CFM 4

Product Name: CFM 4
CAS No.: 331458-02-7
Chemical Name: CFM 4
Synonyms: CFM 4;1-[(2-Chlorophenyl)methyl]-5'-phenyl-spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one;Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 1-[(2-chlorophenyl)methyl]-5'-phenyl-
CBNumber: CB14718599
Molecular Formula: C22H16ClN3OS
Formula Weight: 405.9
MOL File: 331458-02-7.mol

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CFM 4 Property

Boiling point:: 653.4±65.0 °C(Predicted)
Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (greater than 25 mg/ml)
form: solid
pka: 0.13±0.20(Predicted)
color: Tan
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 5144
Product name: CFM4
Purity: ≥99%(HPLC)
Packaging: 10
Price: $156
Updated: 2021/12/16

Tocris

Product number: 5144
Product name: CFM4
Purity: ≥99%(HPLC)
Packaging: 50
Price: $648
Updated: 2021/12/16

TRC

Product number: C291738
Product name: CFM4
Packaging: 5mg
Price: $385
Updated: 2021/12/16

Usbiological

Product number: 254924
Product name: CFM 4
Packaging: 10mg
Price: $452
Updated: 2021/12/16

ApexBio Technology

Product number: B7760
Product name: CFM4
Packaging: 10mg
Price: $308
Updated: 2021/12/16

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CFM 4 Chemical Properties,Usage,Production

Description

CFM-4 (331458-02-7) is a CARP-1 functional mimetic that interferes with CARP-1 binding to APC-2 (IC50=10-15 μM).1 Enhances CARP-1 expression and induces G2/M cell cycle arrest. Induces apoptosis and suppresses growth of medulloblastoma cells2 and malignant pleural mesothelioma cells3.

References

1) Puliyappadamba et al. (2011), Antagonists of anaphase-promoting complex (APC)-2-cell cycle and apoptosis regulatory protein (CARP)-1 interaction are novel regulators of cell growth and apoptosis; J. Biol. Chem. 286 38000 2) Ashour et al. (2013), CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth; PLoS ONE 8 e66733 3) Jamal et al. (2014), CARP-1 functional mimetics are a novel class of small molecule inhibitors of malignant pleural mesothelioma cells; PLoS ONE 9 e89146

CFM 4 Preparation Products And Raw materials

Raw materials

Preparation Products

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CFM 4 Suppliers

China 8 United Kingdom 1 United States 5 USA 1 Global 15

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 4418
Advantage: 55

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24647
Advantage: 58

Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 11974
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: +86-18521732826
Email: market@aladdin-e.com
Country: China
ProdList: 48461
Advantage: 58

Shanghai Haoyang Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 596799915@QQ.COM
Country: CHINA
ProdList: 2905
Advantage: 58

Shanghai Weiwei Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: sales@wheybio.com
Country: CHINA
ProdList: 4398
Advantage: 58

Beijing Bolide Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1985563437@qq.com
Country: CHINA
ProdList: 6158
Advantage: 58

331458-02-7, CFM 4Related Search:

3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone (S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate NUTLIN-3 BML-259

CFM 4

1-[(2-Chlorophenyl)methyl]-5'-phenyl-spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one

Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 1-[(2-chlorophenyl)methyl]-5'-phenyl-

331458-02-7