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CYCLIC-PIFITHRIN-ALPHA

Product Name
CYCLIC-PIFITHRIN-ALPHA
CAS No.
60477-34-1
Chemical Name
CYCLIC-PIFITHRIN-ALPHA
Synonyms
Pifithrin-2;Pifithrin-alpha (cyclic) . HBr;Pifithrin-β (QB-102 and Cyclic-Pifithrin-α);Pifithrin-α, Cyclic- - CAS 60477-34-1 - Calbiochem;2-(p-Tolyl)-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]thiazole;5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazole;Imidazo[2,1-b]benzothiazole, 5,6,7,8-tetrahydro-2-(4-methylphenyl)-
CBNumber
CB2504209
Molecular Formula
C16H16N2S
Formula Weight
268.38
MOL File
60477-34-1.mol
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CYCLIC-PIFITHRIN-ALPHA Property

Melting point:
266.4-267.3 °C(lit.)
Density 
1.30±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
DMSO: 20 mg/mL
form 
White solid
pka
6.75±0.20(Predicted)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology
Product number
B4813
Product name
Pifithrin-β
Packaging
5mg
Price
$87
Updated
2021/12/16
ApexBio Technology
Product number
B4813
Product name
Pifithrin-β
Packaging
10mg
Price
$148
Updated
2021/12/16
Axon Medchem
Product number
Axon3051
Product name
Pifithrin-β-PFT-β|Z-2-035II
Purity
99%
Packaging
2x10mg
Price
$165
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0017104
Product name
PIFITHRIN-B
Purity
95.00%
Packaging
5MG
Price
$497.16
Updated
2021/12/16
ApexBio Technology
Product number
B4813
Product name
Pifithrin-β
Packaging
50mg
Price
$607
Updated
2021/12/16
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CYCLIC-PIFITHRIN-ALPHA Chemical Properties,Usage,Production

Definition

ChEBI: 2-(4-methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole is a member of imidazoles.

General Description

A cell-permeable and very stable analog of Pifithrin-α (Cat. No. 506132), with similar biological function, but with reduced cytotoxicity. A chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes; also reversibly blocks p53-mediated apoptosis. Acts as a P-gp modulator by changing relative substrate specificity of the transporter. This compound has been reported to be a potent STAT6 transcriptional inhibitor.

Biochem/physiol Actions

Cell permeable: yes

CYCLIC-PIFITHRIN-ALPHA Preparation Products And Raw materials

Raw materials

Preparation Products

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CYCLIC-PIFITHRIN-ALPHA Suppliers

SIGMA-RBI
Tel
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Fax
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Country
Switzerland
ProdList
6896
Advantage
91

60477-34-1, CYCLIC-PIFITHRIN-ALPHARelated Search:


  • Pifithrin-α, Cyclic- - CAS 60477-34-1 - Calbiochem
  • Pifithrin-alpha (cyclic) . HBr
  • 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazole
  • Pifithrin-2
  • Imidazo[2,1-b]benzothiazole, 5,6,7,8-tetrahydro-2-(4-methylphenyl)-
  • Pifithrin-β (QB-102 and Cyclic-Pifithrin-α)
  • 2-(p-Tolyl)-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]thiazole
  • 60477-34-1