ZL0420

Product Name: ZL0420
CAS No.: 2230496-80-5
Chemical Name: ZL0420
Synonyms: (E)-ZL0420;2(1H)-Quinolinone, 6-[(1E)-2-(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-3,4-dihydro-;6-[(1E)-2-(2-amino-4-hydroxy-5-methylphenyl)diazen-1-yl]-1,2,3,4-tetrahydroquinolin-2-one
CBNumber: CB04845074
Molecular Formula: C16H16N4O2
Formula Weight: 296.32
MOL File: 2230496-80-5.mol

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ZL0420 Property

Boiling point:: 645.9±55.0 °C(Predicted)
Density: 1.41±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:9): 0.1 mg/ml
form: Solid
pka: 9.56±0.36(Predicted)
color: Yellow to orange

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0043492
Product name: ZL0420
Purity: >98.0%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-0043492
Product name: ZL0420
Purity: >98.0%
Packaging: 10mg
Price: $210
Updated: 2021/12/16

ChemScene

Product number: CS-0043492
Product name: ZL0420
Purity: >98.0%
Packaging: 25mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-0043492
Product name: ZL0420
Purity: >98.0%
Packaging: 50mg
Price: $720
Updated: 2021/12/16

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ZL0420 Chemical Properties,Usage,Production

Uses

ZL0420 is a potent and selective bromodomain-containing protein 4 (BRD4) inhibitor with IC50 values of 27 nM against BRD4 BD1 and 32 nM against BRD4 BD2.

in vivo

ZL0420 demonstrates potent efficacy reducing airway inflammation in a mouse model with low toxicity. ZL0420 displays high efficacy and almost completely blocks the profound accumulation of neutrophils around the small and medium sized airways induced by poly(I:C) administration^[1].

References

[1] Liu Z, et al. Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation. Eur J Med Chem. 2018 May 10;151:450-461. DOI:10.1016/j.ejmech.2018.04.006

ZL0420 Preparation Products And Raw materials

Raw materials

Preparation Products

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ZL0420 Suppliers

China 13 Global 13

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
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Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
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ProdList: 9729
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
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Shanghai hongqu biomedical technology co. LTD

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Email: hongquchem@qq.com
Country: China
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Zhengzhou convergence chemical co., LTD

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Meryer (Shanghai) Chemical Technology Co., Ltd.

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https://hanhongsci.com/

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RD International Technology Co., Limited

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Shanghai Macklin Biochemical Co.,Ltd.

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Biosynth Biological Technology (Suzhou) Co Ltd

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Email: sales@biosynth.com
Country: China
ProdList: 6051
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2230496-80-5, ZL0420Related Search:

ZLJ-6 4-((3,5-Dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoic acid ZL0580 5-({1-[2-(2,4-dimethylphenoxy)ethyl]-2-methyl-1H-indol-3-yl}methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

2(1H)-Quinolinone, 6-[(1E)-2-(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-3,4-dihydro-

6-[(1E)-2-(2-amino-4-hydroxy-5-methylphenyl)diazen-1-yl]-1,2,3,4-tetrahydroquinolin-2-one

(E)-ZL0420

2230496-80-5