tert-Butyl 2-(methylamino)ethylcarbamate

Uses

Product Name: tert-Butyl 2-(methylamino)ethylcarbamate
CAS No.: 122734-32-1
Chemical Name: tert-Butyl 2-(methylamino)ethylcarbamate
Synonyms: BUTTPARK 90\06-21;1-BOC-AMINO-2-METHYLAMINO-ETHANE;Boc-2-(Methylamino)ethylcarbamate;2-N-Boc-N1-methylethane-1,2-diamine;N-Boc-2-methylamino-ethylamine, 98%;1-Boc-Amino-2-methylamino-ethane ,98%;ert-Butyl2-(methylamino)ethylcarbamate;tert-Butyl 2-(methylamino)ethylcarbamat;TERT-BUTYL 2-(METHYLAMINO)ETHYLCARBAMATE;1-BOC-Amino-2-methylamino-ethane(HClform)
CBNumber: CB1467116
Molecular Formula: C8H18N2O2
Formula Weight: 174.24
MOL File: 122734-32-1.mol

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tert-Butyl 2-(methylamino)ethylcarbamate Property

Melting point:: 35 °C
Boiling point:: 260.1±23.0 °C(Predicted)
Density: 0.958±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to lump
pka: 12?+-.0.46(Predicted)
color: White to Almost white
InChI: InChI=1S/C8H18N2O2/c1-8(2,3)12-7(11)10-6-5-9-4/h9H,5-6H2,1-4H3,(H,10,11)
InChIKey: GKWGBMHXVRSFRT-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NCCNC
CAS DataBase Reference: 122734-32-1

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
HS Code: 2921490090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B4046
Product name: N-(tert-Butoxycarbonyl)-N'-methylethylenediamine
Purity: >98.0%(T)
Packaging: 1g
Price: $43
Updated: 2025/07/31

TCI Chemical

Product number: B4046
Product name: N-(tert-Butoxycarbonyl)-N'-methylethylenediamine
Purity: >98.0%(T)
Packaging: 5g
Price: $128
Updated: 2025/07/31

TRC

Product number: B809538
Product name: tert-Butyl2-(methylamino)ethylcarbamate
Packaging: 500mg
Price: $75
Updated: 2021/12/16

ChemScene

Product number: CS-W008686
Product name: tert-ButylN-[2-(methylamino)ethyl]carbamate
Purity: 98.86%
Packaging: 5g
Price: $17
Updated: 2021/12/16

Matrix Scientific

Product number: 073322
Product name: tert-Butyl 2-(methylamino)ethylcarbamate
Purity: 95+%
Packaging: 1g
Price: $20
Updated: 2021/12/16

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tert-Butyl 2-(methylamino)ethylcarbamate Chemical Properties,Usage,Production

Uses

2-(methylamino)ethylcarbamate tert-butyl ester was used in the study of hydrophilic derivatives of the antibody-drug conjugate gentamicin.

Chemical Properties

White to very pale yellow solid

Synthesis

849472-99-7

122734-32-1

General procedure for the synthesis of tert-butyl 2-(methylamino)ethyl carbamate from (2-(benzyl(methyl)amino)ethyl)carbamate: 1. To a reaction flask were added 20% Pd(OH)2/carbon catalyst (3.1 g), tert-butyl (2-(benzyl(methyl)amino)ethyl)carbamate (3.3 g, 12.5 mmol), methanol (200 mL) and water (2 mL). 2. The reaction system was placed under a hydrogen atmosphere (40 psi) for 2.5 hours. 3. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth and concentrated under vacuum to remove the solvent. 4. Water (50 mL) was added to the concentrate and the pH was adjusted to 12 with alkali. 5. The aqueous phase was extracted with dichloromethane (3 x 50 mL) and the organic layers were combined. 6. The organic layer was dried with anhydrous magnesium sulfate, filtered and concentrated in vacuum to give tert-butyl 2-(methylamino)ethylcarbamate (2.0 g, 11.7 mmol, 94% yield) as a colorless oil. LC-MS [M + H] 686.5 (C35H51N5O7S + H, calculated value: 685.9).

References

[1] Patent: US2011/262355, 2011, A1. Location in patent: Page/Page column 136
[2] Patent: WO2011/133149, 2011, A1. Location in patent: Page/Page column 298
[3] Patent: WO2011/133150, 2011, A1. Location in patent: Page/Page column 300
[4] Patent: JP2016/41698, 2016, A. Location in patent: Paragraph 0364; 0377
[5] Patent: US2010/41748, 2010, A1. Location in patent: Page/Page column 120

tert-Butyl 2-(methylamino)ethylcarbamate Preparation Products And Raw materials

Raw materials

N-METHYLETHYLENEDIAMINE 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

Preparation Products

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tert-Butyl 2-(methylamino)ethylcarbamate Suppliers

Americas 1 China 157 Europe 4 France 1 India 2 Japan 1 United Kingdom 3 United States 16 Global 185

Suzhou Highfine Biotech Co., Ltd

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View Lastest Price from tert-Butyl 2-(methylamino)ethylcarbamate manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: tert-Butyl 2-(methylamino)ethylcarbamate 122734-32-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-17

Zhuozhou Wenxi import and Export Co., Ltd

Product: tert-Butyl 2-(methylamino)ethylcarbamate 122734-32-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: tert-Butyl 2-(methylamino)ethylcarbamate 122734-32-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

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TERT-BUTYL 2-(METHYLAMINO)ETHYLCARBAMATE

Boc-2-(Methylamino)ethylcarbamate

Carbamic acid, [2-(methylamino)ethyl]-, 1,1-dimethylethyl ester (9CI)

N-(tert-Butoxycarbonyl)-N-methylethylenediamine

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1-BOC-Amino-2-methylamino-ethane(HClform)

1-Boc-Amino-2-methylamino-ethane ,98%

1-BOC-AMINO-2-METHYLAMINO-ETHANE

BUTTPARK 90\06-21

[2-(methylamino)ethyl]-, 1,1-dimethylethyl ester (9CI)

2-N-Boc-N1-methylethane-1,2-diamine

N-(tert-Butoxycarbonyl)-N'-methylethylenediamine

N-(tert-Butoxycarbonyl)-N'-methylethylenediamine≥ 98%(Titration)

tert-butyl N-[2-(MethylaMino)ethyl]carbaMate

N-Boc-2-methylamino-ethylamine, 98%

N-[2-(methylamino)ethyl]carbamic acid tert-butyl ester

N-(tert-Butoxycarbonyl)-N'-methylethylenediamine &gt

Carbamic acid, N-[2-(methylamino)ethyl]-, 1,1-dimethylethyl ester

tert-Butyl 2-(methylamino)ethylcarbamat

ert-Butyl2-(methylamino)ethylcarbamate

1,1-Dimethylethyl N-[2-(methylamino)ethyl]carbamate

N-(tert-Butoxycarbonyl)-N'-methylethylenediamine

122734-32-1

N-BOC