3-BROMO-PYRAZOLO[1,5-A]PYRIDINE
- Product Name
- 3-BROMO-PYRAZOLO[1,5-A]PYRIDINE
- CAS No.
- 5910-12-3
- Chemical Name
- 3-BROMO-PYRAZOLO[1,5-A]PYRIDINE
- Synonyms
- 3-broMoH-pyrazolo[1,5-a]pyridine;3-Brompyrazolo[1,5-a]pyridin;3-BROMO-PYRAZOLO[1,5-A]PYRIDINE;3-bromopyrazolo[1,5-a]pyridine(SALTDATA: FREE)
- CBNumber
- CB1451252
- Molecular Formula
- C7H5BrN2
- Formula Weight
- 197.03
- MOL File
- 5910-12-3.mol
3-BROMO-PYRAZOLO[1,5-A]PYRIDINE Property
- Melting point:
- 55 °C(Solv: ligroine (8032-32-4))
- Density
- 1.69±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 0.56±0.30(Predicted)
- Appearance
- Off-white to gray Solid
- InChI
- InChI=1S/C7H5BrN2/c8-6-5-9-10-4-2-1-3-7(6)10/h1-5H
- InChIKey
- NMPZEHJXHWTZNI-UHFFFAOYSA-N
- SMILES
- C12=C(Br)C=NN1C=CC=C2
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B687033
- Product name
- 3-Bromo-pyrazolo[1,5-a]pyridine
- Packaging
- 50mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FB51515
- Product name
- 3-Bromo-pyrazolo[1,5-a]pyridine
- Packaging
- 25mg
- Price
- $74.5
- Updated
- 2021/12/16
- Product number
- FB51515
- Product name
- 3-Bromo-pyrazolo[1,5-a]pyridine
- Packaging
- 50mg
- Price
- $149
- Updated
- 2021/12/16
- Product number
- FB51515
- Product name
- 3-Bromo-pyrazolo[1,5-a]pyridine
- Packaging
- 100mg
- Price
- $238
- Updated
- 2021/12/16
- Product number
- OR346595
- Product name
- 3-Bromo-pyrazolo[1,5-a]pyridine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $253
- Updated
- 2021/12/16
3-BROMO-PYRAZOLO[1,5-A]PYRIDINE Chemical Properties,Usage,Production
Uses
3-Bromopyrazolo[1,5-a]pyridine is used as a pharmaceutical intermediate compound for the preparation of Hpk1 antagonists.
Synthesis
16205-46-2
5910-12-3
The general procedure for the synthesis of 3-bromopyrazolo[1,5-a]pyridine-3-carboxylic acid from pyrazolo[1,5-a]pyridine was as follows: N-bromosuccinimide (3.06 g, 17.22 mmol) and sodium bicarbonate (4.34 g, 51.66 mmol) were sequentially added to a N,N-dimethylformamide (40 mL) solution of pyrazolo[1,5-a]pyridine-3-carboxylic acid (2.81 g, 17.22 mmol) in a solution of N,N-dimethylformamide (40 mL). The reaction mixture was stirred at room temperature for 4 h and then poured into water (100 mL). The resulting suspension was extracted twice with ethyl acetate and the organic layers were combined and dried over anhydrous magnesium sulfate. After filtration, the solvent was removed by concentration under reduced pressure. The crude product was purified by fast column chromatography (eluent: hexane/ethyl acetate = 8:2) to afford the target product 3-bromopyrazolo[1,5-a]pyridine (2.58 g, 76% yield). Mass spectrum (LRMS) showed m/z: 197 ([M+1]+). 1H-NMR (250 MHz, CDCl3) δ: 6.8 (t, 1H), 7.2 (t, 1H), 7.5 (d, 1H), 7.9 (s, 1H), 8.4 (d, 1H).
References
[1] Patent: WO2011/101161, 2011, A1. Location in patent: Page/Page column 99
3-BROMO-PYRAZOLO[1,5-A]PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
3-BROMO-PYRAZOLO[1,5-A]PYRIDINE Suppliers
- Tel
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- Fax
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- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
- Tel
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- Fax
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- info@keyorganics.net
- Country
- United Kingdom
- ProdList
- 6741
- Advantage
- 50
View Lastest Price from 3-BROMO-PYRAZOLO[1,5-A]PYRIDINE manufacturers
- Product
- 3-BROMO-PYRAZOLO[1,5-A]PYRIDINE 5910-12-3
- Price
- US $3.00/ASSAYS
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-09