ZL0420

Product Name: ZL0420
CAS No.: 2229039-45-4
Chemical Name: ZL0420
Synonyms: ZL0420;CS-2832;(E/Z)-ZL0420;ZL 0420;ZL-0420;ZL0420, 10 mM in DMSO;ZL 0420 ;ZL0420 ;ZL-0420;6-((2-Amino-4-hydroxy-5-methylphenyl)diazenyl)-3,4-dihydroquinolin-2(1H)-one;2(1H)-Quinolinone, 6-[2-(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-3,4-dihydro-;inhibit,Epigenetic Reader Domain,(E/Z)-ZL0420,BRD4,airway inflammation,immune response genes,ZL0420,BET,ZL-0420,bromodomains,Inhibitor
CBNumber: CB14668702
Molecular Formula: C16H16N4O2
Formula Weight: 296.32
MOL File: 2229039-45-4.mol

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ZL0420 Property

Boiling point:: 645.9±55.0 °C(Predicted)
Density: 1.41±0.1 g/cm3(Predicted)
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:9): 0.1 mg/ml
form: A crystalline solid
pka: 9.20±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

Crysdot

Product number: CD31005003
Product name: ZL0420
Purity: 98%
Packaging: 5mg
Price: $94
Updated: 2021/12/16

Crysdot

Product number: CD31005003
Product name: ZL0420
Purity: 98%
Packaging: 10mg
Price: $175
Updated: 2021/12/16

Crysdot

Product number: CD31005003
Product name: ZL0420
Purity: 98%
Packaging: 25mg
Price: $299
Updated: 2021/12/16

DC Chemicals

Product number: DC11261
Product name: ZL0420
Purity: >98%
Packaging: 100mg
Price: $750
Updated: 2021/12/16

DC Chemicals

Product number: DC11261
Product name: ZL0420
Purity: >98%
Packaging: 1g
Price: $2300
Updated: 2021/12/16

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ZL0420 Chemical Properties,Usage,Production

Description

ZL0420 is a potent and selective BRD4 inhibitor. ZL0420 reduces airway inflammation and inhibits the TLR3-dependent innate immune gene program, including ISG54, ISG56, IL-8, and Groβ genes in cultured human small airway epithelial cells (hSAECs).

Uses

(E/Z)-ZL0420 is a racemic compound of (Z)-ZL0420 and (E)-ZL0420 isomers. (E)-ZL0420 is a potent and selective bromodomain-containing protein 4 (BRD4) inhibitor with IC50 values of 27 nM against BRD4 BD1 and 32 nM against BRD4 BD2[1].

References

[1] Zhiqing Liu, et al. Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation. Eur J Med Chem. 2018 May 10;151:450-461. DOI:10.1016/j.ejmech.2018.04.006

ZL0420 Preparation Products And Raw materials

Raw materials

Preparation Products

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ZL0420 Suppliers

China 52 India 1 United States 7 Global 60

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
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Shanghaizehan biopharma technology co., Ltd.

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BOC Sciences

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ShangHai Biochempartner Co.,Ltd

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Shanghai Rechem science Co., Ltd.

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Shanghai Chaolan Chemical Technology Center

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Chuzhou KeMail Chemical Technology Co., Ltd

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Heze Development Zone chuangli Chemical Co., Ltd.

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2229039-45-4, ZL0420Related Search:

ZLN005 ZL0454 4-((3,5-Dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoic acid

ZL0420

CS-2832

ZL 0420 ;ZL0420 ;ZL-0420

ZL 0420;ZL-0420

2(1H)-Quinolinone, 6-[2-(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-3,4-dihydro-

inhibit,Epigenetic Reader Domain,(E/Z)-ZL0420,BRD4,airway inflammation,immune response genes,ZL0420,BET,ZL-0420,bromodomains,Inhibitor

6-((2-Amino-4-hydroxy-5-methylphenyl)diazenyl)-3,4-dihydroquinolin-2(1H)-one

(E/Z)-ZL0420

ZL0420, 10 mM in DMSO

2229039-45-4