ZL0580

Product Name: ZL0580
CAS No.: 2377151-10-3
Chemical Name: ZL0580
Synonyms: ZL0580;ZL0580, 10 mM in DMSO;(S)-N-Phenyl-1-((4-(3-(4-(trifluoromethyl)phenyl)ureido)phenyl)sulfonyl)pyrrolidine-2-carboxamide;2-Pyrrolidinecarboxamide, N-phenyl-1-[[4-[[[[4-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]sulfonyl]-, (2S)-;ZL0580,HIV,ZL-0580,Inhibitor,Human immunodeficiency virus,low,ZL 0580,inhibit,PBMC,toxicity,Epigenetic Reader Domain
CBNumber: CB36187861
Molecular Formula: C25H23F3N4O4S
Formula Weight: 532.53
MOL File: 2377151-10-3.mol

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ZL0580 Property

Density: 1.481±0.06 g/cm3(Predicted)
pka: 13.38±0.70(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0103864
Product name: ZL0580
Purity: 99.48%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0103864
Product name: ZL0580
Purity: 99.48%
Packaging: 10mg
Price: $580
Updated: 2021/12/16

ChemScene

Product number: CS-0103864
Product name: ZL0580
Purity: 99.48%
Packaging: 50mg
Price: $1550
Updated: 2021/12/16

ChemScene

Product number: CS-0103864
Product name: ZL0580
Purity: 99.48%
Packaging: 100mg
Price: $2400
Updated: 2021/12/16

ChemScene

Product number: CS-0103864
Product name: ZL0580
Purity: 99.48%
Packaging: 250mg
Price: $3600
Updated: 2021/12/16

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ZL0580 Chemical Properties,Usage,Production

Uses

ZL0580, a structurally close analog of ZL0590, induces epigenetic suppression of HIV via selectively binding to BD1 domain of BRD4. ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter[1][2][3].

IC 50

BRD4 (BD1)

References

[1] Niu Q, et al. Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV. J Clin Invest. 2019 Jul 22;129(8):3361-3373. DOI:10.1172/JCI120633
[2] Vansant G, et al. Block-And-Lock Strategies to Cure HIV Infection. Viruses. 2020 Jan 10;12(1). pii: E84. DOI:10.3390/v12010084
[3] Brasier AR, et al. Validation of the epigenetic reader bromodomain-containing protein 4 (BRD4) as a therapeutic target for treatment of airway remodeling. Drug Discov Today. 2020 Jan;25(1):126-132. DOI:10.1016/j.drudis.2019.11.002

ZL0580 Preparation Products And Raw materials

Raw materials

Preparation Products

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ZL0580 Suppliers

China 18 United States 1 Global 19

Shanghai Beckham Medical Technology Co., Ltd

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Hangzhou ChangCun Biotechnology Co., Ltd.

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Beijing Solarbio Science & Tecnology Co., Ltd.

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TargetMol Chemicals Inc.

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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cjbscvictory

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TargetMol Chemicals Inc.

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Shanghai Yifei Biotechnology Co. , Ltd.

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Shanghai?Medlife?Pharm-Tech?Co.,?Ltd

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Nanjing Shizhou Biology Technology Co.,Ltd

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2377151-10-3, ZL0580Related Search:

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ZL0580

ZL0580,HIV,ZL-0580,Inhibitor,Human immunodeficiency virus,low,ZL 0580,inhibit,PBMC,toxicity,Epigenetic Reader Domain

2-Pyrrolidinecarboxamide, N-phenyl-1-[[4-[[[[4-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]sulfonyl]-, (2S)-

ZL0580, 10 mM in DMSO

(S)-N-Phenyl-1-((4-(3-(4-(trifluoromethyl)phenyl)ureido)phenyl)sulfonyl)pyrrolidine-2-carboxamide

2377151-10-3