BML-259
- Product Name
- BML-259
- CAS No.
- 267654-00-2
- Chemical Name
- BML-259
- Synonyms
- BML-259;CAY10554;BML-259, 10 mM in DMSO;N-(5-Isopropylthiazol-2-yl)-2-phenylacetamide;Benzeneacetamide, N-[5-(1-methylethyl)-2-thiazolyl]-;2-phenyl-N-(5-propan-2-yl-1,3-thiazol-2-yl)acetamide;BML-259,protein,p53,CDK,death,disease,neurotoxicity,cell,Inhibitor,inhibit,Cyclin dependent kinase,Alzheimer's
- CBNumber
- CB12450947
- Molecular Formula
- C14H16N2OS
- Formula Weight
- 260.35
- MOL File
- 267654-00-2.mol
BML-259 Property
- Melting point:
- 150-152℃
- storage temp.
- RT
- solubility
- Soluble in DMSO (up to 25 mg/ml).
- form
- White solid.
- color
- white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety
- WGK Germany
- WGK 3
- Storage Class
- 11 - Combustible Solids
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- SRP0704
- Product name
- BML-259
- Purity
- recombinant
- Packaging
- 25mg
- Price
- $352
- Updated
- 2025/07/31
- Product number
- 10010301
- Product name
- CAY10554
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $64
- Updated
- 2024/03/01
- Product number
- 10010301
- Product name
- CAY10554
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $119
- Updated
- 2024/03/01
- Product number
- 10010301
- Product name
- CAY10554
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $280
- Updated
- 2024/03/01
- Product number
- 10010301
- Product name
- CAY10554
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $497
- Updated
- 2024/03/01
BML-259 Chemical Properties,Usage,Production
Description
BML-259 (267654-00-2) is a potent inhibitor of Cdk5/p25 (IC50 = 64 nM) and Cdk2 (IC50 = 98nM).1
Uses
BML-259 is a potent cyclin-dependent kinase 5 (Cdk5) inhibitor, with IC50s of 64 and 98 nM for Cdk5 and Cdk2, respectively[1].
Definition
ChEBI: 2-phenyl-N-(5-propan-2-yl-2-thiazolyl)acetamide is a member of acetamides.
References
[1] CHRISTOPHER J. HELAL. Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer’s disease[J]. Bioorganic & Medicinal Chemistry Letters, 2004, 14 22: Pages 5521-5525. DOI:10.1016/j.bmcl.2004.09.006
BML-259 Preparation Products And Raw materials
Raw materials
Preparation Products
BML-259 Suppliers
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