5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE

Product Name: 5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE
CAS No.: 175205-09-1
Chemical Name: 5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE
Synonyms: Activator 42;KG-548;KG-548 (KG548);BUTTPARK 1\01-72;Activator 42(R) 0.1 M;Activator 42^?;5-[3,5-Bis(trifluoromethyl)phenyl]-1H-tetra;5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE;5-[3,5-Bis(trifluoromethyl)phenyl]tetrazole97%;5-[3,5-bis(trifluoromethyl)phenyl]-2H-tetrazole
CBNumber: CB1454172
Molecular Formula: C9H4F6N4
Formula Weight: 282.15
MOL File: 175205-09-1.mol

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5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE Property

Melting point:: 177-180°C
Boiling point:: 298.2±50.0 °C(Predicted)
Density: 1.569±0.06 g/cm3(Predicted)
Flash point:: 5℃
storage temp.: Sealed in dry,2-8°C
solubility: DMSO: soluble20mg/mL, clear
pka: 3.59±0.10(Predicted)
form: powder
color: white to beige
CAS DataBase Reference: 175205-09-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,T
Risk Statements: 25-36/37/38
Safety Statements: 26-45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
Hazard Note: Irritant

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: L031000
Product name: Activator 42®
Purity: 0.1 M
Packaging: 6X450ML
Price: $558
Updated: 2025/07/31

Sigma-Aldrich

Product number: L031100
Product name: KG-548
Purity: 70-77 g/L (Activator 42 content, titration)
Packaging: 6x450ml
Price: $541
Updated: 2025/07/31

Sigma-Aldrich

Product number: L031100
Product name: KG-548
Purity: 70-77 g/L (Activator 42 content, titration)
Packaging: 10l
Price: $1310
Updated: 2025/07/31

Sigma-Aldrich

Product number: L031100
Product name: KG-548
Purity: 70-77 g/L (Activator 42 content, titration)
Packaging: 4x2.5l
Price: $1310
Updated: 2025/07/31

Sigma-Aldrich

Product number: L031180
Product name: KG-548
Purity: 70-77 g/L (Activator 42 content, titration)
Packaging: 6x200ml
Price: $235
Updated: 2025/07/31

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5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE Chemical Properties,Usage,Production

Uses

KG-548 is an ARNT/TACC3 disruptor and a HIF-1α inhibitor. KG-548 directly interferes with ARNT/TACC3 complex formation by competing with TACC3 for binding to the ARNT PAS-B domain. ARNT is the aryl hydrocarbon receptor nuclear translocator, also known as HIF-β[1][2].

References

[1] Guo Y, et al. Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules. ACS Chem Biol. 2013 Mar 15;8(3):626-35. DOI:10.1021/cb300604u
[2] Kleszcz R, et al. The inhibition of c-MYC transcription factor modulates the expression of glycolytic and glutaminolytic enzymes in FaDu hypopharyngeal carcinoma cells. Adv Clin Exp Med. 2018 Jun;27(6):735-742. DOI:10.17219/acem/68979

5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE Suppliers

China 39 Germany 2 India 3 United Kingdom 7 United States 10 Global 61

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175205-09-1, 5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLERelated Search:

Trifluoromethanesulfonimide BUTTPARK 44\01-39 BUTTPARK 1\01-79 N'1-(2-CHLOROACETYL)-2-(5-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-2H-1,2,3,4-TETRAAZOL-2-YL)PROPANOHYDRAZIDE BUTTPARK 1\01-77 BUTTPARK 1\01-74 BUTTPARK 1\01-73 BUTTPARK 17\01-53 BUTTPARK 1\01-86 BUTTPARK 1\01-78 2-([5-[(2,6-DICHLOROBENZYL)THIO]-4-(3,4-DICHLOROPHENYL)-4H-1,2,4-TRIAZOL-3-YL]METHYL)-5-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-2H-1,2,3,4-TETRAAZOLE 5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE BUTTPARK 1\01-81 BUTTPARK 1\01-87

BUTTPARK 1\01-72

5-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-2H-1,2,3,4-TETRAAZOLE

5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]TETRAZOLE

5-[3,5-Bis(trifluoromethyl)phenyl]tetrazole 97%

5-[3,5-Bis(trifluoromethyl)phenyl]tetrazole97%

5-[3,5-Bis(trifluoromethyl)phenyl]-1H-tetrazole

5-[3,5-Bis(trifluoromethyl)phenyl]-1H-tetrazole 97%

KG-548

5-[3,5-bis(trifluoromethyl)phenyl]-2H-tetrazole

5-[3,5-Bis(trifluoromethyl)phenyl]-1H-tetra

5-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-2H-1,2,3,4-TETRAZOLE

Activator 42

KG-548 (KG548)

2H-Tetrazole, 5-[3,5-bis(trifluoromethyl)phenyl]-

Activator 42(R) 0.1 M

Activator 42<sup>?</sup>

175205-09-1

C8H4F6N4

C9H4F6N4