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TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATE

Product Name
TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATE
CAS No.
156866-52-3
Chemical Name
TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATE
Synonyms
4-[(Boc-amino)methyl]benzaldehyde;N-Boc-4-(Aminomethyl)benzaldehyde;tert-butyl 4-formylbenzylcarbamate;TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATE;4-(N-TERTBUTOXYAMINOMETHYL)BENZALDEHYDE;4-(Aminomethyl)benzaldehyde, N-BOC protected;Tert-butylN-[(4-formylphenyl)methyl]carbamate;(4-formyl-benzyl)-carbamic acid t-butyl ester;(4-Formylbenzyl)carbamic acid tert-butyl ester;tert-Butyl (4-formylbenzyl)carbamate, 4-{[(tert-Bu
CBNumber
CB1450169
Molecular Formula
C13H17NO3
Formula Weight
235.28
MOL File
156866-52-3.mol
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TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATE Property

Melting point:
83 °C
Boiling point:
389.0±25.0 °C(Predicted)
Density 
1.108±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
crystalline powder
pka
11.92±0.46(Predicted)
color 
Pale yellow
CAS DataBase Reference
156866-52-3
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38-51
Safety Statements 
22-26-36/37/39
Hazard Note 
Harmful
HS Code 
2922390090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
B129565
Product name
tert-Butyl4-Formylbenzylcarbamate
Packaging
50mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB139436
Product name
tert-Butyl 4-formylbenzylcarbamate
Packaging
250mg
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB139436
Product name
tert-Butyl 4-formylbenzylcarbamate
Packaging
500mg
Price
$80
Updated
2021/12/16
SynQuest Laboratories
Product number
4756-1-Y8
Product name
4-(Aminomethyl)benzaldehyde, N-Boc protected
Packaging
250mg
Price
$96
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB139436
Product name
tert-Butyl 4-formylbenzylcarbamate
Packaging
1g
Price
$110
Updated
2021/12/16
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TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATE Chemical Properties,Usage,Production

Synthesis

123986-64-1

156866-52-3

General procedure for the synthesis of tert-butyl 4-formylbenzylcarbamate from tert-butyl 4-(hydroxymethyl)benzylcarbamate: tert-butyl 4-(hydroxymethyl)benzylcarbamate (2.20 g, 9.2 mmol) was dissolved in dichloromethane (DCM, 100 ml), and manganese dioxide (MnO2, 8.18 g, 92 mmol, 10 equiv) was added. The resulting suspension was stirred at room temperature for 3 hours. After completion of the reaction, the reaction mixture was filtered through diatomaceous earth to remove insoluble impurities. The filtrate was concentrated under reduced pressure to afford tert-butyl 4-formylbenzylcarbamate as a white solid (2.18 g, 9.2 mmol, 100% yield). Thin layer chromatography (TLC) analysis showed Rf = 0.62 (Expander: DCM/ethyl acetate, 9:1). Infrared spectroscopy (IR) showed characteristic absorption peaks. Nuclear magnetic resonance hydrogen spectrum (1H NMR, 300 MHz, CDCl3) δ = 10.0 (s, 1H, CHO), 7.85 (d, J = 8.1 Hz, 2H, ArCH adjacent to CHO), 7.45 (d, J = 8.1 Hz, 2H, ArCH adjacent to CH2NHBoc), 4.99 (bs. 1H, NHBoc), 4.40 (d, J = 5.7 Hz, 2H, CH2NHBoc), 1.47 (s, 9H, C(CH3)3). Nuclear magnetic resonance carbon spectrum (13C NMR, 75 MHz, CDCl3) δ = 191.9 (CHO), 155.9 (CO), 145.9 (ArCCH2NHBoc), 135.5 (ArCCHO), 130.1 (ArCH adjacent to CHO), 127.6 (ArCH adjacent to CH2NHBoc), 85.1 (C(CH3)3), 44.3 (CH2NHBoc), 28.3 (C(CH3)3). High-resolution mass spectrometry (HRMS, ESI+) showed an m/z of 258.1101 (calculated value: C13H19NO3Na [M+Na]+, 258.1101; measured value: 258.1094). The NMR data are consistent with literature reports.

References

[1] Patent: WO2012/95628, 2012, A1. Location in patent: Page/Page column 18-19
[2] Patent: WO2006/117549, 2006, A1. Location in patent: Page/Page column 148
[3] Patent: WO2005/12280, 2005, A1. Location in patent: Page/Page column 53
[4] Patent: WO2006/12135, 2006, A1. Location in patent: Page/Page column 49-51
[5] Patent: US2006/293379, 2006, A1. Location in patent: Page/Page column 63

TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATE Suppliers

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View Lastest Price from TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATE manufacturers

Career Henan Chemical Co
Product
TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATE 156866-52-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-31

156866-52-3, TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATERelated Search:

TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATE tert-butyl n-(3-formylbenzyl)carbamate 2-TERT-BUTYL 6-METHYL 3,4-DIHYDROISOQUINOLINE-2,6(1H)-DICARBOXYLATE 4-[(tert-Butoxycarbonylamino)methyl]benzoic acid 2-(TERT-BUTOXYCARBONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-6-CARBOXYLIC ACID 2-(TERT-BUTOXYCARBONYL)ISOINDOLINE-5-CARBOXYLIC ACID 2-(4-CARBOXY-PHENYL)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER [4-(2-P-TOLYL-ACETYL)-BENZYL]-CARBAMIC ACID TERT-BUTYL ESTER (4-PHENYLACETYL-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER 4-(1-(TERT-BUTOXYCARBONYL)PIPERIDIN-2-YL)BENZOIC ACID 4-(T-BOC-AMINOMETHYL)-3-CHLOROBENZOIC ACID (4-[2-(4-CHLORO-PHENYL)-ACETYL]-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER (4-[2-(4-METHOXY-PHENYL)-ACETYL]-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER 4-(BOC-AMIDINO)-BENZOIC ACID (4-[2-(4-FLUORO-PHENYL)-ACETYL]-BENZYL)-CARBAMIC ACID TERT-BUTYL ESTER AKOS BBS-00002797 FMOC-LYS-6-N-[4-BOC-AMINOMETHYL-4-(1,2:3,4 DIISOPROPYLIDEN-6-MERCAPTO-ALPHA-D-GALACTOSYL) BENZOYL-AMINO]-OH RARECHEM AL BO 1195

  • 4-(N-TERTBUTOXYAMINOMETHYL)BENZALDEHYDE
  • TERT-BUTYL N-(4-FORMYLBENZYL)CARBAMATE
  • 4-(Aminomethyl)benzaldehyde, N-BOC protected
  • Tert-butylN-[(4-formylphenyl)methyl]carbamate
  • tert-butyl 4-formylbenzylcarbamate
  • tert-Butyl (4-formylbenzyl)carbamate, 4-{[(tert-Butoxycarbonyl)amino]methyl}benzaldehyde
  • CarbaMic acid, [(4-forMylphenyl)Methyl]-, 1,1-diMethylethyl ester
  • (4-Formylbenzyl)carbamic acid tert-butyl ester
  • tert-Butyl (4-formylbenzyl)carbamate, 4-{[(tert-Bu
  • N-Boc-4-(Aminomethyl)benzaldehyde
  • 4-[(Boc-amino)methyl]benzaldehyde
  • (4-formyl-benzyl)-carbamic acid t-butyl ester
  • Carbamic acid, N-[(4-formylphenyl)methyl]-, 1,1-dimethylethyl ester
  • 156866-52-3