3-(1-Piperidinylmethyl)phenol
- Product Name
- 3-(1-Piperidinylmethyl)phenol
- CAS No.
- 73279-04-6
- Chemical Name
- 3-(1-Piperidinylmethyl)phenol
- Synonyms
- Piperidinol;3-(1-Piperidinyl;BUTTPARK 99\50-17;Roxatidine Impurity 4;3-(1-Piperidinyl)Phenol;3-(Piperidinomethyl)phenol;m-(Piperidinomethyl)phenol;3-(1-Piperidylmethyl)phenol;3-(1-PIPERIDINOMETHYL)PHENOL;3-(1-PIPERIDINYLMETHYL)PHENOL
- CBNumber
- CB6328672
- Molecular Formula
- C12H17NO
- Formula Weight
- 191.27
- MOL File
- 73279-04-6.mol
3-(1-Piperidinylmethyl)phenol Property
- Melting point:
- 137-138°C
- Boiling point:
- 308.1±17.0 °C(Predicted)
- Density
- 1.097±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 9.97±0.10(Predicted)
- color
- White to Almost white
- InChI
- InChI=1S/C12H17NO/c14-12-6-4-5-11(9-12)10-13-7-2-1-3-8-13/h4-6,9,14H,1-3,7-8,10H2
- InChIKey
- ORGBERFQYFWYGX-UHFFFAOYSA-N
- SMILES
- C1(O)=CC=CC(CN2CCCCC2)=C1
- CAS DataBase Reference
- 73279-04-6(CAS DataBase Reference)
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- T311855
- Product name
- 3-(1-PIPERIDINYLMETHYL)PHENOL
- Purity
- AldrichCPR
- Packaging
- 5MG
- Price
- $138
- Updated
- 2023/06/20
- Product number
- H1183
- Product name
- 1-(3-Hydroxybenzyl)piperidine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $105
- Updated
- 2025/07/31
- Product number
- H1183
- Product name
- 1-(3-Hydroxybenzyl)piperidine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $417
- Updated
- 2025/07/31
- Product number
- B448963
- Product name
- 3-(Piperidin-1-ylmethyl)phenol
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B448963
- Product name
- 3-(Piperidin-1-ylmethyl)phenol
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
3-(1-Piperidinylmethyl)phenol Chemical Properties,Usage,Production
Synthesis
110-89-4
100-83-4
73279-04-6
In a three-necked flask equipped with a stirrer, condenser tube and thermometer, add 2.4 g of m-hydroxybenzaldehyde dissolved in 40 mL of formic acid with stirring. The temperature was controlled to be below 60 °C and 4.2 g of hexahydropyridine was slowly added dropwise. After the dropwise addition was completed, the temperature was raised to 110 °C and the reaction was refluxed for 2 h (the progress of the reaction was monitored by thin layer chromatography). Upon completion of the reaction, the reaction solution was diluted with 150 mL of water and cooled to 15 °C. Decolorization was carried out by adding 0.1 g of activated carbon and filtered. The pH of the filtrate was adjusted with 12% ammonia to 8.5. allowed to stand and crystallized at 10 °C. The crystals were collected by filtration, washed with cold water and dried to give Intermediate III-1 (3-(1-piperidinylmethyl)phenol) 3.0 g as yellow crystals in 78% yield.
References
[1] Arzneimittel-Forschung/Drug Research, 1985, vol. 35, # 7, p. 1025 - 1029
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 4, p. 989 - 994
[3] ChemMedChem, 2015, vol. 10, # 1, p. 83 - 93
[4] Patent: CN103626722, 2016, B. Location in patent: Paragraph 0049-0052
[5] Synthetic Communications, 1999, vol. 29, # 1, p. 15 - 20
3-(1-Piperidinylmethyl)phenol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-(1-Piperidinylmethyl)phenol manufacturers
- Product
- 3-(1-Piperidinylmethyl)phenol 73279-04-6
- Price
- US $0.00-0.00/g
- Min. Order
- 5g
- Purity
- 99%+
- Supply Ability
- 100 tons
- Release date
- 2019-12-25
- Product
- 3-(1-Piperidinylmethyl)phenol 73279-04-6
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 96%-99%
- Supply Ability
- as request
- Release date
- 2018-12-23