ChemicalBook > CAS DataBase List > 5-({1-[2-(2,4-dimethylphenoxy)ethyl]-2-methyl-1H-indol-3-yl}methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

5-({1-[2-(2,4-dimethylphenoxy)ethyl]-2-methyl-1H-indol-3-yl}methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

Product Name
5-({1-[2-(2,4-dimethylphenoxy)ethyl]-2-methyl-1H-indol-3-yl}methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
CAS No.
667880-38-8
Chemical Name
5-({1-[2-(2,4-dimethylphenoxy)ethyl]-2-methyl-1H-indol-3-yl}methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Synonyms
IAC-8;ZLDI-8, 10 mM in DMSO;5-({1-[2-(2,4-dimethylphenoxy)ethyl]-2-methyl-1H-indol-3-yl}methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione;4,6(1H,5H)-Pyrimidinedione, 5-[[1-[2-(2,4-dimethylphenoxy)ethyl]-2-methyl-1H-indol-3-yl]methylene]dihydro-2-thioxo-;pithelial-mesenchymal,ZLDI8,transition,anti-tumor,inhibit,Phosphatase,Sorafenib,E-Cadherin,N-Cadherin,Apoptosis,Notch,Survivin,ZLDI 8,Inhibitor,NICD,ADAM-17,cIAP1/2,Vimentin,ZLDI-8
CBNumber
CB32060973
Molecular Formula
C24H23N3O3S
Formula Weight
433.52
MOL File
667880-38-8.mol
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5-({1-[2-(2,4-dimethylphenoxy)ethyl]-2-methyl-1H-indol-3-yl}methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione Property

Density 
1.30±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
62.5 mg/mL in DMSO
pka
5.34±0.20(Predicted)
form 
Solid
color 
Yellow to orange
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0087510
Product name
ZLDI-8
Purity
98.53%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0087510
Product name
ZLDI-8
Purity
98.53%
Packaging
10mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0087510
Product name
ZLDI-8
Purity
98.53%
Packaging
50mg
Price
$1650
Updated
2021/12/16
ChemScene
Product number
CS-0087510
Product name
ZLDI-8
Purity
98.53%
Packaging
100mg
Price
$2250
Updated
2021/12/16
DC Chemicals
Product number
DC11017
Product name
ZLDI-8
Purity
>98%
Packaging
1g
Price
$1900
Updated
2021/12/16
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5-({1-[2-(2,4-dimethylphenoxy)ethyl]-2-methyl-1H-indol-3-yl}methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione Chemical Properties,Usage,Production

Uses

ZLDI-8 is a Notch activating/cleaving enzyme ADAM-17 inhibitor and inhibits the cleavage of Notch protein. ZLDI-8 decreases the expression of pro-survival/anti-apoptosis and epithelial-mesenchymal transition (EMT) related proteins. ZLDI-8 is also a competitive and irreversible tyrosine phosphatase (Lyp) inhibitor with an IC50 of 31.6 μM and a Ki of 26.22 μM. ZLDI-8 inhibits the growth of MHCC97-H cells with an IC50 of 5.32 μM[1][2].

in vivo

ZLDI-8 (0.2-2 mg/kg; intraperitoneal injection; every two days; for 20 days; nude mice) treatment enhances the effect of Sorafenib on inhibiting tumor growth in nude HCC-bearing mice model[1].

Animal Model:Nude mice with MHCC-97H cells[1]
Dosage:2?mg/kg, 1?mg/kg, 500?μg/kg, or 200?μg/kg
Administration:Intraperitoneal injection; every two days; for 20 days
Result: Inhibited tumor growth in nude HCC-bearing mice model.

References

[1] Zhang Y, et al. Novel ADAM-17 inhibitor ZLDI-8 enhances the in vitro and in vivo chemotherapeutic effects of Sorafenib on hepatocellular carcinoma cells. Cell Death Dis. 2018 Jul 3;9(7):743. DOI:10.1038/s41419-018-0804-6
[2] Hou X, et al. Fast identification of novel lymphoid tyrosine phosphatase inhibitors using target-ligand interaction-based virtual screening. J Med Chem. 2014 Nov 26;57(22):9309-22. DOI:10.1021/jm500692u

5-({1-[2-(2,4-dimethylphenoxy)ethyl]-2-methyl-1H-indol-3-yl}methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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5-({1-[2-(2,4-dimethylphenoxy)ethyl]-2-methyl-1H-indol-3-yl}methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione Suppliers

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667880-38-8, 5-({1-[2-(2,4-dimethylphenoxy)ethyl]-2-methyl-1H-indol-3-yl}methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dioneRelated Search:

ZLJ-6 4-((3,5-Dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoic acid ZL0580 ZL0420

  • 5-({1-[2-(2,4-dimethylphenoxy)ethyl]-2-methyl-1H-indol-3-yl}methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
  • IAC-8
  • pithelial-mesenchymal,ZLDI8,transition,anti-tumor,inhibit,Phosphatase,Sorafenib,E-Cadherin,N-Cadherin,Apoptosis,Notch,Survivin,ZLDI 8,Inhibitor,NICD,ADAM-17,cIAP1/2,Vimentin,ZLDI-8
  • 4,6(1H,5H)-Pyrimidinedione, 5-[[1-[2-(2,4-dimethylphenoxy)ethyl]-2-methyl-1H-indol-3-yl]methylene]dihydro-2-thioxo-
  • ZLDI-8, 10 mM in DMSO
  • 667880-38-8