BUTYROLACTONE I

Product Name: BUTYROLACTONE I
CAS No.: 87414-49-1
Chemical Name: BUTYROLACTONE I
Synonyms: OloMoucin;BUTYROLACTONE I;Butyrolactone I - CAS 87414-49-1;Butyrolactone I, ATP-competitive cyclin-dependent kinase (CDK) inhibitor;2,5-Dihydro-4-hydroxy-2-[4-hydroxy-3-(3-methyl-2-butenyl)benzyl]-3-(4-hydroxyphenyl)-5-oxofuran-2-carboxylic acid methyl ester;2-Furancarboxylic acid, 2,5-dihydro-4-hydroxy-2-[[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]methyl]-3-(4-hydroxyphenyl)-5-oxo-, methyl ester, (2R)-
CBNumber: CB9717987
Molecular Formula: C24H24O7
Formula Weight: 424.44
MOL File: 87414-49-1.mol

More

Less

BUTYROLACTONE I Property

Melting point:: 74℃
Boiling point:: 660.1±55.0 °C(Predicted)
Density: 1.353±0.06 g/cm3(Predicted)
RTECS: LU0221600
storage temp.: Store at -20°C
solubility: Soluble in ethanol at 25mg/ml or DMSO at 10mg/ml
form: White solid.
pka: 8.59±0.40(Predicted)
color: White to off-white
Sensitive: Light Sensitive

More

Less

Safety

HS Code: 29419000

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 203988
Product name: Butyrolactone I - CAS 87414-49-1 - Calbiochem
Purity: A cell-permeable and highly selective inhibitor of cyclin-dependent protein kinases (Cdks) that inhibits cell cycle progression at the G?/S and G?/M transitions.
Packaging: 200μG
Price: $251
Updated: 2023/06/20

Alfa Aesar

Product number: J67151
Product name: Butyrolactone I, 98%
Packaging: 200microg
Price: $162
Updated: 2021/12/16

Cayman Chemical

Product number: 21765
Product name: Butyrolactone I
Purity: ≥95%
Packaging: 1mg
Price: $186
Updated: 2024/03/01

Cayman Chemical

Product number: 21765
Product name: Butyrolactone I
Purity: ≥95%
Packaging: 5mg
Price: $556
Updated: 2024/03/01

TRC

Product number: B161388
Product name: ButyrolactoneI
Packaging: 200μg
Price: $90
Updated: 2021/12/16

More

Less

BUTYROLACTONE I Chemical Properties,Usage,Production

Uses

Butyrolactone I is one of a family of three butyrolactones isolated from Aspergillus fumigatus, first reported in 1983. Butyrolactone I exhibits antitumor activity, inhibiting the cell cycle at the G1/S and G2/M transitions. Butyrolactone I is a selective inhibitor of cyclin-dependent kinases CDK1/cyclin B, CDK2 and CDK5, and is an important bioprobe for understanding the cellular roles of CDKs.

Biological Activity

Cell permeable: yes', 'Primary Target
p34cdk1/cyclinB', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 680 nM against Cdk1

Enzyme inhibitor

This natural product (FW = 424.45 g/mol), first identified in species of Aspergillus and named systematically as 2,5-dihydro-4-hydroxy 2-([4- hydroxy-3-(3-methyl-2-butenyl)phenyl]methyl)-3-(4-hydroxyphenyl)-5-oxo- 2-furancarboxylic acid methyl ester, competes with ATP in cyclindependent kinase reactions. The IC50 values for these kinases are typically 0.6-1.5 μM. Butyrolactone I also inhibits cell proliferation by the inhibiting pRb phosphorylation in IMR32 cells, causing both G1 and G2 arrest and stimulating apoptosis. Target(s): cyclin-dependent kinases 1 and 2; cdk5; protein kinase C; protein kinase A; MAP kinase; casein kinase II; [tau protein] kinase.

storage

+4°C

BUTYROLACTONE I Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

BUTYROLACTONE I Suppliers

China 24 United Kingdom 2 United States 8 Global 34

Shanghai Winherb Medical Technology Co., Ltd.

Tel: 400-186-5138 13341702378
Fax: QQ：190129269
Email: winherb@126.com
Country: China
ProdList: 1009
Advantage: 58

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9804
Advantage: 58

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57423
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Meng Cheng Technology (Shanghai) Co., LTD

Tel: 400-820-6829
Email: sales@mitachieve.com
Country: China
ProdList: 8860
Advantage: 58

Changzhou Furuisi Biotechnology Co., Ltd

Tel: 0519-85524369
Email: 3477467573@qq.com
Country: China
ProdList: 8617
Advantage: 58

Shanghai Moqi Biological Technology Co., LTD

Tel: 021-38218169 13341702378
Email: 190129269@qq.com
Country: China
ProdList: 9136
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

Guangzhou Yaoguang Technology Co., Ltd.

Tel: 13020159086
Email: yangjue@ygfuture.com
Country: China
ProdList: 422
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: 400-6206333 18021050169
Email: market@aladdin-e.com
Country: China
ProdList: 48461
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9266
Advantage: 58

Shanghai Fuorain BioTech Co., Ltd

Tel: +86-15021563149 +86-15021563149
Email: mingjin.liang@fuorain.cn
Country: China
ProdList: 1910
Advantage: 58

Chengdu Peter-like Biotechnology Co., Ltd.

Tel: 028-81700200 13308200041
Email: 2851167782@qq.com
Country: China
ProdList: 11183
Advantage: 58

Shanghai Weiyite Biotechnology Co., Ltd

Tel: 15317051735
Email: zhaojing@wytsci.com
Country: China
ProdList: 9199
Advantage: 58

Tel: 400-821-026
Email: sangon@qq.com
Country: China
ProdList: 47239
Advantage: 58

Henan Tianfu Chemical Co.,Ltd.

Tel: +86-0371-55170693 +86-19937530512
Fax: 0371-55170693
Email: info@tianfuchem.com
Country: China
ProdList: 21632
Advantage: 55

Hu Bei Jiutian Bio-medical Technology CO.,Ltd

Tel: 027-88013699 17354350817
Email: Ryan@jiutian-bio.com
Country: China
ProdList: 6001
Advantage: 58

Neobioscience Co., Ltd.

Tel: --
Fax: --
Email: info@neobioscience.com
Country: CHINA
ProdList: 6681
Advantage: 58

Proteintech China

Tel: --
Fax: --
Email: Proteintech-CN@ptglab.com
Country: CHINA
ProdList: 6290
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6705
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

87414-49-1, BUTYROLACTONE IRelated Search:

Roscovitine PD0332991 Isethionate PROSTAGLANDIN A2 Flavopiridol Cdk Inhibitor, p35 Palbociclib H-ALA-ASP-ALA-GLN-HIS-ALA-THR-PRO-PRO-LYS-LYS-LYS-ARG-LYS-VAL-GLU-ASP-PRO-LYS-ASP-PHE-OH NU 2058 BML-259 3-(4-Hydroxyphenyl)lactate Phenethyl cinnamate 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one 3-Hydroxy-4-methyl-5-ethyl-2(5H)furanone 2-ACETOXY-3-PHENYL-PROPIONIC ACID BUTYROLACTONE I 2,5-DIHYDRO-FURAN-2-CARBOXYLIC ACID 3-(4-HYDROXYPHENYL)-2-METHOXYPROPANOIC ACID

BUTYROLACTONE I

2,5-Dihydro-4-hydroxy-2-[4-hydroxy-3-(3-methyl-2-butenyl)benzyl]-3-(4-hydroxyphenyl)-5-oxofuran-2-carboxylic acid methyl ester

OloMoucin

2-Furancarboxylic acid, 2,5-dihydro-4-hydroxy-2-[[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]methyl]-3-(4-hydroxyphenyl)-5-oxo-, methyl ester, (2R)-

Butyrolactone I - CAS 87414-49-1

Butyrolactone I, ATP-competitive cyclin-dependent kinase (CDK) inhibitor

87414-49-1

Antibiotic