BUTYROLACTONE I

Product Name: BUTYROLACTONE I
CAS No.: 87414-49-1
Chemical Name: BUTYROLACTONE I
Synonyms: OloMoucin;BUTYROLACTONE I;Butyrolactone I - CAS 87414-49-1;2,5-Dihydro-4-hydroxy-2-[4-hydroxy-3-(3-methyl-2-butenyl)benzyl]-3-(4-hydroxyphenyl)-5-oxofuran-2-carboxylic acid methyl ester;2-Furancarboxylic acid, 2,5-dihydro-4-hydroxy-2-[[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]methyl]-3-(4-hydroxyphenyl)-5-oxo-, methyl ester, (2R)-
CBNumber: CB9717987
Molecular Formula: C24H24O7
Formula Weight: 424.44
MOL File: 87414-49-1.mol

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BUTYROLACTONE I Property

Melting point:: 74℃
Boiling point:: 660.1±55.0 °C(Predicted)
Density: 1.353±0.06 g/cm3(Predicted)
RTECS: LU0221600
storage temp.: Store at -20°C
solubility: Soluble in ethanol at 25mg/ml or DMSO at 10mg/ml
form: White solid.
pka: 8.59±0.40(Predicted)
color: White to off-white
Sensitive: Light Sensitive

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Safety

HS Code: 29419000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 203988
Product name: Butyrolactone I - CAS 87414-49-1 - Calbiochem
Purity: A cell-permeable and highly selective inhibitor of cyclin-dependent protein kinases (Cdks) that inhibits cell cycle progression at the G?/S and G?/M transitions.
Packaging: 200μG
Price: $251
Updated: 2023/06/20

Alfa Aesar

Product number: J67151
Product name: Butyrolactone I, 98%
Packaging: 200microg
Price: $162
Updated: 2021/12/16

Cayman Chemical

Product number: 21765
Product name: Butyrolactone I
Purity: ≥95%
Packaging: 1mg
Price: $186
Updated: 2024/03/01

Cayman Chemical

Product number: 21765
Product name: Butyrolactone I
Purity: ≥95%
Packaging: 5mg
Price: $556
Updated: 2024/03/01

TRC

Product number: B161388
Product name: ButyrolactoneI
Packaging: 200μg
Price: $90
Updated: 2021/12/16

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BUTYROLACTONE I Chemical Properties,Usage,Production

Uses

Butyrolactone I is one of a family of three butyrolactones isolated from Aspergillus fumigatus, first reported in 1983. Butyrolactone I exhibits antitumor activity, inhibiting the cell cycle at the G1/S and G2/M transitions. Butyrolactone I is a selective inhibitor of cyclin-dependent kinases CDK1/cyclin B, CDK2 and CDK5, and is an important bioprobe for understanding the cellular roles of CDKs.

Enzyme inhibitor

This natural product (FW = 424.45 g/mol), first identified in species of Aspergillus and named systematically as 2,5-dihydro-4-hydroxy 2-([4- hydroxy-3-(3-methyl-2-butenyl)phenyl]methyl)-3-(4-hydroxyphenyl)-5-oxo- 2-furancarboxylic acid methyl ester, competes with ATP in cyclindependent kinase reactions. The IC50 values for these kinases are typically 0.6-1.5 μM. Butyrolactone I also inhibits cell proliferation by the inhibiting pRb phosphorylation in IMR32 cells, causing both G1 and G2 arrest and stimulating apoptosis. Target(s): cyclin-dependent kinases 1 and 2; cdk5; protein kinase C; protein kinase A; MAP kinase; casein kinase II; [tau protein] kinase.

storage

+4°C

BUTYROLACTONE I Preparation Products And Raw materials

Raw materials

Preparation Products

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BUTYROLACTONE I Suppliers

China 19 United Kingdom 2 United States 7 Global 28

Shanghai Winherb Medical Technology Co., Ltd.

Tel: 400-400-186-5138 13341702378
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Shanghai EFE Biological Technology Co., Ltd.

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Fax: 021-65675885
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Country: China
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Lynnchem

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Country: China
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Novachemistry

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Shanghai Hongye Biotechnology Co. Ltd

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Shenzhen Polymeri Biochemical Technology Co., Ltd.

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Email: sales@rrkchem.com
Country: China
ProdList: 57412
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TargetMol Chemicals Inc.

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Email: marketing@targetmol.com
Country: United States
ProdList: 32165
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Alfa Chemistry

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Fax: 1-516-927-0118
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BOC Sciences

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
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87414-49-1, BUTYROLACTONE IRelated Search:

Roscovitine PD0332991 Isethionate PROSTAGLANDIN A2 Flavopiridol Cdk Inhibitor, p35 Palbociclib H-ALA-ASP-ALA-GLN-HIS-ALA-THR-PRO-PRO-LYS-LYS-LYS-ARG-LYS-VAL-GLU-ASP-PRO-LYS-ASP-PHE-OH NU 2058 BML-259 3-(4-Hydroxyphenyl)lactate Phenethyl cinnamate 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one 3-Hydroxy-4-methyl-5-ethyl-2(5H)furanone 2-ACETOXY-3-PHENYL-PROPIONIC ACID BUTYROLACTONE I 2,5-DIHYDRO-FURAN-2-CARBOXYLIC ACID 3-(4-HYDROXYPHENYL)-2-METHOXYPROPANOIC ACID

BUTYROLACTONE I

2,5-Dihydro-4-hydroxy-2-[4-hydroxy-3-(3-methyl-2-butenyl)benzyl]-3-(4-hydroxyphenyl)-5-oxofuran-2-carboxylic acid methyl ester

OloMoucin

2-Furancarboxylic acid, 2,5-dihydro-4-hydroxy-2-[[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]methyl]-3-(4-hydroxyphenyl)-5-oxo-, methyl ester, (2R)-

Butyrolactone I - CAS 87414-49-1

87414-49-1

Antibiotic