NU 2058
- Product Name
- NU 2058
- CAS No.
- 161058-83-9
- Chemical Name
- NU 2058
- Synonyms
- CS-2601;NU2058>2-aMino-6-purine;NU 2058;NU-2058;NU2058;O-Cyclohexylmethylguanine;2-Amino-6-(cyclohexylmethoxy)purine;NU-2058;O6-(CYCLOHEXYLMETHYL)GUANINE;6-(Cyclohexylmethoxy)-9H-purin-2-amine;2-aMino-6-[(cyclohexylMethyl)oxy]purine;9H-Purin-2-amine, 6-(cyclohexylmethoxy)-
- CBNumber
- CB4498289
- Molecular Formula
- C12H17N5O
- Formula Weight
- 247.3
- MOL File
- 161058-83-9.mol
NU 2058 Property
- Melting point:
- 199°C(lit.)
- Boiling point:
- 424.8±55.0 °C(Predicted)
- Density
- 1.52±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- DMSO: 22 mg/mL
- pka
- 7.36±0.20(Predicted)
- form
- powder to crystal
- color
- white
- λmax
- 281nm(MeOH)(lit.)
- InChIKey
- MWGXGTJJAOZBNW-UHFFFAOYSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- N4286
- Product name
- NU 2058
- Purity
- >98% (HPLC)
- Packaging
- 5mg
- Price
- $84.8
- Updated
- 2024/03/01
- Product number
- N0958
- Product name
- NU 2058
- Purity
- >98.0%(HPLC)
- Packaging
- 20mg
- Price
- $141
- Updated
- 2024/03/01
- Product number
- N0958
- Product name
- NU 2058
- Purity
- >98.0%(HPLC)
- Packaging
- 100mg
- Price
- $490
- Updated
- 2024/03/01
- Product number
- 21415
- Product name
- NU 2058
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $63
- Updated
- 2024/03/01
- Product number
- 21415
- Product name
- NU 2058
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $106
- Updated
- 2024/03/01
NU 2058 Chemical Properties,Usage,Production
Description
NU 2058 is an inhibitor of cyclin-dependent kinase 1 (Cdk1) and Cdk2 (IC50s = 7.0 and 17 μM, respectively). Increased Cdk activity is often associated with human tumors, and inhibitors of Cdks, including NU 2058, can arrest cell cycling in cancer cells in vitro.
Uses
NU 2058 is an intermediate of NU 6140 (N925295), a cyclin-dependant kinase 2 inhibitor which demonstrates 10-36 fold selectivity against Cdk2-cyclin A. This selectivity induces cell-cycle arrest at the G2-M phase and potentiates the apoptotic effect of pacitaxel.
Biological Activity
Cyclin-dependent kinase (cdk) 1 and cdk2 inhibitor (K i values are 5 and 12 μ M respectively). Inhibits growth of human tumor cells in vitro (mean GI 50 = 13 μ M). Also inhibits DNA topoisomerase II ATPase activity (IC 50 = 300 μ M).
storage
Store at +4°C
NU 2058 Preparation Products And Raw materials
Raw materials
Preparation Products
NU 2058 Suppliers
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23671
- Advantage
- 75
View Lastest Price from NU 2058 manufacturers
- Product
- NU 2058 161058-83-9
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2020-01-14