ChemicalBook > CAS DataBase List > 3-(1-Piperidinylmethyl)phenol

3-(1-Piperidinylmethyl)phenol

Product Name
3-(1-Piperidinylmethyl)phenol
CAS No.
73279-04-6
Chemical Name
3-(1-Piperidinylmethyl)phenol
Synonyms
Piperidinol;3-(1-Piperidinyl;BUTTPARK 99\50-17;Roxatidine Impurity 4;3-(1-Piperidinyl)Phenol;3-(Piperidinomethyl)phenol;m-(Piperidinomethyl)phenol;3-(1-Piperidylmethyl)phenol;3-(1-PIPERIDINOMETHYL)PHENOL;3-(1-PIPERIDINYLMETHYL)PHENOL
CBNumber
CB6328672
Molecular Formula
C12H17NO
Formula Weight
191.27
MOL File
73279-04-6.mol
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3-(1-Piperidinylmethyl)phenol Property

Melting point:
137-138°C
Boiling point:
308.1±17.0 °C(Predicted)
Density 
1.097±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
9.97±0.10(Predicted)
color 
White to Almost white
InChI
InChI=1S/C12H17NO/c14-12-6-4-5-11(9-12)10-13-7-2-1-3-8-13/h4-6,9,14H,1-3,7-8,10H2
InChIKey
ORGBERFQYFWYGX-UHFFFAOYSA-N
SMILES
C1(O)=CC=CC(CN2CCCCC2)=C1
CAS DataBase Reference
73279-04-6(CAS DataBase Reference)
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T311855
Product name
3-(1-PIPERIDINYLMETHYL)PHENOL
Purity
AldrichCPR
Packaging
5MG
Price
$138
Updated
2023/06/20
TCI Chemical
Product number
H1183
Product name
1-(3-Hydroxybenzyl)piperidine
Purity
>98.0%(GC)
Packaging
5g
Price
$105
Updated
2025/07/31
TCI Chemical
Product number
H1183
Product name
1-(3-Hydroxybenzyl)piperidine
Purity
>98.0%(GC)
Packaging
25g
Price
$417
Updated
2025/07/31
TRC
Product number
B448963
Product name
3-(Piperidin-1-ylmethyl)phenol
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
B448963
Product name
3-(Piperidin-1-ylmethyl)phenol
Packaging
100mg
Price
$60
Updated
2021/12/16
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3-(1-Piperidinylmethyl)phenol Chemical Properties,Usage,Production

Synthesis

110-89-4

100-83-4

73279-04-6

In a three-necked flask equipped with a stirrer, condenser tube and thermometer, add 2.4 g of m-hydroxybenzaldehyde dissolved in 40 mL of formic acid with stirring. The temperature was controlled to be below 60 °C and 4.2 g of hexahydropyridine was slowly added dropwise. After the dropwise addition was completed, the temperature was raised to 110 °C and the reaction was refluxed for 2 h (the progress of the reaction was monitored by thin layer chromatography). Upon completion of the reaction, the reaction solution was diluted with 150 mL of water and cooled to 15 °C. Decolorization was carried out by adding 0.1 g of activated carbon and filtered. The pH of the filtrate was adjusted with 12% ammonia to 8.5. allowed to stand and crystallized at 10 °C. The crystals were collected by filtration, washed with cold water and dried to give Intermediate III-1 (3-(1-piperidinylmethyl)phenol) 3.0 g as yellow crystals in 78% yield.

References

[1] Arzneimittel-Forschung/Drug Research, 1985, vol. 35, # 7, p. 1025 - 1029
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 4, p. 989 - 994
[3] ChemMedChem, 2015, vol. 10, # 1, p. 83 - 93
[4] Patent: CN103626722, 2016, B. Location in patent: Paragraph 0049-0052
[5] Synthetic Communications, 1999, vol. 29, # 1, p. 15 - 20

3-(1-Piperidinylmethyl)phenol Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(1-Piperidinylmethyl)phenol Suppliers

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View Lastest Price from 3-(1-Piperidinylmethyl)phenol manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
3-(1-Piperidinylmethyl)phenol 73279-04-6
Price
US $0.00-0.00/g
Min. Order
5g
Purity
99%+
Supply Ability
100 tons
Release date
2019-12-25
Career Henan Chemical Co
Product
3-(1-Piperidinylmethyl)phenol 73279-04-6
Price
US $1.00/kg
Min. Order
1kg
Purity
96%-99%
Supply Ability
as request
Release date
2018-12-23

73279-04-6, 3-(1-Piperidinylmethyl)phenolRelated Search:

Chlorodimethylphenylsilane Roxatidine acetate hydrochloride Phenol o-Cresol Xylenol 3-Trifluoromethylphenol 2,2,6,6-Tetramethylpiperidinooxy 4-Aminophenol p-Cresol Nonylphenol 2,2,6,6-Tetramethyl-4-piperidinol Cresol Roxatidine-d10 HeMioxalate N-[3-[3-(1-Piperidinylmethyl)phenoxy]propyl]amine Phenol Red Silicone oil (high temperature) Folin-Phenol Reagent Piperidine

  • (4-FLUORO-PHENYL)-PIPERIDIN-4-YL-METHANONE HYDROCHLORIDE
  • Roxatidine Impurity 4
  • 1-(3-HYDROXYPHENYLMETHYL)PIPERIDINE
  • 3-(1-PIPERIDINOMETHYL)PHENOL
  • 3-(1-PIPERIDINYLMETHYL)PHENOL
  • BUTTPARK 99\50-17
  • Piperidinol
  • 4-(4-FLUOROBENZOYL)PIPERIDINE HCL
  • 4-(P-FLUOROBENZOYL)PIPERIDINE HYDROCHLORIDE
  • 4-FLUOROPHENYL 4-PIPERIDINYL METHANONE
  • Roxatidine Acetate Impurity 4
  • 3-(1-Piperidinyl)Phenol
  • 3-(1-Piperidinyl
  • 3-(piperidin-1-ylmethyl)phenol
  • 3-(Piperidinomethyl)phenol
  • m-(Piperidinomethyl)phenol
  • 1-(3-Hydroxybenzyl)piperidine&gt
  • Phenol, 3-(1-piperidinylmethyl)-
  • 3-(1-Piperidinylmethyl)phenol ISO 9001：2015 REACH
  • 3-(1-Piperidylmethyl)phenol
  • (1-(3-(3-(piperidin-1-ylmethyl)phenoxy)propyl)-1,4,5,6-tetrahydropyrimidin-2-yl)methyl acetate
  • 3-(1-Piperidinylmethyl)phenol-1-(3-Hydroxyphenylmethyl)piperidine
  • 73279-04-6
  • 73279-01-6
  • C12H17NO
  • (intermediate of roxatidine)