ChemicalBook > CAS DataBase List > SB 220025

SB 220025

Product Name
SB 220025
CAS No.
165806-53-1
Chemical Name
SB 220025
Synonyms
SB 220025;5-(2-AMINO-4-PYRIMIDINYL)-4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)IMIDAZOLE;5-(2-AMINO-4-PYRIMIDINYL)-4-(4-FLUOROPHENYL)-1-(4-PIPERIDINLYL)IMIDAZOLE;4-[4-(4-Fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-pyrimidinamine;4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl]pyrimidin-2-amine;2-Pyrimidinamine, 4-[4-(4-fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-
CBNumber
CB9131134
Molecular Formula
C18H19FN6
Formula Weight
338.38
MOL File
165806-53-1.mol
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SB 220025 Property

Boiling point:
611.9±65.0 °C(Predicted)
Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: 22mg/mL
pka
9.92±0.10(Predicted)
form 
White to pale amber solid.
color 
white to pale yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
559396
Product name
SB 220025
Purity
A cell-permeable, potent, reversible, ATP-competitive, and specific inhibitor of human p38 MAP Kinase (IC?? = 60 nM).
Packaging
500μG
Price
$259
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
KIN0000993
Product name
SB 220025
Purity
95.00%
Packaging
5MG
Price
$505.57
Updated
2021/12/16
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SB 220025 Chemical Properties,Usage,Production

Uses

SB 220025 is a reversible, orally active, cell-permeable, ATP-competitive and selective human p38 MAPK inhibitor (IC50 = 60 nM). SB 220025 also inhibits p56Lck and PKC with IC50 values of 3.5 and 2.89 μM, respectively. SB 220025 inhibits the expression of IL-8 gene in response to globular adiponectin (gAd), reduces inflammatory cytokine production and inhibits angiogenesis. SB 220025 effectively prevents the progression of arthritis in a chronic inflammatory disease model and can be used in the study of inflammation[1][2].

Definition

ChEBI: SB220025 is am member of the class of imidazoles carrying piperidin-4-yl, 4-fluophenyl and 2-aminopyrimidin-4-yl substituents at posiitons 1, 4 and 5 respectively. It has a role as an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor, an angiogenesis inhibitor and an anti-inflammatory agent. It is a member of piperidines, an organofluorine compound, an aminopyrimidine and a member of imidazoles.

Biological Activity

Primary Target
P38MAPK

in vivo

SB 220025 (3-50 mg/kg; p.o.; single) inhibits inflammatory cytokine production in vivo[2].
SB 220025 (5, 30, 50 mg/kg; i.p.; b.i.d.) inhibits angiogenesis in the murine air pouch granuloma model[2].
SB 220025 (30 mg/kg; p.o.; twice a day for 3, 5, 7 or 14 days) prevents the increase in angiogenesis that occurs after day 3 in murine air pouch angiogenesis model[2].
SB 220025 (50 mg/kg; p.o.; b.i.d.; 10 days) effectively blocks the progression of arthritis in a chronic inflammatory disease model[2].

Animal Model:Acute model of LPS-induced TNF-a expression[2].
Dosage:3-50 mg/kg
Administration:Oral administration; single; 30 min before challenge with LPS.
Result:Dosedependently inhibited TNF-a production with an ED50 value of 7.5 mg/kg, and showed more than 80% inhibition when at 50 mg/kg.
Animal Model:Murine air pouch granuloma model[2].
Dosage:5, 30, 50 mg/kg
Administration:Intraperitoneal injection; bisindie (bid, twice a day).
Result:Caused a dose-dependent reduction in angiogenesis.
Animal Model:Murine air pouch granuloma model[2].
Dosage:30 mg/kg
Administration:Oral administration; twice a day from day 0 until removal of granuloma tissue at days 3, 5, 7 or 14.
Result:Did not affect the initial burst of angiogenesis but did prevent the increase in angiogenesis that occurs after day 3.

IC 50

p38: 60 nM (IC50); p56-Lck: 3.5 μM (IC50); PKC: 2.89 μM (IC50)

References

[1] Tomizawa A, et al. Induction of gene expression in response to globular adiponectin in vascular endothelial cells. Life Sci. 2009 Sep 9;85(11-12):457-61. DOI:10.1016/j.lfs.2009.07.012
[2] Jackson JR, et al. Pharmacological effects of SB 220025, a selective inhibitor of P38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models. J Pharmacol Exp Ther. 1998 Feb;284(2):687-92. PMID:9454815

SB 220025 Preparation Products And Raw materials

Raw materials

Preparation Products

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SB 220025 Suppliers

China 28 Japan 1 Switzerland 1 United Kingdom 1 United States 3 Global 34
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2986
Advantage
58
Chuzhou KeMail Chemical Technology Co., Ltd
Tel
0550-5196001 15000891977
Fax
0550-5196001
Email
wj520wjxby@126.com
Country
China
ProdList
1944
Advantage
55
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Shanghai Tachizaki Biomedical Research Center
Tel
18014399201
Email
sales@chemlab-tachizaki.com
Country
China
ProdList
2742
Advantage
58
Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
5929
Advantage
58
Foshan Heshuo Pharm technology Co., ltd
Tel
15363639686
Email
heshuoyiyao@hotmail.com
Country
China
ProdList
2374
Advantage
58
Anqing YanZhi Pharma Discovery Co.,Ltd.
Tel
18055651951
Email
2272561977@qq.com
Country
China
ProdList
435
Advantage
58
Merck Millipore
Tel
1-400-889-1988 400-889-1988
Email
bioscience@merckgroup.com
Country
China
ProdList
6839
Advantage
58

165806-53-1, SB 220025Related Search:

Pifithrin-α (PFTα) PRIMA-1 PD 169316 FHPI HCL CP 31398 SB 239063 SB 202190 CYCLIC-PIFITHRIN-ALPHA 1H-INDOLE-5-CARBOXAMIDE, 97% JX401 5-(2-AMINOPYRIMIDIN-4-YL)-4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)IMIDAZOLE TRIHYDROCHLORIDE 4-(1H-Imidazol-1-yl)piperidine SB 220025

  • 5-(2-AMINO-4-PYRIMIDINYL)-4-(4-FLUOROPHENYL)-1-(4-PIPERIDINLYL)IMIDAZOLE
  • 5-(2-AMINO-4-PYRIMIDINYL)-4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)IMIDAZOLE
  • SB 220025
  • 4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl]pyrimidin-2-amine
  • 2-Pyrimidinamine, 4-[4-(4-fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-
  • 4-[4-(4-Fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-pyrimidinamine
  • 165806-53-1
  • C18H19FN6