ChemicalBook > CAS DataBase List > (S)-4-Hydroxy-2-pyrrolidinone

(S)-4-Hydroxy-2-pyrrolidinone

Product Name
(S)-4-Hydroxy-2-pyrrolidinone
CAS No.
68108-18-9
Chemical Name
(S)-4-Hydroxy-2-pyrrolidinone
Synonyms
SHPD;OxiracetaM iMpurity A;Oxiracetam Impurity 9;Oxiracetam impurity H;Oxiracetam Impurity N;Busulfan Impurity1706;Oxiracetam impurities1718;4-HYDROXY-PYRROLIDIN-2-ONE;(S)-4-HYDROXY-2-PYRROLIDONE;(s)-β-hydroxy-γ-butyrolactam
CBNumber
CB1474345
Molecular Formula
C4H7NO2
Formula Weight
101.1
MOL File
68108-18-9.mol
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(S)-4-Hydroxy-2-pyrrolidinone Property

Melting point:
156-159 °C (lit.)
alpha 
-41 º (c=% in ethanol)
Boiling point:
363.6±35.0 °C(Predicted)
Density 
1.292±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
Water Solubility 
Slightly soluble in water
pka
13.62±0.20(Predicted)
form 
Solid
color 
White to off-white
optical activity
[α]23/D 43°, c = 1 in ethanol
BRN 
1524192
InChIKey
IOGISYQVOGVIEU-VKHMYHEASA-N
CAS DataBase Reference
68108-18-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-41
Safety Statements 
22-24/25-36-26
WGK Germany 
3
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
479179
Product name
(S)-(?)-4-Hydroxy-2-pyrrolidinone
Purity
97%
Packaging
5g
Price
$94
Updated
2024/03/01
Sigma-Aldrich
Product number
479179
Product name
(S)-(?)-4-Hydroxy-2-pyrrolidinone
Purity
97%
Packaging
1g
Price
$52.5
Updated
2023/06/20
TCI Chemical
Product number
H1368
Product name
(S)-(-)-4-Hydroxy-2-pyrrolidone
Purity
>98.0%(GC)
Packaging
1g
Price
$205
Updated
2024/03/01
Alfa Aesar
Product number
H66455
Product name
(S)-(-)-4-Hydroxy-2-pyrrolidinone, 97+%
Packaging
250mg
Price
$36.7
Updated
2023/06/20
Alfa Aesar
Product number
H66455
Product name
(S)-(-)-4-Hydroxy-2-pyrrolidinone, 97+%
Packaging
1g
Price
$106
Updated
2023/06/20
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(S)-4-Hydroxy-2-pyrrolidinone Chemical Properties,Usage,Production

Chemical Properties

White crystal

Uses

(S)-(?)-4-Hydroxy-2-pyrrolidinone can be used as a starting material in the preparation of:

  • Biologically significant pyrrolo[1,2:1′,2′]azepino[5,6-b]indole derivatives.
  • Substituted azepanes by reacting with various aldehydes via photochemical [5+2] cycloaddition.

Uses

The (S)-enantiomer intermediate in the preparation of Oxiracetam

General Description

4-Hydroxy-2-pyrrolidinone is an important building block found in many bioactive compounds like streptopyrrolidine. It can be used as an intermediate in the synthesis of various γ-amino acids (GABA) and substituted 2-pyrrolidinones like cynometrine and cynodine.

(S)-4-Hydroxy-2-pyrrolidinone Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-4-Hydroxy-2-pyrrolidinone Suppliers

Americas 1 Canada 2 China 182 Europe 1 France 1 Germany 5 India 13 Japan 4 South Korea 3 Switzerland 2 United Kingdom 14 United States 44 Global 272
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View Lastest Price from (S)-4-Hydroxy-2-pyrrolidinone manufacturers

R&D Scientific Inc.
Product
4-Hydroxy-2-pyrrolidone 68108-18-9
Price
US $2800.00/Kg
Min. Order
1Kg
Purity
98
Supply Ability
500 Kg
Release date
2024-05-08
Zhuozhou Wenxi import and Export Co., Ltd
Product
(S)-4-Hydroxy-2-pyrrolidinone 68108-18-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
(S)-4-Hydroxy-2-pyrrolidinone 68108-18-9
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
as request
Release date
2018-12-24

68108-18-9, (S)-4-Hydroxy-2-pyrrolidinoneRelated Search:

N-Vinyl-2-pyrrolidone CHLOROPHOSPHONAZO III Polyvinylpyrrolidone 2-Pyrrolidinone N-Methyl-2-pyrrolidone Povidone iodine 4-hydroxypyrrolidin-2-one OxiracetaM Related CoMpound 2 Oxiracetam Related Compound 7 Oxiracetam 2-(2-oxo-2,5-dihydro-1H-pyrrol-1-yl)acetaMide Oxiracetam Related Compound 8 methyl 4-hydroxy-2-oxopyrrolidine-1-acetate 2-[(carbamoylmethyl)amino]acetamide Oxiracetam Related Compound 5 4-Hydroxy-2-oxo-1-pyrrolidineacetic acid (4S)-4-hydroxy-2-oxo-1-Pyrrolidineacetic acid Methyl ester ethyl 4-hydroxy-2-oxopyrrolidine-1-acetate

  • 2-PYRROLIDINONE, 4-HYDROXY-, (S)
  • 2-PYRROLIDINONE, 4-HYDROXY-, (4S)-
  • (4S)-4-HYDROXYPYRROLIDIN-2-ONE
  • 4-HYDROXY-PYRROLIDIN-2-ONE
  • (s)-(-)-β-hydroxy-γ-butyrolactam
  • (s)-β-hydroxy-γ-butyrolactam
  • (S)-(-)-4-HYDROXY-2-PYRROLIDINONE
  • (S)-(+)-4-HYDROXY-2-PYRROLIDINONE
  • (S)-4-HYDROXY-2-PYRROLIDINONE
  • (S)-4-HYDROXY-2-PYRROLIDONE
  • (S)-4-HYDROXY-PYRROLIDINE-2-ONE
  • SHPD
  • (S)-BETA-HYDROXY-GAMMA-BUTYROLACTAM
  • (S)-(-)-4-Hydroxy-2-pyrrolinone
  • (4S)-4-hydroxy-2-pyrrolidone
  • (S)-4-Hydroxy-pyrrolidin-2-one
  • (4S)-(-)-4-Hydroxy-2-oxopyrrolidine, (4S)-(-)-beta-Hydroxy-gamma-butyrolactam
  • (4S)-4-Hydroxy-2-pyrrolidinone
  • OxiracetaM iMpurity A
  • Oxiracetam Impurity 9
  • (S)-4-Mercapto-2-pyrrolidone
  • Oxiracetam Impurity A ((S)-4-Hydroxy-2-pyrrolidinone)
  • (S)-(-)-4-Hydroxy-2-pyrrolidinone 97%
  • (S)-4-Hydroxy-2-pyrrolidone,99%e.e.
  • Oxiracetam impurity H
  • Oxiracetam Impurity N
  • (S)-(-)-4-Hydroxy-2-pyrrolidone&gt
  • Busulfan Impurity1706
  • Oxiracetam impurities1718
  • (S)-(-)-4-Hydroxy-2-pyrrolidinone (Oxiracetam Impurity)
  • 68108-18-9
  • C4H7NO2
  • Heterocyclic Building Blocks
  • Pyrrolidines
  • Chiral Building Blocks
  • Asymmetric Synthesis
  • Amines
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Chiral
  • Pyrrolidinone derivatives
  • Drug Intermediates