ChemicalBook > CAS DataBase List > CYCLIC-PIFITHRIN-ALPHA
CYCLIC-PIFITHRIN-ALPHA
- Product Name
- CYCLIC-PIFITHRIN-ALPHA
- CAS No.
- 60477-34-1
- Chemical Name
- CYCLIC-PIFITHRIN-ALPHA
- Synonyms
- Pifithrin-2;Pifithrin-alpha (cyclic) . HBr;Pifithrin-β (QB-102 and Cyclic-Pifithrin-α);Pifithrin-α, Cyclic- - CAS 60477-34-1 - Calbiochem;2-(p-Tolyl)-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]thiazole;5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazole;Imidazo[2,1-b]benzothiazole, 5,6,7,8-tetrahydro-2-(4-methylphenyl)-
- CBNumber
- CB2504209
- Molecular Formula
- C16H16N2S
- Formula Weight
- 268.38
- MOL File
- 60477-34-1.mol
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CYCLIC-PIFITHRIN-ALPHA Property
- Melting point:
- 266.4-267.3 °C(lit.)
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- DMSO: 20 mg/mL
- form
- White solid
- pka
- 6.75±0.20(Predicted)
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
ApexBio Technology
- Product number
- B4813
- Product name
- Pifithrin-β
- Packaging
- 5mg
- Price
- $87
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B4813
- Product name
- Pifithrin-β
- Packaging
- 10mg
- Price
- $148
- Updated
- 2021/12/16
Axon Medchem
- Product number
- Axon3051
- Product name
- Pifithrin-β-PFT-β|Z-2-035II
- Purity
- 99%
- Packaging
- 2x10mg
- Price
- $165
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- API0017104
- Product name
- PIFITHRIN-B
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.16
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B4813
- Product name
- Pifithrin-β
- Packaging
- 50mg
- Price
- $607
- Updated
- 2021/12/16
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CYCLIC-PIFITHRIN-ALPHA Chemical Properties,Usage,Production
Definition
ChEBI: 2-(4-methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole is a member of imidazoles.
General Description
A cell-permeable and very stable analog of Pifithrin-α (Cat. No. 506132), with similar biological function, but with reduced cytotoxicity. A chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes; also reversibly blocks p53-mediated apoptosis. Acts as a P-gp modulator by changing relative substrate specificity of the transporter. This compound has been reported to be a potent STAT6 transcriptional inhibitor.
Biochem/physiol Actions
Cell permeable: yes
CYCLIC-PIFITHRIN-ALPHA Preparation Products And Raw materials
Raw materials
Preparation Products
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CYCLIC-PIFITHRIN-ALPHA Suppliers
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60477-34-1, CYCLIC-PIFITHRIN-ALPHARelated Search:
Pifithrin-α (PFTα)
SB 220025
PRIMA-1
PD 169316
FHPI HCL
CP 31398
SB 239063
SB 202190
1H-INDOLE-5-CARBOXAMIDE, 97%
JX401