptor has a higher affinity for VEGF but a weaker signaling activity. VEGFR-1 thus leads not to proliferation of endothelial cells, but mediates signals for differentiation. Interestingly a naturally occuring soluble variant of VEGFR-1 (sVEGFR-1) was found in HUVE supernatants in 1996, which is generated by alternative splicing of the flt-1 mRNA. The biological functions of sVEGFR-1 still are not clear, but it seems to be an endogenous regulator of angiogenesis, binding VEGF with the same affinity as the full-length receptor.
EMRK2, HUMAN Preparation Products And Raw materials
Raw materials
Preparation Products
EMRK2, HUMAN Suppliers
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