NU 2058

Product Name: NU 2058
CAS No.: 161058-83-9
Chemical Name: NU 2058
Synonyms: CS-2601;NU2058>2-aMino-6-purine;NU 2058;NU-2058;NU2058;O-Cyclohexylmethylguanine;2-Amino-6-(cyclohexylmethoxy)purine;NU-2058;O6-(CYCLOHEXYLMETHYL)GUANINE;6-(Cyclohexylmethoxy)-9H-purin-2-amine;2-aMino-6-[(cyclohexylMethyl)oxy]purine;9H-Purin-2-amine, 6-(cyclohexylmethoxy)-
CBNumber: CB4498289
Molecular Formula: C12H17N5O
Formula Weight: 247.3
MOL File: 161058-83-9.mol

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NU 2058 Property

Melting point:: 199°C(lit.)
Boiling point:: 424.8±55.0 °C(Predicted)
Density: 1.52±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: DMSO: 22 mg/mL
pka: 7.36±0.20(Predicted)
form: powder to crystal
color: white
λmax: 281nm(MeOH)(lit.)
InChIKey: MWGXGTJJAOZBNW-UHFFFAOYSA-N

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37
WGK Germany: 3
HS Code: 2933.99.9000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N4286
Product name: NU 2058
Purity: >98% (HPLC)
Packaging: 5mg
Price: $84.8
Updated: 2024/03/01

TCI Chemical

Product number: N0958
Product name: NU 2058
Purity: >98.0%(HPLC)
Packaging: 20mg
Price: $141
Updated: 2024/03/01

TCI Chemical

Product number: N0958
Product name: NU 2058
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $490
Updated: 2024/03/01

Cayman Chemical

Product number: 21415
Product name: NU 2058
Purity: ≥98%
Packaging: 5mg
Price: $63
Updated: 2024/03/01

Cayman Chemical

Product number: 21415
Product name: NU 2058
Purity: ≥98%
Packaging: 10mg
Price: $106
Updated: 2024/03/01

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NU 2058 Chemical Properties,Usage,Production

Description

NU 2058 is an inhibitor of cyclin-dependent kinase 1 (Cdk1) and Cdk2 (IC₅₀s = 7.0 and 17 μM, respectively). Increased Cdk activity is often associated with human tumors, and inhibitors of Cdks, including NU 2058, can arrest cell cycling in cancer cells in vitro.

Uses

NU 2058 is an intermediate of NU 6140 (N925295), a cyclin-dependant kinase 2 inhibitor which demonstrates 10-36 fold selectivity against Cdk2-cyclin A. This selectivity induces cell-cycle arrest at the G2-M phase and potentiates the apoptotic effect of pacitaxel.

Biological Activity

Cyclin-dependent kinase (cdk) 1 and cdk2 inhibitor (K i values are 5 and 12 μ M respectively). Inhibits growth of human tumor cells in vitro (mean GI 50 = 13 μ M). Also inhibits DNA topoisomerase II ATPase activity (IC 50 = 300 μ M).

storage

Store at +4°C

NU 2058 Preparation Products And Raw materials

Raw materials

Preparation Products

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NU 2058 Suppliers

Americas 1 China 67 Europe 1 India 2 Japan 1 Switzerland 2 United Kingdom 2 United States 18 Global 94

Chengdu Kamel Pharmaceutical Co., Ltd

Tel: 028-67136579 15828051124
Email: sales@kamelpharm.com
Country: China
ProdList: 1872
Advantage: 55

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18738
Advantage: 57

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4940
Advantage: 60

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
Advantage: 80

TCI Europe

Tel: 320-37350700
Fax: +32 (0)37350701
Email: sales@tcieurope.eu
Country: Europe
ProdList: 23671
Advantage: 75

TCI AMERICA

Tel: 800-4238616
Fax: +1-888-520-1075 / +1-503-283-1987
Email: sales@tciamerica.com
Country: Americas
ProdList: 23653
Advantage: 75

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View Lastest Price from NU 2058 manufacturers

Career Henan Chemical Co

Product: NU 2058 161058-83-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000KGS
Release date: 2020-01-14

161058-83-9, NU 2058Related Search:

Roscovitine PD0332991 Isethionate Mesitylene-2-sulfonyl chloride BUTYROLACTONE I PROSTAGLANDIN A2 Flavopiridol Cdk Inhibitor, p35 Palbociclib H-ALA-ASP-ALA-GLN-HIS-ALA-THR-PRO-PRO-LYS-LYS-LYS-ARG-LYS-VAL-GLU-ASP-PRO-LYS-ASP-PHE-OH BML-259 6-Methoxyguanine 6-N-PROPOXYPURINE NU6140 6-N-BUTOXYPURINE 6-ETHOXYPURINE NU 2058 NU6102

CS-2601

NU 2058;NU-2058;NU2058

6-(Cyclohexylmethoxy)-9H-purin-2-amine

2-aMino-6-purine

2-aMino-6-[(cyclohexylMethyl)oxy]purine

2-Amino-6-(cyclohexylmethoxy)purine

NU-2058;O6-(CYCLOHEXYLMETHYL)GUANINE

NU2058&gt

9H-Purin-2-amine, 6-(cyclohexylmethoxy)-

O-Cyclohexylmethylguanine

CDK,NU 2058,guanine-based,inhibit,NU2058,Cyclin dependent kinase,anti-cancer,competitive,Inhibitor,ATP,NU-2058

161058-83-9

C12H17N5O

Protein Kinase

Cell Cycle Regulation