4-((3,5-Dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoic acid

Product Name: 4-((3,5-Dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoic acid
CAS No.: 1181226-02-7
Chemical Name: 4-((3,5-Dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoic acid
Synonyms: ZL006;ZL 006;ZL006;ZL006, 10 mM in DMSO;4-((3,5-Dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoic acid;4-{[(3,5-dichloro-2-hydroxyphenyl)methyl]amino}-2-hydroxybenzoic acid;Benzoic acid, 4-[[(3,5-dichloro-2-hydroxyphenyl)methyl]amino]-2-hydroxy-;iGluR,Ionotropic glutamate receptors,ZL006,ZL-006,Inhibitor,inhibit,ZL 006
CBNumber: CB42750480
Molecular Formula: C14H11Cl2NO4
Formula Weight: 328.15
MOL File: 1181226-02-7.mol

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4-((3,5-Dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoic acid Property

Boiling point:: 530.4±50.0 °C(Predicted)
Density: 1.617±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ≥5mg/mL (warmed to 60° C)
pka: 3.40±0.10(Predicted)
form: powder
color: white to tan

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-50
Safety Statements: 61
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0146
Product name: ZL006
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $102
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0146
Product name: ZL006
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $394
Updated: 2025/07/31

Axon Medchem

Product number: Axon2878
Product name: ZL006
Purity: 99%
Packaging: 50mg
Price: $423.5
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611630
Product name: ZL-006
Packaging: 100mg
Price: $510
Updated: 2021/12/16

ChemScene

Product number: CS-5881
Product name: ZL006
Purity: 99.57%
Packaging: 100mg
Price: $672
Updated: 2021/12/16

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4-((3,5-Dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoic acid Chemical Properties,Usage,Production

Uses

ZL006 is a potent inhibitor of nNOS/PSD-95 interaction, and inhibits NMDA receptor-mediated NO synthesis.

Biochem/physiol Actions

ZL006 inhibits the ischemia-induced interaction of nNOS with postsynaptic density protein-95 (PSD-95), preventing glutamate-induced excitotoxicity and cerebral ischemic damage. It does not inhibit nNOS itself. ZL006 is brain penetrant, and has been tested in both rat and mouse models of stroke.

in vivo

Compared with P-LPs/ZL006 and free ZL006, T7-P-LPs/ZL006 exhibits a significant increase of drug accumulation in the brain tissue due to its better brain targeting delivery. Compared with free ZL006, P-LPs/ZL006 and T7-P-LPs/ZL006 exhibit a significant decrease of drug accumulation in the liver and kidney^[1].

IC 50

NMDA Receptor

References

[1] Wang Z, et al. Enhanced anti-ischemic stroke of ZL006 by T7-conjugated PEGylated liposomes drug delivery system. Sci Rep. 2015 Jul 29;5:12651. DOI:10.1038/srep12651
[2] Bach A, et al. Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions. Sci Rep. 2015 Jul 16;5:12157. DOI:10.1038/srep12157

4-((3,5-Dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-((3,5-Dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoic acid Suppliers

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4-((3,5-Dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoic acid

ZL006

ZL 006;ZL006

Benzoic acid, 4-[[(3,5-dichloro-2-hydroxyphenyl)methyl]amino]-2-hydroxy-

iGluR,Ionotropic glutamate receptors,ZL006,ZL-006,Inhibitor,inhibit,ZL 006

4-{[(3,5-dichloro-2-hydroxyphenyl)methyl]amino}-2-hydroxybenzoic acid

ZL006, 10 mM in DMSO

1181226-02-7