4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one

Product Name: 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one
CAS No.: 28664-35-9
Chemical Name: 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one
Synonyms: SOTOLON;3-hydroxy-4,5-dimethylfuran-2(5H)-one;3-HYDROXY-4,5-DIMETHYL-2(5H)-FURANONE;SOTOLONE;SUGAR LACTONE;CARAMEL FURANONE;FENUGREEK LACTONE;3-hydroxy-4,5-dimethyl-2(5H)-furanone (sotolon);FEMA 3634;3-hydroxy-4,5-dimethyl-2(5h)-furanon
CBNumber: CB6466523
Molecular Formula: C6H8O3
Formula Weight: 128.13
MOL File: 28664-35-9.mol

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4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one Property

Melting point:: 26-29 °C(lit.)
Boiling point:: 184 °C(lit.)
Density: 1.049 g/mL at 25 °C
refractive index: n20/D 1.491(lit.)
FEMA: 3634 | 4,5-DIMETHYL-3-HYDROXY-2,5-DIHYDROFURAN-2-ONE
Flash point:: >230 °F
storage temp.: Sealed in dry,2-8°C
pka: 9.28±0.40(Predicted)
Odor: at 0.01 % in propylene glycol. extremely sweet strong caramel maple burnt sugar coffee
Odor Type: caramellic
JECFA Number: 243
InChIKey: UNYNVICDCJHOPO-UHFFFAOYSA-N
LogP: -0.44
CAS DataBase Reference: 28664-35-9(CAS DataBase Reference)
NIST Chemistry Reference: 2(5H)-furanone, 3-hydroxy-4,5-dimethyl-(28664-35-9)
EPA Substance Registry System: 2(5H)-Furanone, 3-hydroxy-4,5-dimethyl- (28664-35-9)

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Safety

Hazard Codes: Xn
Risk Statements: 20/22
Safety Statements: 36
WGK Germany: 3
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: W363499
Product name: 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one
Purity: natural, ≥97%, FG
Packaging: SAMPLE-K
Price: $220
Updated: 2024/03/01

Sigma-Aldrich

Product number: W363499
Product name: 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one
Purity: natural, ≥97%, FG
Packaging: 25G
Price: $292
Updated: 2024/03/01

Sigma-Aldrich

Product number: W363499
Product name: 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one
Purity: natural, ≥97%, FG
Packaging: 100G
Price: $819
Updated: 2024/03/01

Sigma-Aldrich

Product number: W363421
Product name: 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one solution
Purity: 3?wt. % in propylene glycol
Packaging: 100g
Price: $106
Updated: 2024/03/01

Sigma-Aldrich

Product number: W363421
Product name: 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one solution
Purity: 3?wt. % in propylene glycol
Packaging: 1kg
Price: $513
Updated: 2024/03/01

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4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one Chemical Properties,Usage,Production

Chemical Properties

clear yellow liquid

Chemical Properties

3-Hydroxy-4,5-dimethyl-2(5H)-furanone was found in, for example, fenugreek, coffee, sake, and florsherry. Its aroma characteristic changes from caramel-like at low concentrations to curry-like at high concentrations. A method described for its preparation comprises condensation of ethyl propionate with diethyl oxalate and reaction of the intermediately formed diethyl oxalylpropionate with acetaldehyde. Acidic decarboxylation of the ethyl 4,5-dimethyl-2,3-dioxodihydrofuran-4-carboxylate gives the title compound.

Occurrence

Reported found in roasted Virginia tobacco, beef broth, beer, sherry, botryized wine, coffee, tea, fenugreek, sake and rice wine.

Uses

4,5-Dimethyl-3-hydroxy-2(5H)-furanone-13C3 is a labelled analogue of 4,5-Dimethyl-3-hydroxy-2(5H)-furanone (D473600). 4,5-Dimethyl-3-hydroxy-2(5H)-furanone is a fragrant compound that is a key indicator of maple syrup urine disease, a disorder affecting newborn children that is the result of its inability to properly metabolize Valine (V094205), Leucine (L330110) and Isoleucine (I820175). 4,5-Dimethyl-3-hydroxy-2(5H)-furanone is naturally found in fenugreek seeds, and is an odourant present in sherry wines.

Definition

ChEBI: Sotolone is a butenolide. It has a role as a metabolite.

Aroma threshold values

Aroma characteristics at 1.0%; sweet, strong brown, cyclotene and maple like, caramel, toffee, maltol-like and burnt, brown sugar fenugreek-like, cooked and syrupy.

Taste threshold values

Taste characteristics at 5–25 ppm; sweet, caramel, maple, walnut, brown sugar, nutty, cotton candy, fenugreek and celery-like, rum, roasted meaty with a honey nuance

4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one Suppliers

Americas 1 Belgium 1 China 186 Europe 1 Germany 4 India 7 Japan 3 South Korea 1 Switzerland 1 United Kingdom 6 United States 31 Global 242

Wuhan Haishan Technology Co. Ltd.

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View Lastest Price from 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one 28664-35-9
Price: US $75.00-25.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-27

Hebei Weibang Biotechnology Co., Ltd

Product: 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one 28664-35-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-04

JINING XINHE CHEMICAL CO., LTD

Product: 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one 28664-35-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10ton
Release date: 2024-07-18

28664-35-9, 4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-oneRelated Search:

CHLOROPHOSPHONAZO III Acetone oxime Dimethyl phthalate ETHANE Dimethyl sulfide Furazolidone Spironolactone Common Fenugreek Seed P.E. 2-Methylfuran Dimethyl sulfoxide Dimethyl fumarate Dimethyl ether N,N-Dimethylformamide DIMETHYLGLYOXIME DISODIUM SALT (-)-Corey lactone diol TRIOXSALEN 4'-Hydroxyacetophenone D-(+)-Glucono-1,5-lactone

4,5-dimethyl-3-hydroxy-2,5-dihydrofuran-2-one AKA sugar lactone

CARAMEL FURANONE (3% IN TRIACETIN)

3-HYDROXY-4,5-DIMETHYL-2(5H)-FURANONE

4,5-DIMETHYL-3-HYDROXY-2,5-DIHYDROFURAN-2-ONE

4,5-DIMETHYL-3-HYDROXY-2(5H)-FURANONE

FEMA 3634

Fenugreck Lactone

FENUGREEK LACTONE

CARAMEL FURANONE

4,5-Dimethyl-3-hydroxy-2(5H)-furanone (ca. 14% in propylene glycol)

3-hydroxy-4,5-dimethylfuran-2(5H)-one

SUGAR LACTONE PURE

4 5-DIMETHYL-3-HYDROXY-2 5-DIHYDROFURAN&

3-Hydroxy-4,5-Dimethyl-2(5H)-Furanone 28664-35-9

sotolon,3-hydroxy-4,5-dimethyl-2(5H)-furanone

4,5-dimethyl-3-hydroxy-2,5-dihydrofuran-2-one solution

caramel furanone solution

4,5-DIMETHYL-3-HYDROXY-2(5H)-FURANONE (CA. 10% IN PROPYLENE GLYCOL)

4,5-DIMETHYL-3-HYDROXY-2(5H)-FURANONE, CA. 3% IN PROPYLENE GLYCOL

4,5-DIMETHYL-3-HYDROXY-2(5H)-FURANONE 97%

4,5-Dimethyl-3-hydroxy-2(5H)-furanone (ca. 14% in Propylene Glycol, ca. 1.2mol/L)

CARAMEL FURANONE 0.1% IN P.G., NATURAL

CARAMEL FURANONE IN 3% P.G.

CARAMEL FURANONE, PURE

4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one, Caramel furanone, Sotolon, Sugar lactone

Caramel furanone, Sotolon, Sugar lactone

2,4-Dihydroxy-3,4-dimethyl-2-butenoic acid 1,4-lactone

4,5-Dimethyl-3-hydroxyfuran-2(5H)-one

RI-2177

4,5-Dimethyl-3-hydroxy-2(5H)-furanone,98%

5-dihydrofuran-2-one

5-Dimethyl-3-hydroxy-2

4-hydroxy-2,3-dimethyl-2H-furan-5-one

4,5-Dimethyl-3-hydroxy-2(5H)-furanone, 97.5%

2(5H)-Furanone, 3-hydroxy-4,5-dimethyl-

3-Hydoxy-4,5-dimethyl-2(5H)-furanone

,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one

2,3-DIMETHYL-4-HYDROXY-2,5-DIHYDROFURAN-5-ONE

4,5-dimethyl-3-hydroxy-2(5H)- furanone (sotolon)

dimethylhydroxyfuranone

Furan-2(5H)-one, 3-hydroxy-4,5-dimethyl-

3-hydroxy-4,5-dimethyl-2(5h)-furanon

3-hydroxy-4,5-dimethyl-2(5H)-furanone (sotolon)

3-hydroxy-4,5-dimethyl-5H-furan-2-one

SOTOLON

SOTOLONE

SUGAR LACTONE

Fenugreeklactone 3%

4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one/Sotolon

4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one USP/EP/BP

4,5-Dimethyl-3-hydroxy-2,5-dihydrofuran-2-one（Sugar lactone）

28664-35-9

food additives

food additive