ChemicalBook > CAS DataBase List > Roxatidine

Roxatidine

Product Name
Roxatidine
CAS No.
78273-80-0
Chemical Name
Roxatidine
Synonyms
ROXATIDINE;desacetyl-TZU-0460;Roxatidine USP/EP/BP;RoxatidineAcetateHclBase;Roxatidine in acetonitrile;ROXATIDINE ENTERPRISE STANDARD;ROXATIDINE(SUBJECTTOPATENTFREE);Benzaldehyde,5-methoxy-7-nitro-;n-{3-[3-(1-piperidinylmethyl)phenoxy]propyl}hydroxyacetamide;2-Hydroxy-N-[3-[m-(piperidinomethyl)phenoxy]propyl]acetamide
CBNumber
CB1472068
Molecular Formula
C17H26N2O3
Formula Weight
306.4
MOL File
78273-80-0.mol
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Roxatidine Property

Melting point:
59-60 °C
Boiling point:
524.3±45.0 °C(Predicted)
Density 
1.137±0.06 g/cm3(Predicted)
storage temp. 
-20°
solubility 
Soluble in DMSO (up to 25 mg/ml).
pka
13.34±0.10(Predicted)
form 
oil
color 
Colorless to pale yellow
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
CAS DataBase Reference
78273-80-0(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0005304
Product name
ROXATIDINE
Purity
95.00%
Packaging
5MG
Price
$504.65
Updated
2021/12/16
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Roxatidine Chemical Properties,Usage,Production

Description

Roxatidine (78273-80-0) is a novel histamine H2 receptor antagonist.1?Suppresses inflammatory responses via inhibition of NFκB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages.2?Clinically useful agent for prevention and healing of gastric and duodenal ulcers and bleeding.3?Attenuates degradation of extracellular matrix in osteoarthritis models by inactivating the NFkB pathway.4

Uses

Anti-ulcerative.

in vivo

Roxatidine (20 mg/kg, p.o., a single dose for 1h before Compound 48/80 injection) ameliorates Compound 48/80 (HY-115768) (8mg/kg, i.p., a single dose for 1h)-induced allergic hypersensitivity and suppresses Compound 48/80-induced allergic inflammation in anaphylactic animal model[1].

Animal Model:Compound 48/80-induced anaphylactic shock mouse model[1]
Dosage:20 mg/kg
Administration:p.o., a single dose for 1h before Compound 48/80 injection
Result:Increased the survival rate to 20% at 60 min after compound 48/80 injection.

IC 50

H2 Receptor

References

[1] J G MILLS  J R W. The pharmacology of histamine H2-receptor antagonists.[J]. Methods and findings in experimental and clinical pharmacology, 1989, 11 Suppl 1: 87-95.
[2] EU-JIN CHO. Roxatidine suppresses inflammatory responses via inhibition of NF-κB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages†[J]. Journal of cellular biochemistry, 2011, 112 12: 3648-3659. DOI:10.1002/jcb.23294
[3] HIROYUKI IMAEDA. Effect of lansoprazole versus roxatidine on prevention of bleeding and promotion of ulcer healing after endoscopic submucosal dissection for superficial gastric neoplasia.[J]. Journal of Gastroenterology, 2011, 46 11: 1267-1272. DOI:10.1007/s00535-011-0447-1
[4] RENHAO ZE. Roxatidine Attenuates Degradation of Extracellular Matrix.[J]. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017: 1156-1160. DOI:10.1016/j.biopha.2017.08.130

Roxatidine Preparation Products And Raw materials

Raw materials

Preparation Products

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Roxatidine Suppliers

China 86 Europe 2 Germany 1 India 2 United Kingdom 3 United States 13 Global 107
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768836
Email
1791901229@qq.com
Country
China
ProdList
6950
Advantage
52
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18333
Advantage
56
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
Advantage
50
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Wuhan FengyaoTonghui Chemical Products Co., Ltd.
Tel
027-87466105 15377573527
Email
2678564200@qq.com
Country
China
ProdList
17987
Advantage
58
Nanjing Daqin Pharmaceutical Technology Co., Ltd.
Tel
025-025-58470199 18351831988
Fax
025-58470199
Email
sales@daqinpharma.cn
Country
China
ProdList
312
Advantage
58
Chengdu Saint - Kay Biotechnology Co., Ltd.
Tel
028-85157043 15882256948
Email
676046971@qq.com
Country
China
ProdList
4181
Advantage
58
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View Lastest Price from Roxatidine manufacturers

Sinoway Industrial co., ltd.
Product
Roxatidine 78273-80-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2024-11-29
Hebei Chuanghai Biotechnology Co., Ltd
Product
Roxatidine 78273-80-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-29
Shaanxi Dideu Medichem Co. Ltd
Product
Roxatidine 78273-80-0
Price
US $1.00-1.00/Kg/Bag
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-04-30

78273-80-0, RoxatidineRelated Search:

Acetamide Famotidine Propyl butyrate Thioacetamide 3-Mercaptopropyltriethoxysilane Cimetidine DIACETAMIDE Propyl gallate Acetaminophen 3-Chloropropyltriethoxysilane 3-Aminopropyltriethoxysilane N,N-Dimethylacetamide 3-(1-Piperidinylmethyl)phenol ROXATIDINE OXALATE ROXATIDINE ACETATE ROXATIDINE ACETATE HYDROCHLORIDE,ROXATIDINE ACETATE HCL,ROXATIDINE HCL ACETATE N-[3-[3-(1-Piperidinylmethyl)phenoxy]propyl]amine 2-HYDROXYACETAMIDE

  • ROXATIDINE
  • n-{3-[3-(1-piperidinylmethyl)phenoxy]propyl}hydroxyacetamide
  • 2-Hydroxy-N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]acetamide
  • 2-Hydroxy-N-[3-[m-(piperidinomethyl)phenoxy]propyl]acetamide
  • ROXATIDINE ENTERPRISE STANDARD
  • RoxatidineAcetateHclBase
  • ROXATIDINE(SUBJECTTOPATENTFREE)
  • desacetyl-TZU-0460
  • 2-hydroxy-N-[3-[3-(piperidinomethyl)phenoxy]propyl] acetamide
  • 2-hydroxy-N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]acetamide hydrochloride
  • Acetamide, 2-hydroxy-N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-
  • Roxatidine USP/EP/BP
  • Benzaldehyde,5-methoxy-7-nitro-
  • Roxatidine in acetonitrile
  • 78273-80-0
  • 8273-80-0
  • C17H26N2O3
  • APIs