BUTYROLACTONE I

Product Name: BUTYROLACTONE I
CAS No.: 87414-49-1
Chemical Name: BUTYROLACTONE I
Synonyms: OloMoucin;BUTYROLACTONE I;Butyrolactone I - CAS 87414-49-1;Butyrolactone I, ATP-competitive cyclin-dependent kinase (CDK) inhibitor;2,5-Dihydro-4-hydroxy-2-[4-hydroxy-3-(3-methyl-2-butenyl)benzyl]-3-(4-hydroxyphenyl)-5-oxofuran-2-carboxylic acid methyl ester;2-Furancarboxylic acid, 2,5-dihydro-4-hydroxy-2-[[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]methyl]-3-(4-hydroxyphenyl)-5-oxo-, methyl ester, (2R)-
CBNumber: CB9717987
Molecular Formula: C24H24O7
Formula Weight: 424.44
MOL File: 87414-49-1.mol

More

Less

BUTYROLACTONE I Property

Melting point:: 74℃
Boiling point:: 660.1±55.0 °C(Predicted)
Density: 1.353±0.06 g/cm3(Predicted)
RTECS: LU0221600
storage temp.: Store at -20°C
solubility: Soluble in ethanol at 25mg/ml or DMSO at 10mg/ml
form: White solid.
pka: 8.59±0.40(Predicted)
color: White to off-white
Sensitive: Light Sensitive

More

Less

Safety

HS Code: 29419000

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 203988
Product name: Butyrolactone I - CAS 87414-49-1 - Calbiochem
Purity: A cell-permeable and highly selective inhibitor of cyclin-dependent protein kinases (Cdks) that inhibits cell cycle progression at the G?/S and G?/M transitions.
Packaging: 200μG
Price: $251
Updated: 2023/06/20

Cayman Chemical

Product number: 21765
Product name: Butyrolactone I
Purity: ≥95%
Packaging: 1mg
Price: $186
Updated: 2024/03/01

Cayman Chemical

Product number: 21765
Product name: Butyrolactone I
Purity: ≥95%
Packaging: 5mg
Price: $556
Updated: 2024/03/01

TRC

Product number: B161388
Product name: ButyrolactoneI
Packaging: 200μg
Price: $90
Updated: 2021/12/16

TRC

Product number: B161388
Product name: ButyrolactoneI
Packaging: 400μg
Price: $145
Updated: 2021/12/16

More

Less

BUTYROLACTONE I Chemical Properties,Usage,Production

Uses

Butyrolactone I is one of a family of three butyrolactones isolated from Aspergillus fumigatus, first reported in 1983. Butyrolactone I exhibits antitumor activity, inhibiting the cell cycle at the G1/S and G2/M transitions. Butyrolactone I is a selective inhibitor of cyclin-dependent kinases CDK1/cyclin B, CDK2 and CDK5, and is an important bioprobe for understanding the cellular roles of CDKs.

Biological Activity

Cell permeable: yes', 'Primary Target
p34cdk1/cyclinB', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 680 nM against Cdk1

Enzyme inhibitor

This natural product (FW = 424.45 g/mol), first identified in species of Aspergillus and named systematically as 2,5-dihydro-4-hydroxy 2-([4- hydroxy-3-(3-methyl-2-butenyl)phenyl]methyl)-3-(4-hydroxyphenyl)-5-oxo- 2-furancarboxylic acid methyl ester, competes with ATP in cyclindependent kinase reactions. The IC50 values for these kinases are typically 0.6-1.5 μM. Butyrolactone I also inhibits cell proliferation by the inhibiting pRb phosphorylation in IMR32 cells, causing both G1 and G2 arrest and stimulating apoptosis. Target(s): cyclin-dependent kinases 1 and 2; cdk5; protein kinase C; protein kinase A; MAP kinase; casein kinase II; [tau protein] kinase.

in vivo

Butyrolactone-I (1-5 mg/kg, p.o., 14 days) ameliorates heat-stress-induced apoptosis in mice through the ROS/PERK/CHOP signaling pathway^[3].
Butyrolactone-I (1-5 mg/kg, p.o., 14 days) alleviates intestinal barrier damage caused by DSS through regulating lactobacillus johnsonii and its metabolites in mice^[6].
Butyrolactone I (10-40 mg/kg, p.o., from the 17th week to 24th week) attenuates inflammation in murine NASH by inhibiting the NF-κB signaling pathway^[7].

Animal Model:	Male C57BL/6J mice (heat-stressed)^[3]
Dosage:	1, 5 mg/kg
Administration:	Oral gavage (p.o.), 14 days
Result:	Downregulated HSP70 mRNA and mitigated weight loss. Returned water intake and body temperature to normal levels. Increased colon length. Decreased Bax mRNA. Inhibited the increases in the ROS and MDA levels. Inhibited endoplasmic reticulum stress (ERS). Inhibited p-PERK/PERK, p-eIF2α/eIF2α, ATF4, and CHOP.

IC 50

CDK1

storage

+4°C

BUTYROLACTONE I Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

BUTYROLACTONE I Suppliers

China 34 United Kingdom 2 United States 8 Global 44

Shanghai Winherb Medical Technology Co., Ltd.

Tel: 021-38218169 13341702378
Fax: QQ：190129269
Email: winherb@126.com
Country: China
ProdList: 1245
Advantage: 58

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

Novachemistry

Tel: 44-20819178-90 02081917890
Fax: (0)2080432064
Email: info@novachemistry.com
Country: United Kingdom
ProdList: 4381
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Alfa Chemistry

Tel: +1-5166625404;
Fax: 1-516-927-0118
Email: Info@alfa-chemistry.com
Country: United States
ProdList: 20405
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19552
Advantage: 58

More

Less

View Lastest Price from BUTYROLACTONE I manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Butyrolactone I 87414-49-1
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-24

87414-49-1, BUTYROLACTONE IRelated Search:

Roscovitine PD0332991 Isethionate PROSTAGLANDIN A2 Flavopiridol Cdk Inhibitor, p35 Palbociclib H-ALA-ASP-ALA-GLN-HIS-ALA-THR-PRO-PRO-LYS-LYS-LYS-ARG-LYS-VAL-GLU-ASP-PRO-LYS-ASP-PHE-OH NU 2058 BML-259 3-(4-Hydroxyphenyl)lactate Phenethyl cinnamate 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one 3-Hydroxy-4-methyl-5-ethyl-2(5H)furanone 2-ACETOXY-3-PHENYL-PROPIONIC ACID BUTYROLACTONE I 2,5-DIHYDRO-FURAN-2-CARBOXYLIC ACID 3-(4-HYDROXYPHENYL)-2-METHOXYPROPANOIC ACID

BUTYROLACTONE I

2,5-Dihydro-4-hydroxy-2-[4-hydroxy-3-(3-methyl-2-butenyl)benzyl]-3-(4-hydroxyphenyl)-5-oxofuran-2-carboxylic acid methyl ester

OloMoucin

2-Furancarboxylic acid, 2,5-dihydro-4-hydroxy-2-[[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]methyl]-3-(4-hydroxyphenyl)-5-oxo-, methyl ester, (2R)-

Butyrolactone I - CAS 87414-49-1

Butyrolactone I, ATP-competitive cyclin-dependent kinase (CDK) inhibitor

87414-49-1

Antibiotic