JX401

Product Name: JX401
CAS No.: 349087-34-9
Chemical Name: JX401
Synonyms: JX401;p38 MAP Kinase Inhibitor VI, JX401;1-[2-Methoxy-4-(methylthio)benzoyl]-4-benzylpiperidine;1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine;p38 MAP Kinase Inhibitor VI, JX401 - CAS 349087-34-9 - Calbiochem;Methanone, [2-methoxy-4-(methylthio)phenyl][4-(phenylmethyl)-1-piperidinyl]-
CBNumber: CB01074327
Molecular Formula: C21H25NO2S
Formula Weight: 355.49
MOL File: 349087-34-9.mol

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JX401 Property

storage temp.: Store at RT
solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
form: Off-white solid
color: White
Stability:: Stable for 2 years from date of purchase as supplied. PROTECT FROM MOISTURE. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

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Safety

Hazard Codes: N
Risk Statements: 50/53
Safety Statements: 60-61
RIDADR: UN 3077 9/PG 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 506157
Product name: p38 MAP Kinase Inhibitor VI, JX401
Packaging: 5mg
Price: $251
Updated: 2023/06/20

Cayman Chemical

Product number: 16898
Product name: JX-401
Purity: ≥95%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 16898
Product name: JX-401
Purity: ≥95%
Packaging: 5mg
Price: $111
Updated: 2024/03/01

Cayman Chemical

Product number: 16898
Product name: JX-401
Purity: ≥95%
Packaging: 10mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 16898
Product name: JX-401
Purity: ≥95%
Packaging: 50mg
Price: $820
Updated: 2024/03/01

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JX401 Chemical Properties,Usage,Production

Description

JX401 (349087-34-9) is a potent, cell-permeable inhibitor of p38α (IC50 = 32 nM). No inhibition of p38β was observed at 10 μM.

Uses

JX-401 is a potent, reversible inhibitor of the p38α isoform of MAP kinase (IC50 = 32 nM). It does not inhibit the p38γ isoform. JX-401 is effective in mammalian cells, as it blocks the differentiation of myoblasts into myotubes.[Cayman Chemical]

Uses

JX-401 is an inhibitor of p38α isoform MAP kinase, blocks the differentiation of myoblasts and myotubes.

Definition

ChEBI: [2-methoxy-4-(methylthio)phenyl]-[4-(phenylmethyl)-1-piperidinyl]methanone is a N-acylpiperidine and a member of benzamides.

Biological Activity

Potent, reversible inhibitor of p38 α that displays no activity on the p38 γ isoform (IC 50 values are 32 nM and > 10 μ M respectively). Inhibits the differentiation of myoblasts to myotubes in mammalian cells in culture.

storage

Room temperature

References

1) Friedmann et al. (2006), JX401,a p38α inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast; Mol. Pharmacol., 70 1395.

JX401 Preparation Products And Raw materials

Raw materials

Preparation Products

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JX401 Suppliers

China 46 Germany 1 Switzerland 1 United Kingdom 1 United States 10 USA 1 Global 60

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8449
Advantage: 60

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9708
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 19892
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11289
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MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8141
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Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44941
Advantage: 58

Jinan Jiuli Biotechnology Co. , Ltd.

Tel: 2717893647 14768611851
Email: 486064515@qq.com
Country: China
ProdList: 1697
Advantage: 58

349087-34-9, JX401Related Search:

CHK2 INHIBITOR II SC-514 BML-259 GW5074 Pifithrin-α (PFTα) SB 220025 PRIMA-1 PD 169316 FHPI HCL CP 31398 SB 239063 SB 202190 CYCLIC-PIFITHRIN-ALPHA 1H-INDOLE-5-CARBOXAMIDE, 97% JX401 (2-HYDROXY-PHENYL)-PIPERIDIN-1-YL-METHANONE

JX401

1-[2-Methoxy-4-(methylthio)benzoyl]-4-benzylpiperidine

1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine

p38 MAP Kinase Inhibitor VI, JX401

p38 MAP Kinase Inhibitor VI, JX401 - CAS 349087-34-9 - Calbiochem

Methanone, [2-methoxy-4-(methylthio)phenyl][4-(phenylmethyl)-1-piperidinyl]-

349087-34-9

Intracellular Signaling