3-(1-Piperidinylmethyl)phenol

Product Name: 3-(1-Piperidinylmethyl)phenol
CAS No.: 73279-04-6
Chemical Name: 3-(1-Piperidinylmethyl)phenol
Synonyms: Piperidinol;3-(1-Piperidinyl;BUTTPARK 99\50-17;Roxatidine Impurity 4;3-(1-Piperidinyl)Phenol;3-(Piperidinomethyl)phenol;m-(Piperidinomethyl)phenol;3-(1-Piperidylmethyl)phenol;3-(1-PIPERIDINOMETHYL)PHENOL;3-(1-PIPERIDINYLMETHYL)PHENOL
CBNumber: CB6328672
Molecular Formula: C12H17NO
Formula Weight: 191.27
MOL File: 73279-04-6.mol

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3-(1-Piperidinylmethyl)phenol Property

Melting point:: 137-138°C
Boiling point:: 308.1±17.0 °C(Predicted)
Density: 1.097±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 9.97±0.10(Predicted)
color: White to Almost white
InChI: InChI=1S/C12H17NO/c14-12-6-4-5-11(9-12)10-13-7-2-1-3-8-13/h4-6,9,14H,1-3,7-8,10H2
InChIKey: ORGBERFQYFWYGX-UHFFFAOYSA-N
SMILES: C1(O)=CC=CC(CN2CCCCC2)=C1
CAS DataBase Reference: 73279-04-6(CAS DataBase Reference)

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T311855
Product name: 3-(1-PIPERIDINYLMETHYL)PHENOL
Purity: AldrichCPR
Packaging: 5MG
Price: $138
Updated: 2023/06/20

TCI Chemical

Product number: H1183
Product name: 1-(3-Hydroxybenzyl)piperidine
Purity: >98.0%(GC)
Packaging: 5g
Price: $105
Updated: 2025/07/31

TCI Chemical

Product number: H1183
Product name: 1-(3-Hydroxybenzyl)piperidine
Purity: >98.0%(GC)
Packaging: 25g
Price: $417
Updated: 2025/07/31

TRC

Product number: B448963
Product name: 3-(Piperidin-1-ylmethyl)phenol
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B448963
Product name: 3-(Piperidin-1-ylmethyl)phenol
Packaging: 100mg
Price: $60
Updated: 2021/12/16

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3-(1-Piperidinylmethyl)phenol Chemical Properties,Usage,Production

Synthesis

110-89-4

100-83-4

73279-04-6

In a three-necked flask equipped with a stirrer, condenser tube and thermometer, add 2.4 g of m-hydroxybenzaldehyde dissolved in 40 mL of formic acid with stirring. The temperature was controlled to be below 60 °C and 4.2 g of hexahydropyridine was slowly added dropwise. After the dropwise addition was completed, the temperature was raised to 110 °C and the reaction was refluxed for 2 h (the progress of the reaction was monitored by thin layer chromatography). Upon completion of the reaction, the reaction solution was diluted with 150 mL of water and cooled to 15 °C. Decolorization was carried out by adding 0.1 g of activated carbon and filtered. The pH of the filtrate was adjusted with 12% ammonia to 8.5. allowed to stand and crystallized at 10 °C. The crystals were collected by filtration, washed with cold water and dried to give Intermediate III-1 (3-(1-piperidinylmethyl)phenol) 3.0 g as yellow crystals in 78% yield.

References

[1] Arzneimittel-Forschung/Drug Research, 1985, vol. 35, # 7, p. 1025 - 1029
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 4, p. 989 - 994
[3] ChemMedChem, 2015, vol. 10, # 1, p. 83 - 93
[4] Patent: CN103626722, 2016, B. Location in patent: Paragraph 0049-0052
[5] Synthetic Communications, 1999, vol. 29, # 1, p. 15 - 20

3-(1-Piperidinylmethyl)phenol Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(1-Piperidinylmethyl)phenol Suppliers

Americas 1 Belgium 1 China 143 Europe 3 France 2 Germany 3 India 7 Japan 1 Switzerland 3 The Netherlands 1 United Kingdom 13 United States 28 Global 206

Matrix Fine Chemicals GmbH

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Email: nfo@matrix-fine-chemicals.com
Country: Switzerland
ProdList: 6968
Advantage: 58

Achemica

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Email: contact@achemica.com
Country: Switzerland
ProdList: 6155
Advantage: 50

Biosynth AG

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Email: welcome@biosynth.ch
Country: Switzerland
ProdList: 3324
Advantage: 72

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View Lastest Price from 3-(1-Piperidinylmethyl)phenol manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 3-(1-Piperidinylmethyl)phenol 73279-04-6
Price: US $0.00-0.00/g
Min. Order: 5g
Purity: 99%+
Supply Ability: 100 tons
Release date: 2019-12-25

Career Henan Chemical Co

Product: 3-(1-Piperidinylmethyl)phenol 73279-04-6
Price: US $1.00/kg
Min. Order: 1kg
Purity: 96%-99%
Supply Ability: as request
Release date: 2018-12-23

73279-04-6, 3-(1-Piperidinylmethyl)phenolRelated Search:

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3-(1-Piperidinylmethyl)phenol ISO 9001：2015 REACH

3-(1-Piperidylmethyl)phenol

(1-(3-(3-(piperidin-1-ylmethyl)phenoxy)propyl)-1,4,5,6-tetrahydropyrimidin-2-yl)methyl acetate

3-(1-Piperidinylmethyl)phenol-1-(3-Hydroxyphenylmethyl)piperidine

73279-04-6

73279-01-6

C12H17NO

(intermediate of roxatidine)