ZL0454

Product Name: ZL0454
CAS No.: 2229042-77-5
Chemical Name: ZL0454
Synonyms: ZL0454;ZL0454,ZL-0454;Benzenesulfonamide, 4-[(1E)-2-(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-N-cyclopentyl-
CBNumber: CB44668703
Molecular Formula: C18H22N4O3S
Formula Weight: 374.46
MOL File: 2229042-77-5.mol

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ZL0454 Property

Boiling point:: 630.6±65.0 °C(Predicted)
Density: 1.41±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 50 mg/mL (133.53 mM; Need ultrasonic)
pka: 9.30±0.36(Predicted)
form: Solid
color: Brown to reddish brown

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Hazard and Precautionary Statements (GHS)

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ZL0454 Chemical Properties,Usage,Production

Biological Activity

ZL0454 is a potent and selective Bromodomain-containing protein 4 (BRD4) inhibitor with an IC50 of 49 and 32 nM for BD1 and BD2.

References

[1]. Liu Z, et al. Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation. Eur J Med Chem. 2018 May 10;151:450-461.

ZL0454 Preparation Products And Raw materials

Raw materials

Preparation Products

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ZL0454 Suppliers

China 7 United States 3 Global 10

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
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TargetMol Chemicals Inc.

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InvivoChem

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cjbscvictory

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InvivoChem

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TargetMol Chemicals Inc.

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Shanghai Yifei Biotechnology Co. , Ltd.

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Nanjing Shizhou Biology Technology Co.,Ltd

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RD International Technology Co., Limited

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TargetMol Chemicals Inc.

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Benzenesulfonamide, 4-[(1E)-2-(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-N-cyclopentyl-

2229042-77-5